2-hydroxyimino-heptanedioic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2-hydroxyimino-heptanedioic acid
• 英文别名: 2-Hydroxyimino-heptandisaeure；2-Hydroxyiminoheptanedioic acid；2-hydroxyiminoheptanedioic acid
• 化学式: C₇H₁₁NO₅
• 分子量: 189.168
• InChiKey: YDEWFECODYDBPI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  13
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  107
• 氢给体数：
  3
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2-hydroxyimino-heptanedioic acid 生成 己二酸
  参考文献：
  名称：

  Dieckmann, Chemische Berichte, 1900, vol. 33, p. 593

  摘要：

  DOI：
• 作为产物：
  描述：

  亚硝酸乙酯 、 2-环己酮甲酸乙酯 在 sodium ethanolate 作用下， 生成 2-hydroxyimino-heptanedioic acid
  参考文献：
  名称：

  Dieckmann, Chemische Berichte, 1900, vol. 33, p. 593

  摘要：

  DOI：

文献信息

• Management of Multiple Spontaneous Nasal Meningoencephaloceles
  作者：Rodney J. Schlosser、William E. Bolger

  DOI：10.1097/00005537-200206000-00008

  日期：2002.6

  AbstractObjectives/Hypothesis Multiple spontaneous nasal meningoencephaloceles in the same patient are rare lesions. Although many skull base defects occur after prior trauma or surgery, otolaryngologists must be aware of the potential for spontaneous encephaloceles. We present our experience with this unusual condition and discuss its pathophysiology and unique management issues.Study Design Retrospective.Methods Review of medical records, radiographic images, and cerebrospinal fluid pressures.Results We identified 5 patients with multiple, simultaneous, spontaneous encephaloceles: 4 patients with 2 encephaloceles and 1 patient with 3 encephaloceles (11 in all). Locations of the 11 encephaloceles were sphenoid lateral recess (6), frontal sinus with supraorbital ethmoid extension (2), ethmoid roof (1), frontal sinus (1), and central sphenoid (1). Three patients had bilateral sphenoid lateral recess encephaloceles, accounting for all six in that location. All four patients with available radiographic studies demonstrated empty sella turcica. Surgical approaches included endoscopic transpterygoid approach to the lateral sphenoid recess (3), endoscopic approach to ethmoid and central sphenoid (3), and osteoplastic flap with frontal sinus obliteration (2). We had 100% success at latest endoscopic follow‐up (mean period, 17 mo). Three patients had postoperative lumbar punctures with mean cerebrospinal fluid pressure of 28.3 cm water (range, 19–34 cm; normal range, 0–15 cm).Conclusions Multiple spontaneous encephaloceles can be managed safely and successfully using endoscopic and extracranial approaches. A high index of suspicion for this diagnosis must be maintained, especially in patients with radiographic evidence of laterally pneumatized sphenoid sinuses or empty sella. Spontaneous encephaloceles and cerebrospinal fluid leaks represent a form of intracranial hypertension.
• Dieckmann, Chemische Berichte, 1900, vol. 33, p. 593
  作者：Dieckmann

  DOI：——

  日期：——