4-(4-chlorophenyl)-3,5-dimethyl-1,7-diphenyl-4,7-dihydro-1H-pyrazolo[4′,3′:5,6]pyrano[2,3-c]pyrazole

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-(4-chlorophenyl)-3,5-dimethyl-1,7-diphenyl-4,7-dihydro-1H-pyrazolo[4′,3′:5,6]pyrano[2,3-c]pyrazole
• 英文别名: 4-(4-chlorophenyl)-3,5-dimethyl-1,7-diphenyl-4,7-dihydro-1H-pyrano[2,3-c:6,5-c']dipyrazole；8-(4-Chlorophenyl)-6,10-dimethyl-4,12-diphenyl-2-oxa-4,5,11,12-tetrazatricyclo[7.3.0.03,7]dodeca-1(9),3(7),5,10-tetraene
• 化学式: C₂₇H₂₁ClN₄O
• 分子量: 452.943
• InChiKey: YKXJFWMAJXKRMX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.9
• 重原子数：
  33
• 可旋转键数：
  3
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  44.9
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4-氯苯甲醛 、 依达拉奉 在 Ag NPs decked graphene oxide composite 作用下， 以 水 为溶剂， 反应 1.5h， 以90%的产率得到4-(4-chlorophenyl)-3,5-dimethyl-1,7-diphenyl-4,7-dihydro-1H-pyrazolo[4′,3′:5,6]pyrano[2,3-c]pyrazole
  参考文献：
  名称：

  Ag NPs decked GO composite as a competent and reusable catalyst for ‘ON WATER’ chemoselective synthesis of pyrano[2,3-c:6,5-c′]dipyrazol]-2-ones

  摘要：

  We have synthesized and characterized Ag NPs decked GO composite and studied its role as reusable catalyst for the 'ON WATER' chemoselective synthesis of pyranodipyrazolones via the reaction of different carbonyl compounds with 3-methyl-1-phenyl-1H-pyrazol-5(4H)-one. This method illustrates significant selectivity for pyranodipyrazolones over arylmethylene bispyrazolols and arylmethylenepyrazolones. Synergistic effect of heterogenic nature of water with reactants and Ag NP5/G0 had profuse outcome on reaction as indicated by high TOF (18.03 x 10(-5) mol g(-1) min(-1)). Furthermore, catalyst was recycled for 7-times without significant loss of activity. (C) 2017 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2017.02.014

文献信息

• Four-Component Domino Strategy for the Combinatorial Synthesis of Novel 1,4-Dihydropyrano[2,3-<i>c</i>]pyrazol-6-amines
  作者：Selvaraj Kanchithalaivan、Sathiyamoorthi Sivakumar、Raju Ranjith Kumar、Palani Elumalai、Qazi Naveed Ahmed、Anil K. Padala

  DOI：10.1021/co4000997

  日期：2013.12.9

  An efficient one-pot four-component domino protocol for the combinatorial synthesis of novel 1,4-dihydropyrano[2,3-c]pyrazol-6-amines has been achieved. This transformation presumably occurs via cyclization- Knoevenagel condensation-Michael addition-tautomerism- intramolecular O-cyclization-elimination sequence of reactions. The significant features of this reaction include expedient one-pot process, short reaction time, no column chromatographic purification, excellent yield, and readily available starting materials.