N-(1-phenylpropylidene)-2-chloroethylamine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(1-phenylpropylidene)-2-chloroethylamine
• 英文别名: N-(2-chloroethyl)-1-phenylpropan-1-imine
• 化学式: C₁₁H₁₄ClN
• 分子量: 195.692
• InChiKey: JRKINGQACTYEJQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  12.4
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2-氯乙胺盐酸盐 、 苯丙酮 在 四氯化钛 、 三乙胺 作用下， 以 N,N-二甲基甲酰胺 、 正戊烷 为溶剂， 反应 1.0h， 以89%的产率得到N-(1-phenylpropylidene)-2-chloroethylamine
  参考文献：
  名称：

  A Simple One-Pot Synthesis of Functionalized Ketimines from Ketones and Amine Hydrochloride Salts

  摘要：

  Functionalized ketimines of the general formula RR'C(=NCH2Y) [R and R' = Ph, alkyl; Y = CN (1), CH2Cl (2), COOMe (3)] have been prepared by the condensation of ketones with the corresponding primary amine hydrochloride salts [NH2CH2CN.HCl (4), NH2CH2CH2Cl.HCl (5) and NH2CH2COOMe.HCl (6), respectively]. The reported reaction proceeds mildly in a single step without the need of a previous isolation of the free amine from its salt. N,N-Dimethylformamide (DMF) is used as the solvent and TiCl4 as the drying agent.

  DOI：

  10.1080/00397919508011368

文献信息

• A Simple One-Pot Synthesis of Functionalized Ketimines from Ketones and Amine Hydrochloride Salts
  作者：M. Selva、P. Tundo、C. A. Marques

  DOI：10.1080/00397919508011368

  日期：1995.2

  Functionalized ketimines of the general formula RR'C(=NCH2Y) [R and R' = Ph, alkyl; Y = CN (1), CH2Cl (2), COOMe (3)] have been prepared by the condensation of ketones with the corresponding primary amine hydrochloride salts [NH2CH2CN.HCl (4), NH2CH2CH2Cl.HCl (5) and NH2CH2COOMe.HCl (6), respectively]. The reported reaction proceeds mildly in a single step without the need of a previous isolation of the free amine from its salt. N,N-Dimethylformamide (DMF) is used as the solvent and TiCl4 as the drying agent.