(N-Benzyloxycarbonyl-phenylalanyl)-diazomethan

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (N-Benzyloxycarbonyl-phenylalanyl)-diazomethan
• 英文别名: benzyl N-(4-diazo-3-oxo-1-phenylbutan-2-yl)carbamate
• 化学式: C₁₈H₁₇N₃O₃
• 分子量: 323.351
• InChiKey: WLGLEWHRLFWXLX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  24
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  57.4
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  (N-Benzyloxycarbonyl-phenylalanyl)-diazomethan 在 silver benzoate 作用下， 以 1,4-二氧六环 、 水 为溶剂， 反应 6.0h， 以83%的产率得到3-(benzyloxycarbonylamino)-4-phenylbutanoic acid
  参考文献：
  名称：

  Synthesis of enantiopure free and N-benzyloxycarbonyl-protected 3-substituted homotaurines from naturally occurring amino acids

  摘要：

  Enantiopure N-benzyloxycarbonyl-protected and free 3-substituted homotaurines were synthesized from naturally occurring amino acids via N-benzyloxycarbonyl protection, Arndt-Eistert homologation, reduction, esterification with thioacetic acid, and oxidation with performic acid. The current method is a convenient, practical, and salt-free method for the synthesis of enantiopure 3-substituted homotaurine with moderate to good yields. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2014.05.098
• 作为产物：
  描述：

  Cbz-DL-苯丙氨酸 在 N-甲基吗啉 作用下， 以 四氢呋喃 、 乙醚 为溶剂， 反应 0.25h， 生成 (N-Benzyloxycarbonyl-phenylalanyl)-diazomethan
  参考文献：
  名称：

  Synthesis of enantiopure free and N-benzyloxycarbonyl-protected 3-substituted homotaurines from naturally occurring amino acids

  摘要：

  Enantiopure N-benzyloxycarbonyl-protected and free 3-substituted homotaurines were synthesized from naturally occurring amino acids via N-benzyloxycarbonyl protection, Arndt-Eistert homologation, reduction, esterification with thioacetic acid, and oxidation with performic acid. The current method is a convenient, practical, and salt-free method for the synthesis of enantiopure 3-substituted homotaurine with moderate to good yields. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2014.05.098

文献信息

• Amino thiol dipeptides
  申请人：E.R. Squibb & Sons, Inc.

  公开号：EP0158947A2

  公开（公告）日：1985-10-23

  Amino thiol substituted dipeptides of the formula are disclosed. These compounds are useful as hypotensive agents due to their angiotensin coverting enzyme inhibition activity and are also useful as analgesics due to enkephalinase inhibition activity when X is

  式中硫醇取代的氨基二肽 的氨基硫醇取代二肽已被公开。这些化合物由于具有血管紧张素覆盖酶抑制活性而可用作降血压药，并且由于具有脑啡肽酶抑制活性而可用作镇痛药。
• US4500518A
  申请人：——

  公开号：US4500518A

  公开（公告）日：1985-02-19
• US4558150A
  申请人：——

  公开号：US4558150A

  公开（公告）日：1985-12-10