二月桂基马来酸酯 | 2915-52-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 二月桂基马来酸酯
• 英文名称: di-dodecyl maleate
• 英文别名: dilauryl maleate；didodecyl (Z)-but-2-enedioate
• CAS: 2915-52-8
• 化学式: C₂₈H₅₂O₄
• 分子量: 452.718
• InChiKey: HEJZJSIRBLOWPD-VHXPQNKSSA-N

物化性质

• 物理描述：
  Liquid

计算性质

• 辛醇/水分配系数(LogP)：
  11.4
• 重原子数：
  32
• 可旋转键数：
  26
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

安全信息

• 危险类别码：
  R36/37/38
• 海关编码：
  2917190090
• 安全说明：
  S26,S36/37/39

反应信息

• 作为反应物：
  描述：

  二月桂基马来酸酯 在 sodium hydrogensulfite 作用下， 以 水 为溶剂， 以36%的产率得到1,4-双十二烷基磺酸基琥珀酸酯钠盐
  参考文献：
  名称：

  在水溶液中由氨基甲基（羟基）芳烃前体生成甲基醌

  摘要：

  从有机合成和生物学的观点来看，邻醌甲基化物（QMs）是重要的反应性中间体。已经研究了作为QM前体的N，N-二烷基-9-氨基甲基-10-菲咯啉及其萘类似物的光化学和热转化。这些前体容易与烷基乙烯基醚反应，分别得到2-烷氧基二苯并[ f，h ]苯并二氢吡喃酮和2-烷氧基苯并[ f ]苯并二氢吡喃。通过在反应溶剂中存在水分子并通过形成阴离子胶束和囊泡来加速QM的热和光化学生成。

  DOI：

  10.1016/j.tet.2005.04.037
• 作为产物：
  描述：

  马来酸酐 、 十二烷醇 在 硫酸 作用下， 以 甲苯 为溶剂， 反应 4.0h， 以80%的产率得到二月桂基马来酸酯
  参考文献：
  名称：

  二羧酸酯作为透皮渗透促进剂：链数和几何异构体的影响

  摘要：

  研究了基于二羧酸酯的一系列透皮渗透促进剂。单链两亲物明显比双链两亲物更有效。马来酸单十二烷基酯（一种顺式衍生物）比其反式异构体是一种更有效的增强剂，而琥珀酸酯的活性在很大程度上取决于供体媒介物。在非对映异构的酒石酸和内消旋酒石酸衍生物之间没有发现差异。

  DOI：

  10.1016/j.bmcl.2008.11.083

文献信息

• A comparative study of the thermal properties of homologous series of crystallisable n-alkyl maleate and itaconate monoesters
  作者：Jean-Victor Richard、Christelle Delaite、Gérard Riess、Anne-Sophie Schuller

  DOI：10.1016/j.tca.2015.10.015

  日期：2016.1

  Abstract Homologous series of crystallisable C8-C22 even-numbered alkane oligomers with either maleate or itaconate monoesters end-groups were synthesized. Their total phase change enthalpy (ΔHtpce) and entropy (ΔStpce) on melting, determined by DSC, show a linear dependence with the number of carbons of the alkyl chain. A comparison was performed with corresponding succinate derivatives. The influence

  摘要 合成了具有马来酸酯或衣康酸酯端基的可结晶C8-C​​22偶数烷烃低聚物的同源系列。它们的总相变焓 (ΔHtpce) 和熔化时的熵 (ΔStpce)，由 DSC 测定，显示出与烷基链碳数的线性相关性。与相应的琥珀酸酯衍生物进行了比较。鉴于通过组可加性方法估计的 ΔStpce 值，检查了端函数对 ΔStpce 的影响。可以证明实验和估计熵值之间的公平一致性。热重分析 (TGA) 表明，马来酸酯低聚物不如相应的琥珀酸酯和衣康酸酯衍生物稳定。这种行为可以通过降解过程的活化能来证实。
• Detection of Long Alkyl Esters of Succinic and Maleic Acid Using TLC-MALDI-MS
  作者：Hin-Hee Kim、Sang-Pil Han、Jeong-Kwon Kim、Yeong-Joon Kim

  DOI：10.5012/bkcs.2011.32.3.915

  日期：2011.3.20

  Four esters of succinic and maleic acid were synthesized, separated by thin-layer chromatography (TLC), and identified using matrix-assisted laser desorption/ionization-mass spectrometry (MALDI-MS). A comparison of matrix materials showed that 2,6-dihydroxybenzoic acid (2,6-DHB) yielded a greater ionization efficiency than 2,5-DHB prior to TLC separation. The location of each ester sample on the TLC plate was estimated by comparing the developed plate with a duplicate plate that had been visualized by immersion in a $KMnO_4$ solution. Generally, mass spectra obtained from the $KMnO_4$-visualized plate were relatively poor. Reproducible mass spectra with high peak abundance were difficult to obtain using the 2,6-DHB matrix from crude synthetic esters extracted from the TLC plates. Significant improvements in both reproducibility and sensitivity were realized by using pencil lead as the MALDI matrix. The current methodology will be beneficial to organic chemists since it can provide a guideline for simple and rapid characterization of small organic compounds.

