Nickel-catalyzed coupling of R<sub>2</sub>P(O)Me (R = aryl or alkoxy) with (hetero)arylmethyl alcohols
作者:Wei-Ze Li、Zhong-Xia Wang
DOI:10.1039/d1ob00086a
日期:——
α-Alkylation of methyldiarylphosphine oxides with (hetero)arylmethyl alcohols was performed under nickel catalysis. Various arylmethyl and heteroarylmethyl alcohols can be used in this transformation. A series of methyldiarylphosphine oxides were alkylated with 30–90% yields. Functional groups on the aromatic rings of methyldiarylphosphine oxides or arylmethyl alcohols including OMe, NMe2, SMe, CF3, Cl, and
在镍催化下,甲基二芳基膦氧化物与(杂)芳基甲醇的α-烷基化反应。在该转化中可以使用各种芳基甲基和杂芳基甲基醇。一系列甲基二芳基膦氧化物被烷基化,收率30-90%。可以容许甲基二芳基氧化膦或芳基甲醇的芳环上的官能团包括OMe,NMe 2,SMe,CF 3,Cl和F基团。该条件也适合于二烷基甲基膦酸酯的α-烷基化反应。