8-hydroxy-1,3,6-pyrenetrisulphonyl chloride

• 分子结构分类: 有机化合物 - 苯类化合物 - 芘
• 英文名称: 8-hydroxy-1,3,6-pyrenetrisulphonyl chloride
• 英文别名: 8-hydroxypyrene-1,3,6-trisulfonyl chloride
• 化学式: C₁₆H₇Cl₃O₇S₃
• 分子量: 513.784
• InChiKey: QEHRUXVBGUEEDB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  29
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  148
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  8-hydroxy-1,3,6-pyrenetrisulphonyl chloride 、 二正丁胺 以 四氢呋喃 为溶剂， 反应 24.0h， 以69%的产率得到
  参考文献：
  名称：

  HPTS系列衍生物及合成方法

  摘要：

  本发明公开了HPTS系列衍生物及合成方法，属于有机合成技术领域。所述HPTS系列衍生物是在HPTS的磺酸基团引入烷基胺或醇制备而成，合成方法包括以下步骤：1)将HPTS与三氯氧磷投入反应，在DMF催化作用下加热回流反应12h，得到反应产物；2)反应产物导入冰水中并搅拌，析出固体、抽滤，得到HPTS‑SO2Cl；3)将HPTS‑SO2Cl溶解于四氢呋喃中制备成溶液A，将烷基胺或醇溶解于四氢呋喃中制备成溶液B；将溶液A和溶液B混合后常温下反应24h，旋蒸得产品，经过柱分离后可获得纯化合物。该衍生物具有较强的脂溶性，克服了HPTS水溶性极强，应用范围受限的缺陷，拓宽了HPTS的应用范围。

  公开号：

  CN108610656B
• 作为产物：
  描述：

  8-hydroxy-1,3,6-pyrenetrisulfonic acid trisodium salt 在 N,N-二甲基甲酰胺 、 三氯氧磷 作用下， 反应 12.0h， 以90%的产率得到8-hydroxy-1,3,6-pyrenetrisulphonyl chloride
  参考文献：
  名称：

  HPTS系列衍生物及合成方法

  摘要：

  本发明公开了HPTS系列衍生物及合成方法，属于有机合成技术领域。所述HPTS系列衍生物是在HPTS的磺酸基团引入烷基胺或醇制备而成，合成方法包括以下步骤：1)将HPTS与三氯氧磷投入反应，在DMF催化作用下加热回流反应12h，得到反应产物；2)反应产物导入冰水中并搅拌，析出固体、抽滤，得到HPTS‑SO2Cl；3)将HPTS‑SO2Cl溶解于四氢呋喃中制备成溶液A，将烷基胺或醇溶解于四氢呋喃中制备成溶液B；将溶液A和溶液B混合后常温下反应24h，旋蒸得产品，经过柱分离后可获得纯化合物。该衍生物具有较强的脂溶性，克服了HPTS水溶性极强，应用范围受限的缺陷，拓宽了HPTS的应用范围。

  公开号：

  CN108610656B

文献信息

• Optical pH sensor
  申请人：Aller C. Robert

  公开号：US20060088722A1

  公开（公告）日：2006-04-27

  A new stable and reversible planar pH fluorosensor is prepared by conjugating a pH sensitive fluorescent material to a water soluble polymer chain attached to a support.

  一种新的稳定可逆平面pH荧光传感器通过将pH敏感荧光材料与附着在支撑物上的水溶性聚合物链结合来制备。
• Pyrenyloxysulfonic acid fluorescent agents
  申请人：Haugland Richard

  公开号：US20050123935A1

  公开（公告）日：2005-06-09

  The invention provides a novel class of reactive fluorescent agents that are based on a pyrene sulfonic acid nucleus. The agents are readily incorporated into conjugates with other species by reacting the reactive group with a group of complementary reactivity on the other species of the conjugate. Also provided are methods of using the compounds of the invention to detect and/or quantify an analyte in a sample. In an exemplary embodiment, the invention provides multi-color assays incorporating the compounds of the invention.

  本发明提供了一类基于芘磺酸核的新型活性荧光剂。通过使活性基团与共轭物中其他物质上具有互补反应性的基团反应，这些制剂很容易与其他物质结合成共轭物。此外，还提供了使用本发明化合物检测和/或量化样品中分析物的方法。在一个示例性实施方案中，本发明提供了包含本发明化合物的多色检测方法。
• PYRENYLOXYSULFONIC ACID FLURESCENT AGENTS
  申请人：Haugland Richard

  公开号：US20080032379A1

  公开（公告）日：2008-02-07

  The invention provides a novel class of reactive fluorescent agents that are based on a pyrene sulfonic acid nucleus. The agents are readily incorporated into conjugates with other species by reacting the reactive group with a group of complementary reactivity on the other species of the conjugate. Also provided are methods of using the compounds of the invention to detect and/or quantify an analyte in a sample. In an exemplary embodiment, the invention provides multi-color assays incorporating the compounds of the invention.
• Multilayered optical sensing patch and retaining plug therefor
  申请人：Kane James A.

  公开号：US20080286155A1

  公开（公告）日：2008-11-20

  A multilayered optical sensing patch, for the measurement of conditions, such as pH, oxygen level, etc, within containers, is provided. The multilayered optical sensing patch of the present invention is comprised of a heat sealable polymer substrate layer, and a polymeric sensing membrane later attached thereto. The polymer sensing membrane layer is formed of a porous polymer support membrane, and an optical sensing composition (comprising a reactive indicator) covalently bonded thereto. The heat sealable polymer substrate layer is capable of being securely bonded to the inner layer of bioreactor bags, as well as the porous polymer support substrate layer. Further, the porous polymer support membrane layer provides a firm supporting structure for the polymeric sensing layer, thereby protecting the optical sensing composition disposed therein from degradation/damage.
• PYRENYLOXYSULFONIC ACID FLUORESCENT AGENTS
  申请人：Haugland Richard

  公开号：US20120045848A1

  公开（公告）日：2012-02-23

  The invention provides a novel class of reactive fluorescent agents that are based on a pyrene sulfonic acid nucleus. The agents are readily incorporated into conjugates with other species by reacting the reactive group with a group of complementary reactivity on the other species of the conjugate. Also provided are methods of using the compounds of the invention to detect and/or quantify an analyte in a sample. In an exemplary embodiment, the invention provides multi-color assays incorporating the compounds of the invention.