N-<2-(1-3H-indenyl)ethyl>-p-toluenesulfonamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-<2-(1-3H-indenyl)ethyl>-p-toluenesulfonamide
• 英文别名: N-2-(1-indenyl)ethyl-toluenesulfonamide；N-[2-(3H-inden-1-yl)ethyl]-4-methylbenzenesulfonamide
• 化学式: C₁₈H₁₉NO₂S
• 分子量: 313.42
• InChiKey: CJQZTCXRXZSGPQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  54.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  N-甲苯磺酰基氮杂环丙烷 、 茚 在 正丁基锂 作用下， 以 四氢呋喃 为溶剂， 反应 17.0h， 以3.06 g的产率得到N-<2-(1-3H-indenyl)ethyl>-p-toluenesulfonamide
  参考文献：
  名称：

  N-[2-(1-3H-Indenyl)ethyl]-p-toluenesulfonamide

  摘要：

  Lithium indene reacts with N-p-toluenesulfonylaziridene to yield N-[2-(1-3H-indenyl)ethyl-p-roluenesulfonamide, C18H19NO2S. The structure consists of independent molecules with the indene group substituted at the expected 1 position of the five-membered ring. The sulfonamide moiety has a planar arrangement about the N atom.

  DOI：

  10.1107/s0108270195013011

文献信息

• Synthesis of chiral N-alkyl-cyclopentadienyl sulfonamides
  作者：Cornelis Lensink

  DOI：10.1016/0957-4166(95)00264-p

  日期：1995.8

  The reaction of sodium cyclopentadiene or lithium indene with tosylamino tosylates of amino alcohols yield a series of novel N-alkylcyclopentadiene sulfonamides. These cyclopentadiene derivatives are potential ligands capable of chelating to transition metals. Optically active derivatives were prepared starting from chiral beta-amino alcohols.
• N-[2-(1-3H-Indenyl)ethyl]-p-toluenesulfonamide
  作者：G. J. Gainsford、C. Lensink

  DOI：10.1107/s0108270195013011

  日期：1996.2.15

  Lithium indene reacts with N-p-toluenesulfonylaziridene to yield N-[2-(1-3H-indenyl)ethyl-p-roluenesulfonamide, C18H19NO2S. The structure consists of independent molecules with the indene group substituted at the expected 1 position of the five-membered ring. The sulfonamide moiety has a planar arrangement about the N atom.