Bis(6-bromo-2-pyridyl)methoxy<4-((tert-butyldimethylsilyl)oxy)phenyl>methane

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Bis(6-bromo-2-pyridyl)methoxy<4-((tert-butyldimethylsilyl)oxy)phenyl>methane
• 英文别名: Bis(6-bromo-2-pyridyl)methoxy{4-[(tert-butyldimethylsilyl)oxy]phenyl}methane；[4-[Bis(6-bromopyridin-2-yl)-methoxymethyl]phenoxy]-tert-butyl-dimethylsilane
• 化学式: C₂₄H₂₈Br₂N₂O₂Si
• 分子量: 564.392
• InChiKey: JUFJDDJKUKWMQK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.32
• 重原子数：
  31
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  44.2
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  三甲基乙腈 、 Bis(6-bromo-2-pyridyl)methoxy<4-((tert-butyldimethylsilyl)oxy)phenyl>methane 在 正丁基锂 作用下， 以 乙醚 、 正己烷 为溶剂， 以83%的产率得到Bis<6-(1-oxo-2,2-dimethylpropyl)-2-pyridyl>methoxy<4-((tert-butyldimethylsilyl)oxo)phenyl>methane
  参考文献：
  名称：

  Preparation of Dipyridylmethane Ligands with Pseudo-C2 Symmetry. Grafting on Polystyrenes via Transformation to Phenolic Derivatives

  摘要：

  Efficient grafting of dipyridylmethane ligands on highly cross-linked as well as gel-type chloromethylated polystyrenes has been achieved using phenolic derivatives of the ligands. In this way, chiral polymer-supported ligands with pseudo-C-2 symmetry were obtained. The synthesis of the ligands and their grafting under mild conditions are described, as well as the preparation of monomeric models. During reduction of 6,6'-(2,2-dimethyl-1-oxopropyl) derivatives with sodium borohydride, the R,S isomers were unexpectedly formed with high selectivity.

  DOI：

  10.1021/jo00111a038
• 作为产物：
  描述：

  Bis(6-bromo-2-pyridyl)<4-((tert-butyldimethylsilyl)oxy)phenyl>methanol 、 碘甲烷 在 sodium hydride 作用下， 以 四氢呋喃 为溶剂， 以83%的产率得到Bis(6-bromo-2-pyridyl)methoxy<4-((tert-butyldimethylsilyl)oxy)phenyl>methane
  参考文献：
  名称：

  Preparation of Dipyridylmethane Ligands with Pseudo-C2 Symmetry. Grafting on Polystyrenes via Transformation to Phenolic Derivatives

  摘要：

  Efficient grafting of dipyridylmethane ligands on highly cross-linked as well as gel-type chloromethylated polystyrenes has been achieved using phenolic derivatives of the ligands. In this way, chiral polymer-supported ligands with pseudo-C-2 symmetry were obtained. The synthesis of the ligands and their grafting under mild conditions are described, as well as the preparation of monomeric models. During reduction of 6,6'-(2,2-dimethyl-1-oxopropyl) derivatives with sodium borohydride, the R,S isomers were unexpectedly formed with high selectivity.

  DOI：

  10.1021/jo00111a038

文献信息

• Preparation of Dipyridylmethane Ligands with Pseudo-C2 Symmetry. Grafting on Polystyrenes via Transformation to Phenolic Derivatives
  作者：Vincent Levacher、Christina Moberg

  DOI：10.1021/jo00111a038

  日期：1995.3

  Efficient grafting of dipyridylmethane ligands on highly cross-linked as well as gel-type chloromethylated polystyrenes has been achieved using phenolic derivatives of the ligands. In this way, chiral polymer-supported ligands with pseudo-C-2 symmetry were obtained. The synthesis of the ligands and their grafting under mild conditions are described, as well as the preparation of monomeric models. During reduction of 6,6'-(2,2-dimethyl-1-oxopropyl) derivatives with sodium borohydride, the R,S isomers were unexpectedly formed with high selectivity.