5-isopropyl-3-(trifluoromethyl)pyridin-2-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 5-isopropyl-3-(trifluoromethyl)pyridin-2-amine
• 英文别名: 5-Isopropyl-3-(trifluoromethyl)pyridin-2-amine；5-propan-2-yl-3-(trifluoromethyl)pyridin-2-amine
• 化学式: C₉H₁₁F₃N₂
• 分子量: 204.195
• InChiKey: CEARPYCQWAQHMH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  38.9
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  5-isopropyl-3-(trifluoromethyl)pyridin-2-amine 在 三乙胺 作用下， 以 二氯甲烷 、 丙酮 为溶剂， 反应 3.0h， 生成 5-isopropoxy-N-((5-isopropyl-3-(trifluoromethyl)pyridin-2-yl)carbamothioyl)picolinimidamide
  参考文献：
  名称：

  [EN] HETEROCYCLIC COMPOUNDS AND THEIR USE FOR TREATMENT OF HELMINTHIC INFECTIONS AND DISEASES
  [FR] COMPOSÉS HÉTÉROCYCLIQUES ET LEUR UTILISATION POUR LE TRAITEMENT D'INFECTIONS ET DE MALADIES HELMINTHIQUES

  摘要：

  本文提供了式（I）的杂环化合物及其药学上可接受的盐、互变异构体、同位素同分异构体或立体异构体，其中W、X、Y、R1、R2和RN如本文所定义，包括有效量的杂环化合物的组合物，以及治疗或预防动物和人类丝虫感染和疾病的方法。

  公开号：

  WO2020219871A1
• 作为产物：
  描述：

  2-氨基-3-三氟甲基吡啶 在 (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride 、 N-溴代丁二酰亚胺(NBS) 、 palladium 10% on activated carbon 、 氢气 、 potassium carbonate 作用下， 以 四氢呋喃 、 1,4-二氧六环 、 甲醇 、 水 为溶剂， 80.0 ℃ 、103.42 kPa 条件下， 反应 22.5h， 生成 5-isopropyl-3-(trifluoromethyl)pyridin-2-amine
  参考文献：
  名称：

  [EN] HETEROCYCLIC COMPOUNDS AND THEIR USE FOR TREATMENT OF HELMINTHIC INFECTIONS AND DISEASES
  [FR] COMPOSÉS HÉTÉROCYCLIQUES ET LEUR UTILISATION POUR LE TRAITEMENT D'INFECTIONS ET DE MALADIES HELMINTHIQUES

  摘要：

  本文提供了式（I）的杂环化合物及其药学上可接受的盐、互变异构体、同位素同分异构体或立体异构体，其中W、X、Y、R1、R2和RN如本文所定义，包括有效量的杂环化合物的组合物，以及治疗或预防动物和人类丝虫感染和疾病的方法。

  公开号：

  WO2020219871A1

文献信息

• HETEROCYCLIC COMPOUNDS AND THEIR USE FOR TREATMENT OF HELMINTHIC INFECTIONS AND DISEASES
  申请人：Celgene Corporation

  公开号：EP3959207A1

  公开（公告）日：2022-03-02
• QUINOLONE COMPOUND
  申请人：OTSUKA PHARMACEUTICAL CO., LTD.

  公开号：US20170362180A1

  公开（公告）日：2017-12-21

  The present invention provides a compound represented by the formula (I) wherein X is a hydrogen atom or a fluorine atom; R is a hydrogen atom or alkyl; R 1 is (1) cyclopropyl optionally substituted by 1 to 3 halogen atoms or (2) phenyl optionally substituted by 1 to 3 halogen atoms; R 2 is alkyl, alkoxy, haloalkoxy, a halogen atom, cyano, etc.; and R 3 is 7-oxo-7,8-dihydro-1,8-naphthyridinyl, 3-pyridyl, etc., or a salt thereof. The compound of the present invention has excellent antimicrobial activity against Clostridium difficile and is useful for the prevention or treatment of intestinal infection such as Clostridium difficile -associated diarrhea.
• TRICYCLIC DLK INHIBITORS AND USES THEREOF
  申请人：Genentech, Inc.

  公开号：US20170369510A1

  公开（公告）日：2017-12-28

  The invention relates to compounds of formula (I) and salts thereof: wherein ring A and R 1 -R 2 have any of the values defined in the specification. The compounds and salts are useful for treating DLK mediated disorders. The invention also provides pharmaceutical compositions comprising a compound of formula (I), or a pharmaceutically acceptable salt thereof, as well as methods of using said compounds, salts, or compositions as DLK inhibitors and for treating neurodegeneration diseases and disorders.
• SUBSTITUTED AMINOBENZYL HETEROARYL COMPOUNDS AS EGFR AND/OR PI3K INHIBITORS
  申请人：Mekanistic Therapeutics LLC

  公开号：US20220213054A1

  公开（公告）日：2022-07-07

  This disclosure is in the field of medicinal chemistry, and relates to a new class of small-molecules having the Formula I, or a pharmaceutically acceptable salt or solvate thereof, or an enantiomer, a mixture of enantiomers, a mixture of two or more diastereomers, or an isotopic variant thereof, wherein the variables Ring A, X, R 1a , R 1b , R 2 , R 3 , R 4 , m, n, and p are described herein, which function as dual inhibitors of EGFR proteins and PI3K proteins. The disclosure further relates to the use of the compounds described herein as therapeutics for the treatment of diseases and conditions mediated by EGFR proteins and/or PI3K proteins, such as cancer and other diseases.
• US8815918B2
  申请人：——

  公开号：US8815918B2

  公开（公告）日：2014-08-26