1-[(2R)-2-hydroxypropyl]-5-(trifluoromethyl)pyrazole-4-carboxylic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 1-[(2R)-2-hydroxypropyl]-5-(trifluoromethyl)pyrazole-4-carboxylic acid
• 化学式: C₈H₉F₃N₂O₃
• 分子量: 238.16
• InChiKey: GCSYIPXYLJMXDT-SCSAIBSYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  75.4
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• 1-(4-(ISOXAZOL-5-YL)-1H-PYRAZOL-1-YL)-2-METHYLPROPAN-2-OL DERIVATIVES AND RELATED COMPOUNDS AS IL-7 AND IFN-GAMMA INHIBITORS FOR TREATING AUTOIMMUNE DISEASES AND CHRONIC INFLAMMATION
  申请人：Immunic AG

  公开号：EP3679034B1

  公开（公告）日：2022-06-01
• IL-17 and IFN-gamma inhibition for the treatment of autoimmune diseases and chronic inflammation
  申请人：Immunic AG

  公开号：US20210061796A1

  公开（公告）日：2021-03-04

  The present invention relates to compounds of the general formula (I), and the pharmaceutically acceptable salts and solvates thereof, wherein Ar, Z and Y are as described herein and R1 is a group of the structure wherein n is 0 or 1; R2 is H, deuterium or methyl; R3 is methyl, trifluoromethyl, ethyl, or taken with R2 together forms a cyclopropyl group, or R3 forms a methylene bridge to the carbon atom marked *, which are suitable for the treatment of autoimmune diseases and chronic inflammation.