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二十八烷醇 | 22725-64-0

中文名称
二十八烷醇
中文别名
——
英文名称
octacosanal
英文别名
1-octacosanal
二十八烷醇化学式
CAS
22725-64-0
化学式
C28H56O
mdl
——
分子量
408.752
InChiKey
LVXORIXZNUNHGQ-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

物化性质

  • 沸点:
    410.1±8.0 °C(Predicted)
  • 密度:
    0.837±0.06 g/cm3(Predicted)
  • LogP:
    13.659 (est)
  • 保留指数:
    3014

计算性质

  • 辛醇/水分配系数(LogP):
    13.6
  • 重原子数:
    29
  • 可旋转键数:
    26
  • 环数:
    0.0
  • sp3杂化的碳原子比例:
    0.96
  • 拓扑面积:
    17.1
  • 氢给体数:
    0
  • 氢受体数:
    1

SDS

SDS:5ed764be989f79787de7622d286849f0
查看

反应信息

  • 作为反应物:
    描述:
    二十八烷醇甲醇 生成 1,1-dimethoxyoctacosane
    参考文献:
    名称:
    SIMO, R.;GRIMALT, J. O.;COLOM-ALTES, M.;ALBAIGES, J., FRESENIUS J. ANAL. CHEM., 339,(1991) N0, C. 757-764
    摘要:
    DOI:
  • 作为产物:
    描述:
    二十八烷醇calcium carbonatepyridinium chlorochromate 作用下, 以 二氯甲烷正己烷 为溶剂, 反应 2.75h, 以45.9%的产率得到二十八烷醇
    参考文献:
    名称:
    EP1634588
    摘要:
    公开号:
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文献信息

