(E)-2-(3-hydroxy-4-methoxybenzylidene)-5,6,7-trimethoxy-2,3-dihydro-1H-inden-1-one

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 英文名称: (E)-2-(3-hydroxy-4-methoxybenzylidene)-5,6,7-trimethoxy-2,3-dihydro-1H-inden-1-one
• 英文别名: (2E)-2-[(3-hydroxy-4-methoxyphenyl)methylidene]-5,6,7-trimethoxy-3H-inden-1-one
• 化学式: C₂₀H₂₀O₆
• 分子量: 356.375
• InChiKey: QUWJNNKQTVKZER-NTUHNPAUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  74.2
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  3-(3,4,5-三甲氧基苯基)丙酸 在 磷酸酐 、 sodium hydroxide 作用下， 以 甲烷磺酸 、 乙醇 为溶剂， 反应 13.0h， 生成 (E)-2-(3-hydroxy-4-methoxybenzylidene)-5,6,7-trimethoxy-2,3-dihydro-1H-inden-1-one
  参考文献：
  名称：

  Synthesis, biological evaluation and mechanism study of a class of benzylideneindanone derivatives as novel anticancer agents

  摘要：

  我们的发现揭示了苄亚甲基吲哚酮基团作为一种新的吸引人的骨架，用于有针对性地发现有丝分裂靶向药物。

  DOI：

  10.1039/c5md00139k

文献信息

• [EN] COMPOUNDS FOR TREATMENT OF ANGIOGENESIS-MEDIATED DISEASES<br/>[FR] COMPOSÉS POUR TRAITER DES MALADIES MÉDIÉES PAR L'ANGIOGENÈSE
  申请人：UNIV INDIANA RES & TECH CORP

  公开号：WO2014182695A1

  公开（公告）日：2014-11-13

  Synthetic cremastranone and cremastranone analogs are disclosed. Additionally, methods for synthesizing cremastranone and cremastranone analogs are disclosed. Methods of treating ocular neovascularization disorders and treating angiogenesis-mediated disease are also disclosed.

  披露了合成克雷马斯特罗内和克雷马斯特罗内类似物。此外，还披露了合成克雷马斯特罗内和克雷马斯特罗内类似物的方法。还披露了治疗眼部新生血管疾病和治疗血管生成介导的疾病的方法。
• COMPOUNDS FOR TREATMENT OF ANGIOGENESIS-MEDIATED DISEASES
  申请人：INDIANA UNIVERSITY RESEARCH & TECHNOLOGY CORPORATION

  公开号：US20160060241A1

  公开（公告）日：2016-03-03

  Synthetic cremastranone and cremastranone analogs are disclosed. Additionally, methods for synthesizing cremastranone and cremastranone analogs are disclosed. Methods of treating ocular neovascularization disorders and treating angiogenesis-mediated disease are also disclosed.

  本文介绍了合成人造的cremastranone和类似物的方法。此外，还介绍了合成cremastranone和cremastranone类似物的方法。还介绍了治疗眼部新生血管疾病和治疗血管生成介导的疾病的方法。
• Compounds for treatment of angiogenesis-mediated diseases
  申请人：Indiana University Research and Technology Corporation

  公开号：US10238627B2

  公开（公告）日：2019-03-26

  Synthetic cremastranone and cremastranone analogs are disclosed. Additionally, methods for synthesizing cremastranone and cremastranone analogs are disclosed. Methods of treating ocular neovascularization disorders and treating angiogenesis-mediated disease are also disclosed.

  本发明公开了合成的 cremastranone 和 cremastranone 类似物。此外，还公开了合成 cremastranone 和 cremastranone 类似物的方法。还公开了治疗眼部新生血管疾病和治疗血管生成介导疾病的方法。
• COMPOSITION FOR BLOCKING ANGIOGENESIS
  申请人：Indiana University Research and Technology Corporation

  公开号：US20210228538A1

  公开（公告）日：2021-07-29

  Compositions including the combination of cremastranone analogs and anti-angiogenic agents and the use of the compositions for targeting ocular angiogenesis such as seen in neovascular eye diseases are disclosed.
• [EN] COMPOSITION FOR BLOCKING ANGIOGENESIS<br/>[FR] COMPOSITION DE BLOCAGE DE L'ANGIOGENÈSE
  申请人：UNIV INDIANA RES & TECH CORP

  公开号：WO2017091473A1

  公开（公告）日：2017-06-01

  Compositions including the combination of cremastranone analogs and anti-angiogenic agents and the use of the compositions for targeting ocular angiogenesis such as seen in neovascular eye diseases are disclosed.