dodecylcarbamic acid phenyl ester

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: dodecylcarbamic acid phenyl ester
• 英文别名: N-phenoxycarbonyl-1-dodecylamine；phenyl N-dodecylcarbamate
• 化学式: C₁₉H₃₁NO₂
• 分子量: 305.461
• InChiKey: VXMFUQFJHWRHDL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.1
• 重原子数：
  22
• 可旋转键数：
  13
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.63
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  dodecylcarbamic acid phenyl ester 在 盐酸 、 一水合肼 作用下， 以 乙二醇二甲醚 、 二甲基亚砜 为溶剂， 反应 24.5h， 生成 N-dodecylisoquinoline-1-carboxamide
  参考文献：
  名称：

  肼甲酰胺对电子缺陷型氮杂芳烃的高度区域选择性氨基甲酰化

  摘要：

  通过缺电子氮杂芳烃的脱水肼Minisci反应，已确立了将肼甲酰胺用作新型氨基甲酰化剂的用途。各种电子不足的氮杂芳烃，包括异喹啉，喹啉，吡啶，菲啶，喹喔啉和邻苯二甲酰肼，用肼基甲酰胺盐酸盐进行铜/酸催化的氧化氨基甲酰化反应，制得结构多样的氮-杂芳基甲酰胺，可作为中等至最佳的单一区域异构体产量。奎宁的直接氨基甲酰化消除了涉及保护基团和杂环的预官能化的多步序列，从而充分证明了该功能基团的耐受性。

  DOI：

  10.1021/acs.orglett.7b02312
• 作为产物：
  描述：

  十二烷基伯胺 、 氯甲酸苯酯 在 吡啶 作用下， 以 二氯甲烷 为溶剂， 反应 3.0h， 生成 dodecylcarbamic acid phenyl ester
  参考文献：
  名称：

  肼甲酰胺对电子缺陷型氮杂芳烃的高度区域选择性氨基甲酰化

  摘要：

  通过缺电子氮杂芳烃的脱水肼Minisci反应，已确立了将肼甲酰胺用作新型氨基甲酰化剂的用途。各种电子不足的氮杂芳烃，包括异喹啉，喹啉，吡啶，菲啶，喹喔啉和邻苯二甲酰肼，用肼基甲酰胺盐酸盐进行铜/酸催化的氧化氨基甲酰化反应，制得结构多样的氮-杂芳基甲酰胺，可作为中等至最佳的单一区域异构体产量。奎宁的直接氨基甲酰化消除了涉及保护基团和杂环的预官能化的多步序列，从而充分证明了该功能基团的耐受性。

  DOI：

  10.1021/acs.orglett.7b02312

文献信息

• Phenylurethane compounds and methods for producing same, asymmetric urea compounds and methods for producing same, barbituric acid derivative, and diazo thermal recording material containing the derivative
  申请人：FUJI PHOTO FILM CO., LTD.

  公开号：US20020161225A1

  公开（公告）日：2002-10-31

  Phenylurethane compounds of the following general formula (1); asymmetric urea compounds of the following general formula (10) obtained from the phenylurethane compounds; barbituric acid derivatives of general formula (18) produced from the asymmetric urea compounds, which have specific substituents and are useful in diazo thermal recording materials; and diazo thermal recording materials containing the barbituric acid derivative. 1

  以下为翻译结果： 以下是具有以下通式（1）的苯基脲化合物；从苯基脲化合物获得的具有以下通式（10）的不对称脲化合物；从不对称脲化合物产生的具有特定取代基的巴比妥酸衍生物，可用于重氮热记录材料；以及含有巴比妥酸衍生物的重氮热记录材料。
• METHOD FOR TREATMENT OF ISOCYANATE RESIDUE, AND METHOD FOR TREATMENT OF CARBONATE
  申请人：Mitsui Chemicals, Inc.

