N-n-tetradecanoyl methyl (L)-alaninate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-n-tetradecanoyl methyl (L)-alaninate
• 英文别名: N-(tetradecanoyl)alanine methyl ester；methyl N-tetradecanoyl-L-alaninate；CH3(CH2)12CONHCH(CH3)COOMe；Methyl tetradecanoyl-l-alaninate；methyl (2S)-2-(tetradecanoylamino)propanoate
• 化学式: C₁₈H₃₅NO₃
• 分子量: 313.481
• InChiKey: PVEPOGRPSLDEPB-INIZCTEOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  22
• 可旋转键数：
  15
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  55.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-n-tetradecanoyl methyl (L)-alaninate 在 水 、 lithium hydroxide 作用下， 以 四氢呋喃 为溶剂， 反应 12.0h， 以100%的产率得到N-十四碳酰基-L-丙氨酸
  参考文献：
  名称：

  使用基于氧杂降冰片烷的非离子两亲物的药物递送载体的模块化方法。

  摘要：

  使用氨基酸单元作为亲水性和亲脂性结构域之间的间隔基来控制具有羟基化氧杂硼硼烷头部的非离子两亲物的自组装，以获得球形的超分子聚集体。评估了这些系统包含布洛芬等治疗剂的能力及其药物释放曲线。除了指导组装外，还发现中间的氨基酸单元也有助于药物的包封。胆固醇的存在改善了它们的载药能力，并且通过含有苯丙氨酸残基作为间隔物（NC1c）的制剂显示出高达66％的包封效率。在这种情况下，没有爆发释放，并且在24小时结束时观察到45％的药物释放（参见基于大豆磷脂酰胆碱的制剂＝ 49％）。SEM，Cryo-TEM，

  DOI：

  10.1039/c6tb02192a
• 作为产物：
  描述：

  肉豆蔻酸 在 草酰氯 、 potassium carbonate 、 N,N-二甲基甲酰胺 作用下， 以 二氯甲烷 、 水 为溶剂， 反应 4.08h， 生成 N-n-tetradecanoyl methyl (L)-alaninate
  参考文献：
  名称：

  来自耐受蔷薇的 N-酰化丙氨酸甲酯（名称），群体感应自诱导剂的结构类似物，N-酰基高丝氨酸内酯

  摘要：

  玫瑰杆菌进化枝是海洋中最重要的细菌群之一。研究了耐受 Roseovarius EL 164 的液体培养物以生产自诱导剂，例如 N-酰基高丝氨酸内酯 (AHL) 和其他次生代谢物。XAD 提取物通过 GC/MS 进行分析。鉴定了两种 AHL，Z7-C14：1-高丝氨酸内酯 (HSL) 和 C15：1-HSL。此外，提取物中含有 5 种化合物，其分子离子峰位于 m/z 104、145 和 158，因此其质谱图与 AHL 的质谱相似，相应峰位于 m/z 102、143 和 156。通过柱层析、核磁共振分析得到的化合物，用于确定 CC 键位置的二甲基二硫衍生化以及最终合成具有所提出结构的化合物证实该化合物为 (Z)-N-(十六进制-9-烯酰基)丙氨酸甲酯。另外四种次要化合物被确定为 C14:0-、C15:0-、C16:0- 和 C17:1-N-酰化丙氨酸甲酯（名称）。以前没有从自然资源中描述过所有名称。BLASTp

  DOI：

  10.1002/cbdv.201300210

文献信息

• A new aromatic amino acid based organogel for oil spill recovery
  作者：Shibaji Basak、Jayanta Nanda、Arindam Banerjee

  DOI：10.1039/c2jm30711a

  日期：——

  An aromatic amino acid (phenylglycine) based amphiphile with amide and ester groups and a long fatty acyl chain has been found to form organogels selectively in the fuel hydrocarbon solvents including hexane, heptane, cyclohexane, diesel, kerosene and pump-oil at room temperature. Organogels have been well characterized morphologically by field emission scanning electron microscopy (FE-SEM) and atomic force microscopy (AFM). Morphological studies of these xerogels have revealed the presence of fascinating right-handed twisted nanoribbons (in n-heptane and n-octane). Involvement of different non-covalent interactions among the gelator molecules within the gel matrix has been studied using FT-IR and XRD. The organogel in diesel is mechanically stable with high yield stress (177.8 Pa) and storage modulus (>104 Pa) values, as has been evidenced from the rheological studies. Interestingly, this gelator compound exhibits phase selective gelation properties and the phase selective gelation occurs efficiently and quickly (within 90 s), in oil–water mixtures and the gelator molecule can be recovered and reused several times easily, indicating its applicability in oil spill cleaning.

