4-mesitylphthalazine-1(2H)-thione

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 4-mesitylphthalazine-1(2H)-thione
• 英文别名: 4-(2,4,6-trimethylphenyl)-2H-phthalazine-1-thione
• 化学式: C₁₇H₁₆N₂S
• 分子量: 280.393
• InChiKey: TYJSYVMJQJKRGN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  20
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  56.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-mesitylphthalazine-1(2H)-thione 在 potassium carbonate 、 三乙胺 作用下， 以 甲醇 、 乙二醇二甲醚 为溶剂， 反应 1.0h， 生成 2-((4-mesitylphthalazin-1-ylthio)methoxy)ethanol
  参考文献：
  名称：

  Synthesis and antimicrobial activities of S-nucleosides of 4-mesitylphthalazine-1-thiol and some new selenium-containing nucleoside analogues

  摘要：

  A new series of selenium-containing nucleoside analogues, S-nucleosides and S-alkyl derivatives of 4-mesitylphthalazine-1(2H)-selenone and 4-mesitylphthalazine-1(2H)-thione is prepared using different halo compounds. Spectral (IR, H-1 NMR, C-13 NMR) data, and elemental analyses confirmed the structures of the newly synthesized compounds. The antimicrobial and analytical activities of the new compounds have been investigated. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2015.01.103
• 作为产物：
  描述：

  1-chloro-4-(2,4,6-trimethylphenyl)phthalazine 在 硫脲 作用下， 以 乙醇 为溶剂， 反应 6.0h， 以65%的产率得到4-mesitylphthalazine-1(2H)-thione
  参考文献：
  名称：

  Synthesis and antimicrobial activities of S-nucleosides of 4-mesitylphthalazine-1-thiol and some new selenium-containing nucleoside analogues

  摘要：

  A new series of selenium-containing nucleoside analogues, S-nucleosides and S-alkyl derivatives of 4-mesitylphthalazine-1(2H)-selenone and 4-mesitylphthalazine-1(2H)-thione is prepared using different halo compounds. Spectral (IR, H-1 NMR, C-13 NMR) data, and elemental analyses confirmed the structures of the newly synthesized compounds. The antimicrobial and analytical activities of the new compounds have been investigated. (C) 2015 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2015.01.103