1,5-bis-(4-methoxyphenyl)-2,4-bis-(4-methylbenzoyl)pentane-1,5-dione

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 1,5-bis-(4-methoxyphenyl)-2,4-bis-(4-methylbenzoyl)pentane-1,5-dione
• 英文别名: 4-(4-Methoxybenzoyl)-1-(4-methoxyphenyl)-2-(4-methylbenzoyl)-5-(4-methylphenyl)pentane-1,5-dione；4-(4-methoxybenzoyl)-1-(4-methoxyphenyl)-2-(4-methylbenzoyl)-5-(4-methylphenyl)pentane-1,5-dione
• 化学式: C₃₅H₃₂O₆
• 分子量: 548.635
• InChiKey: NANQZMPJRWHZPH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.1
• 重原子数：
  41
• 可旋转键数：
  12
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  86.7
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  四甲基乙二胺 、 1-(4-methoxyphenyl)-3-(p-tolyl)propane-1,3-dione 在 dipotassium peroxodisulfate 作用下， 以 乙腈 为溶剂， 反应 5.0h， 以74%的产率得到1,5-bis-(4-methoxyphenyl)-2,4-bis-(4-methylbenzoyl)pentane-1,5-dione
  参考文献：
  名称：

  Oxidative C(Sp3)–H activation and C–N cleavage of N-methyl amines under transition-metal-free condition for synthesis of methylene-bridged bis-1,3-diketones

  摘要：

  A transition-metal-free oxidative methylenation reaction was developed. Methylene-bridged bis-1,3-dicarbonyl compounds were synthesized by oxidative C(Sp(3))-H activation and C-N cleavage of N-methyl amines. This novel reaction avoids the use of transition metal catalyst. Furthermore, the reaction are very mild and operational convenient. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2014.01.033

文献信息

• Oxidative C(Sp3)–H activation and C–N cleavage of N-methyl amines under transition-metal-free condition for synthesis of methylene-bridged bis-1,3-diketones
  作者：Xiaohu Wang、Yi Wang、Yu Yuan、Chun-Hui Xing

  DOI：10.1016/j.tet.2014.01.033

  日期：2014.3

  A transition-metal-free oxidative methylenation reaction was developed. Methylene-bridged bis-1,3-dicarbonyl compounds were synthesized by oxidative C(Sp(3))-H activation and C-N cleavage of N-methyl amines. This novel reaction avoids the use of transition metal catalyst. Furthermore, the reaction are very mild and operational convenient. (C) 2014 Elsevier Ltd. All rights reserved.