  研究发现，一种芳香族氨基酸（苯基甘氨酸）亲和剂具有酰胺基、酯基和长脂肪酰基链，可在室温下选择性地在燃料烃溶剂（包括己烷、庚烷、环己烷、柴油、煤油和泵油）中形成有机凝胶。场发射扫描电子显微镜（FE-SEM）和原子力显微镜（AFM）对有机凝胶的形态进行了很好的表征。对这些异凝胶的形态学研究表明，它们存在迷人的右旋扭曲纳米带（在正庚烷和正辛烷中）。利用傅立叶变换红外光谱（FT-IR）和 X 射线衍射（XRD）对凝胶基质中凝胶分子之间不同的非共价相互作用进行了研究。流变学研究证明，柴油中的有机凝胶具有较高的屈服应力（177.8 帕）和储存模量（>104 帕），机械性能稳定。有趣的是，这种凝胶剂化合物具有相选择凝胶化特性，在油水混合物中，相选择凝胶化发生得又快又好（90 秒内），而且凝胶剂分子可以很容易地多次回收和重复使用，这表明它适用于溢油清洁。
• NOVEL COMPOSITE BODY AND EMULSION COMPOSITION
  申请人：Kokyu Alcohol Kogyo Co., Ltd.

  公开号：EP3915642A1

  公开（公告）日：2021-12-01

  The purpose of the present invention is to provide a novel emulsion composition which is able to be used as an emulsifying agent. Another purpose of the present invention is to provide a novel composite body which is used for emulsification. An emulsion composition according to the present invention contains a carboxy group-containing polymer, an amide alcohol, and a polyglycerol fatty acid ester having one or more hydroxy groups. A composite body according to the present invention, which is used for O/W emulsification, is obtained by bonding a carboxy group-containing polymer, an amide alcohol, and a polyglycerol fatty acid ester having one or more hydroxy groups with each other.

  本发明的目的是提供一种可用作乳化剂的新型乳液组合物。本发明的另一个目的是提供一种用于乳化的新型复合体。根据本发明的乳液组合物含有含羧基的聚合物、酰胺醇和具有一个或多个羟基的聚甘油脂肪酸酯。通过将含羧基的聚合物、酰胺醇和具有一个或多个羟基的聚甘油脂肪酸酯相互粘合，可获得用于 O/W 型乳化的本发明复合体。
• Oxidative hair dying and conditioning composition and method for base breaking hair with an oxidative hair dye
  申请人：NUMBER THREE, INC.

  公开号：US10548824B2

  公开（公告）日：2020-02-04

  An oxidative hair dying and conditioning composition and method for base breaking hair with an oxidative hair dye composition provides a hair dying and conditioning composition that consists of a nonionic surfactant having a hydrophilic-lipophilic balance (HLB) of 12 or less, at least one liquid oil agent, at least one alcohol defined by a carbon chain of at least 14 carbon atoms, at least one anion surfactant, at least one amphoteric surfactant, and at least one solvent. Further, a base breaking method helps remove the hair border line by reducing the contrast between a hair's natural base color and highlights through application of a first agent consisting of an oxidative dye and alkaline agent, and a second agent consisting of an oxidative agent that are applied to the hair in two phases separated by a duration of about ten minutes, and rinsing/drying the hair between applications.

  一种氧化染发和护发组合物以及用氧化染发组合物打底的方法提供了一种染发和护发组合物，该组合物由亲水-亲油平衡（HLB）为 12 或更低的非离子表面活性剂、至少一种液体油剂、至少一种由至少 14 个碳原子的碳链定义的醇、至少一种阴离子表面活性剂、至少一种两性表面活性剂和至少一种溶剂组成。此外，基底破坏法通过减少头发天然基色与挑染颜色之间的对比度，帮助去除头发边界线，具体方法是在头发上涂抹由氧化染料和碱性剂组成的第一种药剂，以及由氧化剂组成的第二种药剂，这两种药剂分两个阶段涂抹在头发上，时间间隔约为十分钟，并在两次涂抹之间冲洗/烘干头发。
• Molecular mechanism of physical gelation of hydrocarbons by fatty acid amides of natural amino acids
  作者：Asish Pal、Yamuna K. Ghosh、Santanu Bhattacharya

  DOI：10.1016/j.tet.2007.05.028

  日期：2007.7

  A variety of fatty acid amides of different naturally occurring L-amino acids have been synthesized and they are found to form gels with various hydrocarbons. The gelation properties of these compounds were studied by a number of physical methods including FTIR spectroscopy, X-ray diffraction, scanning electron microscopy, differential scanning calorimetry, rheology, and it was found that gelation depended critically on the fatty acid chain length and the nature of the amino acid. Among them L-alanine based gelators were found to be the most efficient and versatile gelators as they self-assemble into a layered structure to form the gel network. Mechanisms for the assembly and formation of gels from these molecules are discussed. (c) 2007 Elsevier Ltd. All rights reserved.
• Oxidative Hair Dying and Conditioning Composition and Method for Base Breaking Hair with an Oxidative Hair Dye
  申请人：NUMBER THREE, INC.

  公开号：US20190307663A1

  公开（公告）日：2019-10-10

  An oxidative hair dying and conditioning composition and method for base breaking hair with an oxidative hair dye composition provides a hair dying and conditioning composition that consists of a nonionic surfactant having a hydrophilic-lipophilic balance (HLB) of 12 or less, at least one liquid oil agent, at least one alcohol defined by a carbon chain of at least 14 carbon atoms, at least one anion surfactant, at least one amphoteric surfactant, and at least one solvent. Further, a base breaking method helps remove the hair border line by reducing the contrast between a hair's natural base color and highlights through application of a first agent consisting of an oxidative dye and alkaline agent, and a second agent consisting of an oxidative agent that are applied to the hair in two phases separated by a duration of about ten minutes, and rinsing/drying the hair between applications.