  公开号：EP2518044A1

  公开（公告）日：2012-10-31

  A method for treating an isocyanate residue, which comprises carrying out a thermal decomposition reaction of a carbamate that is produced by the reaction among an amine, urea and/or an N-unsubstituted carbamic acid ester and an alcohol to produce a decomposition solution, separating an isocyanate and the alcohol from the decomposition solution to produce the isocyanate residue, and bringing the isocyanate residue into contact with high-pressure/high-temperature water to decompose the isocyanate residue into an amine; and a method for treating a carbonate, which comprises bringing the carbonate into contact with high-pressure/high-temperature water to decompose the carbonate into an alcohol.

  一种处理异氰酸酯残留物的方法，包括对氨基甲酸酯进行热分解反应，该氨基甲酸酯是由胺、尿素和/或 N-未取代氨基甲酸酯与醇反应生成的，从分解溶液中分离出异氰酸酯和醇，生成异氰酸酯残留物，将异氰酸酯残留物与高压/高温水接触，将异氰酸酯残留物分解成胺；一种处理碳酸盐的方法，包括使碳酸盐与高压/高温水接触，将碳酸盐分解成醇。
• The synthesis and biological evaluation of para-substituted phenolic N-alkyl carbamates as endocannabinoid hydrolyzing enzyme inhibitors
  作者：Anna Minkkilä、Mikko J. Myllymäki、Susanna M. Saario、Joel A. Castillo-Melendez、Ari M.P. Koskinen、Christopher J. Fowler、Jukka Leppänen、Tapio Nevalainen

  DOI：10.1016/j.ejmech.2009.01.007

  日期：2009.7

  A series of para-substituted phenolic N-alkyl carbamates were evaluated for their FAAH and MGL inhibitory activities. The compounds were generally selective for FAAH, with IC50 values in the nM range, whereas inhibition of MGL required concentrations three orders of magnitude higher. The most potent compounds, dodecylcarbamic acid 4-(4,5-dihydrothiazol-2-yl)phenyl (12) and 4-(1,2,3-thiadiazol-4-yl)phenyl (26) esters, inhibited FAAH and MGL with IC50 values at the low-nanomolar (IC(50)s: 0.0063 and 0.012 mu M) and the low-micromolar ranges (IC(50)s; 2.1 and 1.0 mu M), respectively. Compound 26 also inhibited both FAAH-dependent AEA uptake and AEA hydrolysis (IC50; 0.082 mu M) by intact RBL2H3 cells, and could also reduce 2-AG hydrolysis by these cells at concentrations >= 0.030 mu M. (C) 2009 Elsevier Masson SAS. All rights reserved.
• US6720421B2
  申请人：——

  公开号：US6720421B2

  公开（公告）日：2004-04-13
• Highly Regioselective Carbamoylation of Electron-Deficient Nitrogen Heteroarenes with Hydrazinecarboxamides
  作者：Zeng-Yang He、Chao-Fan Huang、Shi-Kai Tian

  DOI：10.1021/acs.orglett.7b02312

  日期：2017.9.15

  The use of hydrazinecarboxamides as a new class of carbamoylating agents has been established through the dehydrazinative Minisci reaction of electron-deficient nitrogen heteroarenes. A wide range of electron-deficient nitrogen heteroarenes, including isoquinoline, quinoline, pyridine, phenanthridine, quinoxaline, and phthalazine, underwent copper/acid-catalyzed oxidative carbamoylation with hydrazinecarboxamide

  通过缺电子氮杂芳烃的脱水肼Minisci反应，已确立了将肼甲酰胺用作新型氨基甲酰化剂的用途。各种电子不足的氮杂芳烃，包括异喹啉，喹啉，吡啶，菲啶，喹喔啉和邻苯二甲酰肼，用肼基甲酰胺盐酸盐进行铜/酸催化的氧化氨基甲酰化反应，制得结构多样的氮-杂芳基甲酰胺，可作为中等至最佳的单一区域异构体产量。奎宁的直接氨基甲酰化消除了涉及保护基团和杂环的预官能化的多步序列，从而充分证明了该功能基团的耐受性。