A palladium-catalyzed three-component carbonylative reaction for the synthesis of 3H-1,2,4-triazol-3-ones from hydrazonoyl chlorides and NaN3 has been achieved. The reaction presumably proceeds through a cascadecarbonylation, acyl azide formation, Curtius rearrangement, and intramolecular nucleophilic addition sequence. A wide variety of structurally diverse 3H-1,2,4-triazol-3-ones were constructed
已实现了钯催化的三组分羰基化反应,该反应可从酰氯和NaN 3合成3 H -1,2,4-三唑-3-酮。该反应大概通过级联羰基化,酰基叠氮化物形成,Curtius重排和分子内亲核加成序列进行。以中等至优异的产率构建了各种结构多样的3 H -1,2,4-三唑-3-酮。1,2,3,5-三甲酸三苯酯(TFBen)被用作固体和方便的一氧化碳替代物。