(5-methyl-2-(2,4,6-trimethoxyphenyl)-1,3-dioxan-5-yl)methanol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: (5-methyl-2-(2,4,6-trimethoxyphenyl)-1,3-dioxan-5-yl)methanol
• 英文别名: (5-Methyl-2-(2,4,6-trimethoxyphenyl)-1,3-dioxan-5-yl)methanol；[5-methyl-2-(2,4,6-trimethoxyphenyl)-1,3-dioxan-5-yl]methanol
• 化学式: C₁₅H₂₂O₆
• 分子量: 298.336
• InChiKey: MVQBNMXGBUHPMY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  66.4
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  甲基丙烯酰氯 、 (5-methyl-2-(2,4,6-trimethoxyphenyl)-1,3-dioxan-5-yl)methanol 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 16.0h， 生成 (5-methyl-2-(2,4,6-trimethoxyphenyl)-1,3-dioxan-5-yl)methyl methacrylate
  参考文献：
  名称：

  Films and Particles

  摘要：

  本文描述了可用于制备基于聚合物的薄膜、颗粒、凝胶及相关组合物的化合物和工艺，以及用于传递药剂和其他用途的工艺。

  公开号：

  US20080075718A1
• 作为产物：
  描述：

  1,1,1-三(羟甲基)乙烷 、 2,4,6-三甲氧基苯甲醛 在 对甲苯磺酸 作用下， 以 四氢呋喃 为溶剂， 生成 (5-methyl-2-(2,4,6-trimethoxyphenyl)-1,3-dioxan-5-yl)methanol
  参考文献：
  名称：

  pH响应性两亲性二嵌段共聚物的酸可分解聚合物，用于细胞内药物递送。

  摘要：

  由能够与亲水性和疏水性有效载荷同时加载的两亲性聚合物自组装的超分子囊泡，也被称为聚合物囊泡，在药物递送应用中显示出有希望的潜力。在这里，我们报告通过两亲性二嵌段共聚物，聚（环氧乙烷）-b-聚（2-（（（（（5-甲基-2-（2,4,6-三甲氧基苯基）-1,3-二恶烷-5-基）甲氧基）羰基）氨基）甲基丙烯酸乙酯）（PEO- b-PTTAMA），是使用基于PEO的macroRAFT试剂通过pH响应单体（即TTAMA）的可逆加成-断裂链转移（RAFT）聚合合成的。然后，通过TEM和DLS测量证实，所得的两亲性二嵌段共聚物会自组装成由亲水性PEO电晕和pH响应性疏水性双层组成的囊泡。疏水性双层中含有环状亚苄基乙缩醛的聚合物囊泡在中性pH值下相对稳定，而在暴露于酸性pH值条件下，它们水解后会释放出疏水性2,4,6-三甲氧基苯甲醛并同时生成亲水性二醇部分，这可能通过紫外/可见光谱，SEM和TEM观察进行

  DOI：

  10.1021/acs.macromol.5b01709

文献信息

• EXPANSILE CROSSLINKED POLYMERSOME FOR PH-SENSITIVE DELIVERY OF ANTICANCER DRUGS
  申请人：Mayo Foundation for Medical Education and Research

  公开号：US20180098939A1

  公开（公告）日：2018-04-12

  This disclosure relates to polymersomes comprising a crosslinked polymer and their use as drug delivery vehicles. Specifically, polymersomes comprising a polymer of Formula I: wherein each R is independently C 1-6 alkyl; and n is an integer between 1 and 50.

  这份披露涉及到包含交联聚合物的聚合物囊泡及其作为药物传递载体的用途。具体来说，聚合物囊泡包括符合以下式I的聚合物： 其中每个R独立地是C1-6烷基；n是介于1和50之间的整数。
• Polymeric depots for localization of agent to biological sites
  申请人：TRUSTEES OF BOSTON UNIVERSITY

  公开号：US10251841B2

  公开（公告）日：2019-04-09

  Provided herein are polymeric particles and compounds and processes that can be used to prepare polymer-based particles and methods of using those particles to localize or concentrate a subsequently delivered agent to an in vivo site.

  本文提供了可以用于制备基于聚合物的颗粒的聚合物颗粒、化合物和过程，以及利用这些颗粒将随后传递的药剂定位或浓缩到体内部位的方法。
• Expansile crosslinked polymersome for pH-sensitive delivery of anticancer drugs
  申请人：Mayo Foundation for Medical Education and Research

  公开号：US10188606B2

  公开（公告）日：2019-01-29

  This disclosure relates to polymersomes comprising a crosslinked polymer and their use as drug delivery vehicles. Specifically, polymersomes comprising a polymer of Formula I: wherein each R is independently C1-6 alkyl; and n is an integer between 1 and 50.

  本公开涉及由交联聚合物组成的聚合体及其作为药物输送载体的用途。具体地说，是由式 I 的聚合物组成的聚合体： 其中每个 R 独立地为 C1-6 烷基；n 为 1 至 50 之间的整数。
• Expansile crosslinked polymersome for ph-sensitive delivery of anticancer drugs
  申请人：Mayo Foundation for Medical Education and Research

  公开号：US11040009B2

  公开（公告）日：2021-06-22

  This disclosure relates to polymersomes comprising a crosslinked polymer and their use as drug delivery vehicles. Specifically, polymersomes comprising a polymer of Formula I: wherein each R is independently C1-6 alkyl; and n is an integer between 1 and 50.

  本公开涉及由交联聚合物组成的聚合体及其作为药物输送载体的用途。具体地说，是由式 I 的聚合物组成的聚合体： 其中每个 R 独立地为 C1-6 烷基；n 为 1 至 50 之间的整数。
• Stimuli-Responsive Supramolecular Assemblies of Linear-Dendritic Copolymers
  作者：Elizabeth R. Gillies、Thomas B. Jonsson、Jean M. J. Fréchet

  DOI：10.1021/ja0463738

  日期：2004.9.1

  With the goal of developing a pH-responsive micelle system, linear-dendritic block copolymers comprising poly(ethylene oxide) and either a polylysine or polyester dendron were prepared and hydrophobic groups were attached to the dendrimer periphery by highly acid-sensitive cyclic acetals. These copolymers were designed to form stable micelles in aqueous solution at neutral pH but to disintegrate into unimers at mildly acidic pH following loss of the hydrophobic groups upon acetal hydrolysis. Micelle formation was demonstrated by encapsulation of the fluorescent probe Nile Red, and the micelle sizes were determined by dynamic light scattering. The structure of the dendrimer block, its generation, and the synthetic method for linking the acetal groups to its periphery all had an influence on the critical micelle concentration and the micelle size. The rate of hydrolysis of the acetals at the micelle core was measured for each system at pH 7.4 and pH 5, and it was found that all systems were stable at neutral pH but underwent significant hydrolysis at pH 5 over several hours. The rate of hydrolysis at pH 5 was dependent on the structure of the copolymer, most notably the hydrophobicity of the core-forming block. To demonstrate the potential of these systems for controlled release, the release of Nile Red as a "model payload" was examined. At pH 7.4, the fluorescence of micelle-encapsulated Nile Red was relatively constant, indicating it was retained in the micelle, while at pH 5, the fluorescence decreased, consistent with its release into the aqueous environment. The rate of release was strongly correlated with the rate of acetal hydrolysis and was therefore controlled by the chemical structure of the copolymer. The mechanism of Nile Red release was investigated by monitoring the change in size of the micelles over time at acidic pH. Dynamic light scattering measurement showed a size decrease over time, eventually reaching the size of a unimer, thus providing evidence for the proposed micelle disintegration.