5-[2]furyl-2-phenyl-1,2-dihydro-pyrazol-3-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-[2]furyl-2-phenyl-1,2-dihydro-pyrazol-3-one
• 英文别名: 5-[2]Furyl-2-phenyl-1,2-dihydro-pyrazol-3-on；3-(furan-2-yl)-1-phenyl-1H-pyrazol-5-ol；5-(furan-2-yl)-2-phenyl-1H-pyrazol-3-one
• 化学式: C₁₃H₁₀N₂O₂
• 分子量: 226.235
• InChiKey: ZBHVSBDOLDEVJU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  45.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  显色基艳黄 R 、 5-[2]furyl-2-phenyl-1,2-dihydro-pyrazol-3-one 生成 5-[2]furyl-2-phenyl-2H-pyrazole-3,4-dione-4-((Z)-2-chloro-phenylhydrazone)
  参考文献：
  名称：

  Dal Monte; Casoni, Bollettino Scientifico della Facolta di Chimica Industriale di Bologna, 1951, vol. 9, p. 4,5, 6

  摘要：

  DOI：
• 作为产物：
  描述：

  2-呋喃甲基乙酯 在 sodium 作用下， 生成 5-[2]furyl-2-phenyl-1,2-dihydro-pyrazol-3-one
  参考文献：
  名称：

  Torrey; Zanetti, American Chemical Journal, 1906, vol. 36, p. 542

  摘要：

  DOI：

文献信息

• Sandelin, Chemische Berichte, 1900, vol. 33, p. 493
  作者：Sandelin

  DOI：——

  日期：——
• Azomethine Dyes. I. Color and Constitution of Pyrazolone Azomethine Dyes
  作者：G. H. Brown、B. Graham、P. W. Vittum、A. Weissberger

  DOI：10.1021/ja01147a011

  日期：1951.3
• Cobalt doped ZnS nanoparticles as a recyclable catalyst for solvent-free synthesis of heterocyclic privileged medicinal scaffolds under infrared irradiation
  作者：Anshu Dandia、Vijay Parewa、Shyam L. Gupta、Kuldeep S. Rathore

  DOI：10.1016/j.molcata.2013.02.010

  日期：2013.7

  This paper reports preparation and characterization of cobalt doped ZnS NPs and their catalytic application in the synthesis of heterocyclic privileged medicinal scaffolds involving pyrazolones (with excellent regioselectivity) and 1,3-oxathiolan-5-one frameworks under infrared irradiation. Nanoparticles have been prepared at room temperature by a wet chemical method. The heterogeneous catalysts were fully characterized by XRD, TEM, EDAX, ICP-AES and UV/Vis. Under infrared radiation (IR), the catalytic activity of Co doped ZnS NPs was about 40-fold higher under IR as compared to the conventional method. Nanocatalyst plays a dual role of catalyst as well as susceptor, and enhances the overall capacity to absorb IR in the reaction mixture. Doping by Co promotes the activity and selectivity of ZnS NPs as indicated by their high TOF value, providing the products with good to excellent yields. The surface acidity of NPs was measured by FTIR spectra of chemisorbed pyridine. The present method does not involve any hazardous organic solvent or catalyst. The introduction of nanocatalyst in an IR system offers promising features for the reaction response such as the shorter reaction time, simple work-up procedure, and purification of products by non-chromatographic methods. The catalyst was reused up to four runs without an appreciable loss of catalytic activity. (C) 2013 Elsevier B.V. All rights reserved.
• Dyestuffs and dyestuff intermediates
  申请人：ILFORD LTD

  公开号：US02394068A1

  公开（公告）日：1946-02-05
• Dal Monte Casoni, Gazzetta Chimica Italiana, 1955, vol. 85, p. 404,412
  作者：Dal Monte Casoni

  DOI：——

  日期：——