(S)-2-hydroxy-2-phenyl-propionamidine | 109595-37-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (S)-2-hydroxy-2-phenyl-propionamidine
• 英文别名: (S)-2-Hydroxy-2-phenyl-propionamidin；(2S)-2-hydroxy-2-phenylpropanimidamide
• CAS: 109595-37-1
• 化学式: C₉H₁₂N₂O
• 分子量: 164.207
• InChiKey: ZVYWQFCGNWHABY-VIFPVBQESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  70.1
• 氢给体数：
  3
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  α-hydroxy-α-phenylpropionic acid amidine 在 扁桃酸 作用下， 生成 (S)-2-hydroxy-2-phenyl-propionamidine
  参考文献：
  名称：

  The free radial forearm flap for reconstruction of facial defects in noma patients

  摘要：

  Within a 2-year period ten patients aged 5-22 years were treated for facial sequelae of noma. In six cases free radial forearm flaps were used, combined with local and regional flaps. The indications were defects located in the midface and perioral area. There were no free or regional flap losses in this series. The aesthetic and functional results were appreciated by the patients and there were no functional problems related to the donor area because a suprafascial flap dissection technique was used. In our experience the free radial forearm flap is a valuable option for facial reconstruction in NOMA cases. The advantages include: (1) A very long and large calibre pedicle; (2) thin and pliable flaps of variable size and configuration; (3) the possibility of single stage reconstruction in selected cases. The disadvantages include the not always ideal colour match, both in black patients and in white, and the unsightly donor area which, however, has never led to functional problems.

  DOI：

  10.1007/pl00006052

文献信息

• The free radial forearm flap for reconstruction of facial defects in noma patients
  作者：G. Noever、R. Feurer

  DOI：10.1007/pl00006052

  日期：2000.1.14

  Within a 2-year period ten patients aged 5-22 years were treated for facial sequelae of noma. In six cases free radial forearm flaps were used, combined with local and regional flaps. The indications were defects located in the midface and perioral area. There were no free or regional flap losses in this series. The aesthetic and functional results were appreciated by the patients and there were no functional problems related to the donor area because a suprafascial flap dissection technique was used. In our experience the free radial forearm flap is a valuable option for facial reconstruction in NOMA cases. The advantages include: (1) A very long and large calibre pedicle; (2) thin and pliable flaps of variable size and configuration; (3) the possibility of single stage reconstruction in selected cases. The disadvantages include the not always ideal colour match, both in black patients and in white, and the unsightly donor area which, however, has never led to functional problems.