二(L-赖氨酸)钙

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: 二(L-赖氨酸)钙
• 英文名称: calcium L-lysinate
• 英文别名: calcium;(2S)-2,6-diaminohexanoate
• 化学式: C₁₂H₂₆CaN₄O₄
• 分子量: 330.441
• InChiKey: IFJWCHSJEZRVMN-MDTVQASCSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  -4.0
• 重原子数：
  21
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  184
• 氢给体数：
  4
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  消退素E1 、 二(L-赖氨酸)钙 在 tocopherol 作用下， 以 甲醇 、 乙酸乙酯 为溶剂， 反应 0.33h， 以96%的产率得到bis((5S,6Z,8E,10E,12R,14Z,16E,18R)-5,12,18-trihydroxyicosa-6,8,10,14,16-pentaenoic acid) calcium L-lysinate
  参考文献：
  名称：

  [EN] COMPOSITIONS AND METHODS RELATING TO SALTS OF SPECIALIZED PRO-RESOLVING MEDIATORS OF INFLAMMATION
  [FR] COMPOSITIONS ET PROCÉDÉS RELATIFS À DES SELS DE MÉDIATEURS SPÉCIALISÉS DE PRO-RÉSOLUTION D'INFLAMMATION

  摘要：

  本发明涉及公式I-IV的化合物，它们是炎症特殊脂质介质的盐，包括含有它们的组合物，并且在治疗由慢性或过度炎症或两者都特征的各种疾病和障碍中使用它们的方法。

  公开号：

  WO2017210604A1
• 作为产物：
  描述：

  calcium bis(lysinate) monohydrate 在 乙腈 作用下， 以 甲醇 为溶剂， 反应 0.25h， 以to afford 3.26 g (97%) of subject material as a pale yellow powder的产率得到二(L-赖氨酸)钙
  参考文献：
  名称：

  Mineral Amino-Acid Complexes of Fatty Acids

  摘要：

  本发明涉及公式III的化合物，包括氨基酸组分、二价金属组分和反离子组分，以及含有该化合物的组合物和使用方法。

  公开号：

  US20150366980A1

文献信息

• Mineral Amino-Acid Complexes of Active Agents
  申请人：Thetis Pharmaceuticals LLC

  公开号：US20160199385A1

  公开（公告）日：2016-07-14

  The present invention provides compounds of Formula I and related compositions and methods.

  本发明提供了I式化合物及相关组合物和方法。
• Mineral amino-acid complexes of fatty acids
  申请人：Thetis Pharmaceuticals LLC

  公开号：US09242008B2

  公开（公告）日：2016-01-26

  The present invention relates to compound of Formula III comprising an amino acid component, a divalent metal component, and a counter-ion component, compositions containing same, and methods of use.

  本发明涉及一种公式III的化合物，其包括氨基酸组分、二价金属组分和对离子组分，以及含有该化合物的组合物和使用方法。
• Oxyalkylated quaternary ammonium compounds, processes for production thereof, and plant growth regulating compositions containing said compounds
  申请人：DAI-ICHI KOGYO SEIYAKU CO., LTD.

  公开号：EP0371406A1

  公开（公告）日：1990-06-06

  This invention relates to novel oxyalkylated quaternary ammonium compounds, processes for their production and plant growth regulating compositions containing the same compounds. Each of these oxyalkyl­ated quaternary ammonium compounds consists of an oxyalkylated quaternary ammonium cation and an anion selected from among carboxylic acid residues, amino­sulfonic acid residues and phosphoric acid ester residues. These oxyalkylated quaternary ammonium compounds are least phytotoxic, produce marked growth regulating effects on a broad species of plants and are not easily decomposed by microorganisms.

  本发明涉及新型氧烷化季铵化合物、其生产工艺以及含有相同化合物的植物生长调节组合物。每种氧烷基化季铵化合物都由氧烷基化季铵阳离子和选自羧酸残基、氨基磺酸残基和磷酸酯残基的阴离子组成。这些氧烷基化季铵化合物的植物毒性最小，可对多种植物产生明显的生长调节作用，而且不易被微生物分解。
• Method of making granulated L-lysine
  申请人：ARCHER DANIELS MIDLAND COMPANY

  公开号：EP0491638A2

  公开（公告）日：1992-06-24

  A dust free, free-flowing, L-LysineHCl granular product is made from a liquid solution or slurry by a spray granulation process. The L-LysineHCl is sprayed onto an agitated bed of L-LysineHCl seed particles until the size of the particles reach a harvest size. In one embodiment, the agitated bed is a fluidized bed. In other embodiments, the agitated bed is a rotating mechanical device including either a drying drum or a disk and cone combination, where the particles are grown in an intermittent spray/dry cycle. Then the harvested particles are sorted for size. Those particles which are a non-acceptable oversize are ground to seed size and returned to the agitated bed. Those particles which are a non-acceptable undersize are remelted, purified, and returned to the liquid solution. Other salts of L-Lysine may also be used, such as an L-Lysine sulfate salt, an L-Lysine phosphate salt, and an L-Lysine calcium salt.

  无尘、自由流动的 L-LysineHCl 颗粒产品是通过喷雾造粒工艺从液体溶液或浆液中制成的。将 L-LysineHCl 喷射到 L-LysineHCl 种子颗粒的搅拌床上，直到颗粒大小达到收获尺寸。在一个实施方案中，搅拌床是流化床。在其他实施方案中，搅拌床是一个旋转机械装置，包括干燥滚筒或圆盘和圆锥组合，颗粒在其中以间歇喷雾/干燥循环的方式生长。然后对收获的颗粒进行尺寸分类。不可接受的过大颗粒被研磨成种子大小，然后返回搅拌床。那些尺寸过小的颗粒会被重新熔化、提纯并返回到液体溶液中。也可使用 L-赖氨酸的其他盐类，如 L-赖氨酸硫酸盐、L-赖氨酸磷酸盐和 L-赖氨酸钙盐。
• Compositions and methods relating to salts of specialized pro-resolving mediators
  申请人：Thetis Pharmaceuticals LLC

  公开号：US10130719B2

  公开（公告）日：2018-11-20

  The present invention relates to compounds which are salts of specialized pro-resolving mediators (referred to herein as “SPMs”) which include lipoxins, resolvins, protectins, and their aspirin-triggered counterparts. The SPM salts described here contain at least one or two SPM molecules ionically bound to at least one basic function that is provided by a scaffold moiety as described herein, compositions containing same, and methods of using same in the treatment of various diseases and disorders characterized by chronic or excessive inflammation, or both.

  本发明涉及的化合物是特异性促溶解介质（本文称为 "SPMs"）的盐，其中包括脂质素、溶血素、保护素及其阿司匹林触发的对应物。本文所述的 SPM 盐含有至少一个或两个与本文所述的支架分子提供的至少一种基本功能离子结合的 SPM 分子、含有相同成分的组合物以及使用相同成分治疗以慢性或过度炎症为特征的各种疾病和失调或两者兼而有之的方法。