  • Methylene Blue Derivatives
    申请人:Rariy V. Roman
    公开号:US20070116757A1
    公开(公告)日:2007-05-24
    Pharmaceutical compositions comprising a fatty acid salt, a dicarboxylic acid salt, an alkyl sulfate salt, an aryl sulfate salt or an alkyl aryl sulfonate salt of methylene blue or a derivative of methylene blue are described herein. The compositions are preferably administered orally and can be administered as tablets, soft or hard shell capsules (e.g. soft gelatin capsules), suspensions or solutions. The composition can also be formulated as a suppository or enema or rectal administration. The compositions further comprise a pharmaceutically acceptable carrier and optionally one or more pharmaceutically acceptable excipients. Suitable excipients include diluents, binders, plasticizers, lubricants, disintegrants, colorants, stabilizers, surfactants, and combinations thereof. The fatty acid salts, alkyl sulate salts, aryl sulfate salts or alkyl aryl sulfonate salts can be co-mixed or co-melted with one or more fatty acids to make more hydrophobic compositions, which may result in less staining formulations. The compositions can be formulated for immediate release, controlled release such as extended release, delayed release, and pulsatile release, or combinations thereof. In one embodiment, the derivative of methylene blue is methylene dodecylsulfate.
    本文描述了包含脂肪酸盐、二羧酸盐、烷基硫酸盐、芳基硫酸盐或烷基芳基磺酸盐的甲蓝或甲蓝衍生物的制药组合物。这些组合物最好是口服给药,可以制成片剂、软壳或硬壳胶囊(例如软明胶胶囊)、悬浮液或溶液进行给药。该组合物也可以制成栓剂或灌肠剂或直肠给药。这些组合物还包括一种药用可接受载体,以及可选地一种或多种药用可接受的辅料。适用的辅料包括稀释剂、粘结剂、增塑剂、润滑剂、崩解剂、色素、稳定剂、表面活性剂以及它们的组合。脂肪酸盐、烷基硫酸盐、芳基硫酸盐或烷基芳基磺酸盐可以与一种或多种脂肪酸共混或共熔,制成更疏水的组合物,这可能导致更少的染色配方。这些组合物可以制成即时释放、控制释放(如延长释放)、延迟释放和脉冲释放,或者以上述的组合形式。在一个实施例中,甲蓝的衍生物是十二烷基硫酸甲蓝。
  • Trifluorothymidine derivatives, process for producing the same and anti-cancer agent containing the same
    申请人:MITSUI TOATSU CHEMICALS, Inc.
    公开号:EP0517262A1
    公开(公告)日:1992-12-09
    Novel trifluorothymidine derivatives having anti-cancer activities are disclosed. The trifluorothymidine derivatives of the present invention are represented by the formula [I]: (wherein R¹ represents hydrogen atom or C₁ - C₄ alkyl group; R² represents hydrogen atom, C₁ - C₃₀ saturated or unsaturated alkyl-substituted carbonyl group, alkyl-substituted benzoyl group, C₁ - C₄ alkyloxycarbonyl group; dimethylaminoethyloxycarbonyl group, C₁ - C₄ alkyloxymethyl group, butoxyethoxyacetyl group, benzyl group, C₁ - C₂₀ alkyl-substituted silyl group, silyl group substituted with C₁ - C₁₀ alkyl group and/or phenyl group, C₁ - C₃₀ cyclic or chain alkyl-substituted carbamoyl group, diethylaminopropylcarbamoyl group, N-alkylpiperazinylacetyl group, N-alkylprolyl group, valyl group, trityl group, alkyl-substituted phosphoryl group or propargyl group; R³ represents hydrogen atom, C₁ - C₄ alkyl group, benzyl group, benzoyl group, C₁ - C₄ alkyloxy-substituted benzoyl group, furoyl group, C₁ - C₄ alkyloxymethyl group or C₁ - C₄ alkyl-substituted carbonyl group).
    本发明揭示了具有抗癌活性的新型三氟胸腺嘧啶衍生物。本发明的三氟胸腺嘧啶衍生物由式[I]表示:(其中R¹表示氢原子或C₁-C₄烷基;R²表示氢原子,C₁-C₃₀饱和或不饱和烷基取代的羰基基团,取代苯甲酰基团,C₁-C₄烷氧羰基基团;二甲氨基乙氧羰基基团,C₁-C₄烷氧甲基基团,丁氧乙氧乙酰基基团,苯甲基团,C₁-C₂₀烷基取代的硅基团,取代C₁-C₁₀烷基和/或苯基的硅基团,C₁-C₃₀环状或链状烷基取代的氨基甲酰基团,二乙氨基丙基氨基甲酰基团,N-烷基哌嗪基乙酰基团,N-烷基丙氧基基团,瓦林基团,三苯甲基基团,取代磷酸基团或丙炔基团的烷基;R³表示氢原子,C₁-C₄烷基,苯甲基,苯甲酰基,C₁-C₄烷氧取代的苯甲酰基团,呋喃基,C₁-C₄烷氧甲基基团或C₁-C₄烷基取代的羰基基团)。
  • Composition containing higher fatty acid derivative and foods and drinks
    申请人:Chinen Isao
    公开号:US20060127450A1
    公开(公告)日:2006-06-15
    An object of the invention is to provide a composition containing a higher fatty acid derivative, which can be easily produced at low cost, is effective as an agent for prevention and treatment of osteoporosis induced by various factors such as diet, dietary restriction, etc., is highly safe, and can be used regularly; and foods and drinks comprising the composition, which is effective as an agent for prevention and treatment of osteoporosis induced by various factors such as diet, dietary restriction, etc., and suitable as foods and drinks for hospitals, healthy drinks or foods, feeds, etc. The composition containing a higher fatty acid derivative comprises one kind of higher fatty acid derivatives as an active ingredient and is used as an agent for prevention and treatment of osteoporosis. The higher fatty acid derivatives include octacosanal. The foods and drinks comprise the composition with a higher fatty acid derivative.
    本发明的目的是提供一种含有高级脂肪酸衍生物的组合物,该组合物可以以低成本轻松生产,对于由饮食、饮食限制等各种因素引起的骨质疏松症具有预防和治疗作用,具有高度安全性,并可定期使用;以及包含该组合物的食品和饮料,该组合物对于由饮食、饮食限制等各种因素引起的骨质疏松症具有预防和治疗作用,适合作为医院、健康饮料或食品、饲料等的食品和饮料。含有高级脂肪酸衍生物的组合物包括一种高级脂肪酸衍生物作为活性成分,并用作预防和治疗骨质疏松症的药剂。高级脂肪酸衍生物包括辛二十醇。食品和饮料包括含有高级脂肪酸衍生物的组合物。
  • Screening method
    申请人:Mori Masaaki
    公开号:US20050154190A1
    公开(公告)日:2005-07-14
    The present invention relates to a screening method/screening kit for screening a compound or its salt that changes the binding properties of (a) a protein containing the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1 or SEQ ID NO: 19, its partial peptides, or salts thereof, and (b) a ligand capable of binding specifically to the protein; compounds obtained by the screening or salts thereof; pharmaceuticals comprising the compounds or salts thereof; a protein containing the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 19; etc. The compounds obtained by the screening of the present invention are useful as agents for the prevention/treatment of, for example, neurodegenerative diseases, immunological diseases, edema, acid indigestion, etc.
    本发明涉及一种筛选方法/筛选试剂盒,用于筛选改变(a)与SEQ ID NO:1或SEQ ID NO:19所代表的氨基酸序列相同或基本相同的蛋白质、其部分肽段或其盐的结合性质,以及(b)能够特异性结合于蛋白质的配体的化合物或其盐。本发明筛选得到的化合物或其盐;包含该化合物或其盐的药物;与SEQ ID NO:19所代表的氨基酸序列相同或基本相同的蛋白质等均属于本发明的范畴。本发明所筛选得到的化合物可用作预防/治疗神经退行性疾病、免疫性疾病、水肿、酸性消化不良等的药剂。
  • POLYBUTYLENE TEREPHTHALATE RESIN COMPOSITION AND PELLET THEREOF
    申请人:Doi Kumiko
    公开号:US20130309500A1
    公开(公告)日:2013-11-21
    Provided are a polybutylene terephthalate resin composition which is excellent in mold releasability and which can suppress deterioration in molding stability and aggregation of the polybutylene terephthalate resin composition due to blooming of a mold release agent; and a pellet thereof. The polybutylene terephthalate resin composition contains 0.01 to 5.0 parts by mass of (B) a saturated fatty acid ester of a polyglycerol represented by formula (I) described below with respect to 100 parts by mass of (A) a polybutylene terephthalate resin. In formula (I), R 1 s each may be the same or different and are C 19-30 saturated aliphatic acyl groups, and n is an integer from 1 to 10.
    提供了一种聚丁烯对苯二甲酸酯树脂组合物,其具有出模性能优异且可以抑制模具释放剂开花引起的聚丁烯对苯二甲酸酯树脂组合物的成型稳定性恶化和聚集,以及其颗粒。聚丁烯对苯二甲酸酯树脂组合物包含(A)聚丁烯对苯二甲酸酯树脂100质量份中的0.01至5.0质量份的(B)多甘醇的饱和脂肪酸酯,其由以下式(I)表示。在式(I)中,R1s各自可以相同或不同,是C19-30饱和脂肪族酰基,n是1至10的整数。
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