tris(hydroxymethyl)methyl ammonium hydrogen malonate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: tris(hydroxymethyl)methyl ammonium hydrogen malonate
• 英文别名: 2-Amino-2-(hydroxymethyl)propane-1,3-diol;propanedioic acid；2-amino-2-(hydroxymethyl)propane-1,3-diol;propanedioic acid
• 化学式: C₃H₃O₄*C₄H₁₁NO₃*H
• 分子量: 225.199
• InChiKey: IYFXRWGCBCSKEP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.79
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  161
• 氢给体数：
  6
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  丙二酸 、 三羟甲基氨基甲烷 以 乙醇 为溶剂， 反应 2.0h， 以67%的产率得到tris(hydroxymethyl)methyl ammonium hydrogen malonate
  参考文献：
  名称：

  生物活性羧酸的三（羟甲基）甲基铵盐。合成、性质和晶体结构

  摘要：

  摘要 三（羟甲基）甲基铵盐，[C(CH2OH)3NH3]X，是通过三（羟甲基）氨基甲烷（TRIS）与羧酸（肉桂酸、苯甲酸、水杨酸、烟酸、2-甲基苯氧乙酸、琥珀酸、丙二酸、草酸、苹果酸和柠檬酸）。新化合物（1-15）通过1H NMR、13C NMR、FT-IR、元素分析和热分析方法进行了表征。三(羟甲基)甲基丙二酸氢铵、琥珀酸氢铵和2-甲基苯氧基乙酸铵的晶体结构由单晶X射线衍射确定。已经研究了一些合成的三（羟甲基）甲基铵盐对细菌大肠杆菌、金黄色葡萄球菌、结核分枝杆菌和真菌白色念珠菌和黑曲霉的抗菌活性。

  DOI：

  10.1016/j.molstruc.2020.127813

文献信息

• Improved methodology for colorimetrically determining the concentration of white blood cells in a biological fluid
  申请人：Bayer Corporation

  公开号：EP0713093A2

  公开（公告）日：1996-05-22

  A composition, method and test device for determining the presence of leukocytes, esterase or protease in a test sample are disclosed. The composition comprises an ester which is hydrolyzed in the presence of leukocyte, esterase or protease to form a reaction product which couples with a diazonium salt to produce a detectable color change. The composition further comprises the salt of an alkaline earth metal which stabilizes the composition during manufacture and prevents the occurrence of false or background color change due to reactivity of the diazonium salt in the absence of leukocyte, esterase or protease.

  本发明公开了一种用于确定测试样品中是否存在白细胞、酯酶或蛋白酶的组合物、方法和测试装置。该组合物包含一种酯，它在白细胞、酯酶或蛋白酶的存在下水解形成反应产物，该反应产物与重氮盐偶联产生可检测的颜色变化。该组合物还包括碱土金属盐，可在生产过程中稳定组合物，并防止在没有白细胞、酯酶或蛋白酶的情况下，由于重氮盐的反应性而发生错误的或背景的颜色变化。
• Compositions and methods for ameliorating CNS inflammation, psychosis, delirium, PTSD or PTSS
  申请人：THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

  公开号：US10407374B2

  公开（公告）日：2019-09-10

  The invention provides compositions and methods for ameliorating, treating, reversing or preventing pathology or inflammation in the central nervous system (CNS), or the brain, caused or mediated by NFkB, IL-6, IL-6-R, NADPH oxidase (Nox), and/or superoxide and/or hydrogen peroxide production by a NADPH oxidase, including for example ameliorating, treating, reversing or preventing schizophrenia, psychosis, delirium, e.g., post-operative delirium, drug-induced psychosis, psychotic features associated with frailty syndrome (FS), aging, depression, dementias; traumatic war neurosis, post traumatic stress disorder (PTSD) or post-traumatic stress syndrome (PTSS), Amyotrophic Lateral Sclerosis (ALS, or Lou Gehrig's Disease), and/or Multiple Sclerosis (MS). The invention also provides methods for purifying a C60 fullerene, C3 (tris malonic acid C60) or malonic acid derivatives.

