N-(4-(1-butenyl))-N-(3-(1-propenyl))benzamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(4-(1-butenyl))-N-(3-(1-propenyl))benzamide
• 英文别名: N-allyl-N-(but-3-en-1-yl)benzamide；N-but-3-enyl-N-prop-2-enylbenzamide
• 化学式: C₁₄H₁₇NO
• 分子量: 215.295
• InChiKey: IEZFAYCIPRIXLI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N-(4-(1-butenyl))-N-(3-(1-propenyl))benzamide 在 fluorous Grubbs-Hoveyda metathesis catalyst supported on Teflon powder 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 4.0h， 以100%的产率得到(5,6-dihydropyridin-1(2H)-yl)(phenyl)methanone
  参考文献：
  名称：

  A medium fluorous Grubbs–Hoveyda 2nd generation catalyst for phase transfer catalysis of ring closing metathesis reactions

  摘要：

  A fluorous Grubbs-Hoveyda metathesis catalyst supported on Teflon (R) powder, that readily moves between the solid phase (Teflon (R)) and the liquid phase (DMF) was prepared. By modulating the hydrophobicity of the reaction medium at the end of the reaction, the supported catalyst could be recovered by simple filtration even though the catalyst existed in a homogeneous state during the reaction. In RCM reactions, the catalyst could be reused up to three times with only a slight loss in reactivity with each subsequent cycle. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2015.01.097
• 作为产物：
  描述：

  N-羟基-N-甲基苯甲酰胺 在 2,6-二甲基吡啶 、 四氯化钛 、 sodium hydride 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 3.25h， 生成 N-(4-(1-butenyl))-N-(3-(1-propenyl))benzamide
  参考文献：
  名称：

  A Facile Preparation of N-(Isopropoxyalkyl) Amides by Generation and Trapping of N-Acyliminium Ions from Ionization-Rearrangement Reactions of N-Triflyloxy Amides

  摘要：

  A series of hydroxamic acids were converted to N-triflyloxy amides which were heated in 2-propanol to give N-(1-isopropoxyalkyl) amides in high yields. The method is simple, direct, and extremely tolerant of structural diversity both in the N-acyl group, as well as in the 1-isopropoxyalkyl group. N-Alkylation of secondary N-(1-isopropoxyalkyl) amides can be used for converting them to tertiary N-(1-isopropoxyalkyl) amides. N-Acyliminium ions of wide structural diversity can be generated easily from N-(1-isopropoxyalkyl) amides available by this methodology.

  DOI：

  10.1021/jo00092a007

文献信息

• A Facile Preparation of N-(Isopropoxyalkyl) Amides by Generation and Trapping of N-Acyliminium Ions from Ionization-Rearrangement Reactions of N-Triflyloxy Amides
  作者：Robert V. Hoffman、Naresh K. Nayyar

  DOI：10.1021/jo00092a007

  日期：1994.7

  A series of hydroxamic acids were converted to N-triflyloxy amides which were heated in 2-propanol to give N-(1-isopropoxyalkyl) amides in high yields. The method is simple, direct, and extremely tolerant of structural diversity both in the N-acyl group, as well as in the 1-isopropoxyalkyl group. N-Alkylation of secondary N-(1-isopropoxyalkyl) amides can be used for converting them to tertiary N-(1-isopropoxyalkyl) amides. N-Acyliminium ions of wide structural diversity can be generated easily from N-(1-isopropoxyalkyl) amides available by this methodology.
• A medium fluorous Grubbs–Hoveyda 2nd generation catalyst for phase transfer catalysis of ring closing metathesis reactions
  作者：Yuki Kobayashi、Sae Inukai、Natsuki Kondo、Tomoko Watanabe、Yuya Sugiyama、Hiromi Hamamoto、Takayuki Shioiri、Masato Matsugi

  DOI：10.1016/j.tetlet.2015.01.097

  日期：2015.3

  A fluorous Grubbs-Hoveyda metathesis catalyst supported on Teflon (R) powder, that readily moves between the solid phase (Teflon (R)) and the liquid phase (DMF) was prepared. By modulating the hydrophobicity of the reaction medium at the end of the reaction, the supported catalyst could be recovered by simple filtration even though the catalyst existed in a homogeneous state during the reaction. In RCM reactions, the catalyst could be reused up to three times with only a slight loss in reactivity with each subsequent cycle. (C) 2015 Elsevier Ltd. All rights reserved.