  琥珀酸和马来酸的四种酯被合成、通过薄层色谱法（TLC）分离，并使用基质辅助激光解吸电离质谱法（MALDI-MS）进行鉴定。对基质材料的比较表明，在TLC分离之前，2,6-二羟基苯甲酸（2,6-DHB）的电离效率高于2,5-DHB。通过将展开的TLC板与浸入高锰酸钾溶液后可视化的复制板进行比较，估算了每个酯样品在TLC板上的位置。通常，从高锰酸钾可视化的板上获得的质谱相对较差。使用2,6-DHB基质从TLC板上提取的粗合成酯中难以获得具有高丰度峰的可重复质谱。通过使用铅笔芯作为MALDI基质，显著提高了重复性和灵敏度。当前方法将有利于有机化学家，因为它可以为简单快速地表征小有机化合物提供指导。
• Synthetic Bilayer Membranes with Anionic Head Groups
  作者：Toyoki Kunitake、Yoshio Okahata

  DOI：10.1246/bcsj.51.1877

  日期：1978.6

  Anionic amphiphiles which possess two normal alkyl groups as the hydrophobic residue and sulfonate, phosphate or carboxylate groups as the hydrophilic residue were prepared. Most of these compounds aggregate extensively in water to form vesicles and lamellae which are probably formed by the molecular bilayer. These aggregates are quite similar to the lecithin liposome with respect to the restricted molecular motion and cholesterol binding.

  具有两个普通烷基作为疏水残基以及磺酸盐、磷酸盐或羧酸盐作为亲水残基的阴离子两性分子已被制备出来。这些化合物大多在水溶液中广泛聚集形成囊泡和片层结构，这些结构很可能由分子双层形成。这些凝聚体与卵磷脂脂质体在分子运动受限和胆固醇结合方面非常相似。
• Porous polymer oil sorbents based on PET fibers with crosslinked copolymer coatings
  作者：Ayman M. Atta、Witold Brostow、Haley E. Hagg Lobland、Abdul-Raheim M. Hasan、Jose M. Perez

  DOI：10.1039/c3ra44759f

  日期：——

  terephthalate (NWPET) fibers modified by the adherence of crosslinked polymer coatings to the fiber surface. The NWPET fibers, which serve as a structural support for the applied functional coatings, were produced from recycled PET (polyethylene terephthalate) bottles. The oil absorbing coatings were comprised of crosslinked homopolymers and copolymers based on octadecyl acrylate (ODA), maleic anhydride (MA)

  油吸收剂（即溢出后可用于提取油的材料）是由非织造的聚对苯二甲酸乙二醇酯（NWPET）纤维制成的，该纤维经过交联的聚合物涂层在纤维表面的粘附而改性。NWPET纤维由回收的PET（聚对苯二甲酸乙二酯）瓶制成，可作为功能涂层的结构支撑。吸油涂料由基于丙烯酸十八烷基酯（ODA），马来酸酐（MA）和MA的相关酯的交联均聚物和共聚物组成。使用二乙烯基苯（DVB）作为交联剂，通过悬浮和本体聚合技术合成了交联的聚合物网络。通过在甲苯中和在甲苯中的10％原油中的吸油率测试，确定了涂覆的NWPET纤维作为吸油剂的功效。刚性，评估了交联聚合物的孔隙率和溶胀度，并将其与化学结构，组成和反应介质相关联。悬浮聚合产生所需的形态和功能，提供较高的孔隙率并因此具有高吸收能力。
• Personal care articles comprising hotmelt compositions
  申请人：——

  公开号：US20010018068A1

  公开（公告）日：2001-08-30

  The present invention relates to a substantially dry, disposable personal care article suitable for cleansing, said article comprising: a) a water insoluble substrate comprising a creped nonwoven layer; and b) a cleansing component disposed adjacent to said creped nonwoven layer, wherein said component comprises from about 10% to about 1000%, by weight of the water insoluble substrate, of a lathering surfactant and wherein the cleansing component exhibits a log [(&eegr; @ 25° C.)/(&eegr; @ 200° C.)] greater than about 0.45. Additionally, the present invention relates to a similar article that is characterized by a cleansing component that exhibits a complex viscosity measured under an oscillation stress of 1 Pa of greater than about 100 Pa·s. at 25° C. The present invention further relates to a substantially dry, disposable personal care article suitable for conditioning wherein the above-described article comprises a therapeutic benefit component, disposed adjacent to said water insoluble substrate, wherein said component comprises from about 10% to about 1000%, by weight of the water insoluble substrate, of a therapeutic benefit component in addition to or in lieu of the cleansing component. These articles have been found to be particularly useful for personal cleansing applications, namely for the skin and hair. Thus, the present invention further relates to methods of cleansing and conditioning the skin and hair utilizing the articles of the present invention.

  本发明涉及一种适用于清洁的基本干燥、一次性个人护理用品，该用品包括： a）一种水不溶性基材，包括一个褶皱无纺布层；和 b）位于所述褶皱无纺布层相邻的清洁成分，其中所述成分包括从水不溶性基材的重量约10％到约1000％的起泡表面活性剂，且所述清洁成分的对数[（&eegr; @ 25℃）/（&eegr; @ 200℃）]大于约0.45。 此外，本发明还涉及一种类似的用品，其特征在于清洁成分在25℃下测量的振荡应力大于约100 Pa·s的复杂黏度。本发明进一步涉及一种适用于调理的基本干燥、一次性个人护理用品，其中上述所述的用品包括治疗益处成分，位于所述水不溶性基材相邻的位置，其中所述成分包括从水不溶性基材的重量约10％到约1000％的治疗益处成分，除了或代替清洁成分。 已经发现这些用品在个人清洁应用中特别有用，即用于皮肤和头发。因此，本发明还涉及利用本发明的用品清洁和调理皮肤和头发的方法。

表征谱图