  本发明提供了用于改善、治疗、逆转或预防由 NFkB、IL-6、IL-6-R、NADPH 氧化酶（Nox）和/或 NADPH 氧化酶产生的超氧化物和/或过氧化氢引起或介导的中枢神经系统（CNS）或大脑中的病理或炎症的组合物和方法，包括例如改善、治疗、逆转或预防精神分裂症、精神病、谵妄，例如术后谵妄、药物诱发的精神病、与虚弱综合征（FS）相关的精神病特征、衰老、抑郁、痴呆症；创伤性战争神经症、创伤后应激障碍、创伤性战争神经症、创伤后应激障碍（PTSD）或创伤后应激综合征（PTSS）、肌萎缩侧索硬化症（ALS，或卢伽雷氏症）和/或多发性硬化症（MS）。本发明还提供了纯化 C60 富勒烯、C3（三丙二酸 C60）或丙二酸衍生物的方法。
• Carboxyfullerenes and methods of use thereof
  申请人：——

  公开号：US20030162837A1

  公开（公告）日：2003-08-28

  The instant invention is a method for increasing a metazoan's lifespan, comprising administering a carboxylated derivative of a C 60 fullerene. The instant invention further is a process for extending a metazoan's lifespan by administering a superoxide dismutase-mimetic as well as a composition comprising a superoxide dismutase-mimetic. Further, the instant invention comprises a pharmaceutical composition comprising carboxyfullerenes having x pairs of adjacent carbon atoms bonded to two carbons of the C 60 sphere wherein said adjacent carbon atom is further bonded to two groups of the general formula —COOH and —R, wherein R is independently selected from the group consisting of —COOH and —H, and wherein x is at least 1. A further embodiment is a non-metal containing composition which can catalytically eliminate two biologically reactive species. Another embodiment is a method of enhancing elimination of reactive oxygen species in eukaryotic cells by contacting cells with a superoxide dismutase mimetic.

  本发明是一种延长变态类动物寿命的方法，包括给变态类动物服用一种 C 60 富勒烯的羧化衍生物。本发明进一步是一种通过施用超氧化物歧化酶模拟物以及包含超氧化物歧化酶模拟物的组合物来延长元胞动物寿命的方法。此外，本发明还包括一种药物组合物，该组合物包含羧基富勒烯，其 x 对相邻碳原子与 C 60 球的两个碳原子键合，其中所述相邻碳原子进一步与通式为-COOH 和-R 的两个基团键合，其中 R 独立选自由-COOH 和-H 组成的组，且 x 至少为 1。 另一个实施方案是一种含非金属的组合物，它可以催化消除两种生物活性物种。 另一个实施方案是一种通过使细胞与超氧化物歧化酶模拟物接触来增强消除真核细胞中活性氧的方法。
• Therapeutic malonic acid/acetic acid C60 tri-adducts of buckminsterfullerene and methods related thereto
  申请人：——

  公开号：US20040034100A1

  公开（公告）日：2004-02-19

  Disclosed and claimed herein are e,e,e malonic acid/acetic acid tri-adduct of buckminsterfullerene of the general formula C 60 R 3 , wherein each R is independently selected from groups of the formula —CR 1 R 2 wherein each R 1 and R 2 is independently selected from the group consisting of —H and —COOH, provided, however, that at least one of the R 1 's and R 2 's is a hydrogen. Processes for preparing and uses of the same for treating neuronal injury and for life-extension are also disclosed and claimed herein.

  本文所公开和权利要求的是通式为C 60 R 3 其中每个 R 独立地选自式 -CR 1 R 2 其中每个 R 1 和 R 2 独立选自-H 和-COOH 所组成的组，但其中至少一个 R 1 和 R 2 是氢。本文还公开了用于治疗神经元损伤和延长寿命的制备方法和用途。
• Methods and compositions useful to prevent in-grown hair arising from shaving
  申请人：Faryniarz Raymond Joseph

  公开号：US20050202054A1

  公开（公告）日：2005-09-15

  A method and composition is provided for managing in-grown hair which involves applying to those areas malonic acid or a salt thereof in a carrier. The method and composition allows for comfortable shaving of skin by minimizing the problem of in-grown hair.

  本发明提供了一种用于控制毛发生长的方法和组合物，包括在这些部位涂抹丙二酸或其在载体中的盐。这种方法和组合物可以最大限度地减少毛发内生的问题，从而使皮肤剃须时感觉舒适。