ethyl 1-[(2R)-2-hydroxypropyl]-5-(trifluoromethyl)pyrazole-4-carboxylate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: ethyl 1-[(2R)-2-hydroxypropyl]-5-(trifluoromethyl)pyrazole-4-carboxylate
• 化学式: C₁₀H₁₃F₃N₂O₃
• 分子量: 266.22
• InChiKey: WYVMFZZQGMWQDL-ZCFIWIBFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  64.4
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• 1-(4-(ISOXAZOL-5-YL)-1H-PYRAZOL-1-YL)-2-METHYLPROPAN-2-OL DERIVATIVES AND RELATED COMPOUNDS AS IL-7 AND IFN-GAMMA INHIBITORS FOR TREATING AUTOIMMUNE DISEASES AND CHRONIC INFLAMMATION
  申请人：Immunic AG

  公开号：EP4074708A1

  公开（公告）日：2022-10-19

  The present invention relates to compounds of the general formula (I), and the pharmaceutically acceptable salts and solvates thereof, wherein Ar, Z and Y are as described herein and R1 is a group of the structure wherein n is 0 or 1; R2 is H, deuterium or methyl; R3 is methyl, trifluoromethyl, ethyl, or taken with R2 together forms a cyclopropyl group, or R3 forms a methylene bridge to the carbon atom marked ∗, which are suitable for the treatment of autoimmune diseases and chronic inflammation.

  本发明涉及通式 (I) 的化合物及其药学上可接受的盐和溶液，其中 Ar、Z 和 Y 如本文所述，R1 是结构式如下的基团 其中 n 为 0 或 1；R2 为 H、氘或甲基；R3 为甲基、三氟甲基、乙基，或与 R2 共同形成环丙基，或 R3 与标记为 ∗ 的碳原子形成亚甲基桥，这些化合物适用于治疗自身免疫性疾病和慢性炎症。
• IL-17 and IFN-gamma inhibition for the treatment of autoimmune diseases and chronic inflammation
  申请人：Immunic AG

  公开号：US20210061796A1

  公开（公告）日：2021-03-04

  The present invention relates to compounds of the general formula (I), and the pharmaceutically acceptable salts and solvates thereof, wherein Ar, Z and Y are as described herein and R1 is a group of the structure wherein n is 0 or 1; R2 is H, deuterium or methyl; R3 is methyl, trifluoromethyl, ethyl, or taken with R2 together forms a cyclopropyl group, or R3 forms a methylene bridge to the carbon atom marked *, which are suitable for the treatment of autoimmune diseases and chronic inflammation.