ethyl 5-methyl-2-heptenoate

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: ethyl 5-methyl-2-heptenoate
• 英文别名: ethyl (E)-5-methylhept-2-enoate
• 化学式: C₁₀H₁₈O₂
• 分子量: 170.252
• InChiKey: IVILHIDILKFOIB-SOFGYWHQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  12
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  磷酰基乙酸三乙酯 、 3-甲基-1-戊醛 以 正己烷 、 甲乙醚 、 水 为溶剂， 以61%的产率得到ethyl 5-methyl-2-heptenoate
  参考文献：
  名称：

  Method of treating cartilage damage

  摘要：

  该发明涉及通过给予类似GABA的类似物，例如Formula1的化合物及其药学上可接受的盐，来预防或治疗软骨损伤的方法，其中R1是氢或直链或支链低碳烷基，n为4至6的整数。

  公开号：

  US20020072533A1

文献信息

• Mono-and disubstituted 3-propyl gamma-aminobutyric acids
  申请人：——

  公开号：US20030181523A1

  公开（公告）日：2003-09-25

  The instant invention is a series of novel mono- and disubstituted 3-propyl gamma aminobutyric acids of Formula I 1 The compounds are useful as therapeutic agents in the treatment of epilepsy, faintness attacks, hypokinesia, cranial disorders, neurodegenerative disorders, depression, anxiety, panic, pain, neuropathological disorders, arthritis, sleep disorders, IBS, and gastric damage. Methods of preparing the compounds and useful intermediates are also part of the invention.

  这项即时发明是一系列新颖的单取代和双取代的Formula I的3-丙基γ-氨基丁酸。这些化合物在治疗癫痫、晕厥发作、运动减少、头颅疾病、神经退行性疾病、抑郁症、焦虑症、恐慌、疼痛、神经病理性疾病、关节炎、睡眠障碍、肠易激综合征和胃损伤方面是有用的治疗剂。制备这些化合物和有用中间体的方法也是该发明的一部分。
• Method of treating cartilage damage
  申请人：——

  公开号：US20020072533A1

  公开（公告）日：2002-06-13

  The invention relates to a method of preventing or treating cartilage damage by administering a GABA analog such as, for example, a compound of Formula 1 and pharmaceutically acceptable salts thereof, wherein R 1 is hydrogen or straight or branched lower alkyl, and n is an integer of from 4 to 6.

  该发明涉及通过给予类似GABA的类似物，例如Formula1的化合物及其药学上可接受的盐，来预防或治疗软骨损伤的方法，其中R1是氢或直链或支链低碳烷基，n为4至6的整数。
• Method of treating tinnitus
  申请人：——

  公开号：US20030176504A1

  公开（公告）日：2003-09-18

  The invention relates to a method of treating tinnitus by administering an alpha2delta ligand such as, for example, a compound of Formula 1 and pharmaceutically acceptable salts thereof, wherein R 1 is hydrogen or straight or branched lower alkyl, and n is an integer of from 4 to 6.

  这项发明涉及通过给予α2δ配体治疗耳鸣的方法，例如，给予一种符合化学式1的化合物及其药用盐，其中R1是氢或直链或支链低碳烷基，n为4至6的整数。
• [EN] PREGABALIN DERIVATIVES FOR THE TREATMENT OF FIBROMYALGIA AND OTHER DISORDERS<br/>[FR] DERIVES DE PREGABALIN POUR LE TRAITEMENT DE LA FIBROMYALGIE ET D'AUTRES TROUBLES
  申请人：WARNER LAMBERT CO

  公开号：WO2004054566A1

  公开（公告）日：2004-07-01

  This invention relates to a method of treating a disorder selected from OCD, agoraphobia, agoraphobia without history of panic disorder, specific phobia, social phobia, PTSD, restless legs syndrome, premenstrual dysphoric disorder, hot flashes, and fibromyalgia by administering a compound of the formula (1), or a pharmaceutically acceptable salt thereof, wherein; a) R1 is hydrogen, straight or branched alkyl of from 1 to 6 carbon atoms or phenyl; and b) R2 is straight or branched alkyl of from 4 to 8 carbon atoms, straight or branched alkenyl of from 2 to 8 carbon atoms, cycloalkyl of from 3 to 7 carbon atoms, alkoxy of from 1 to 6 carbon atoms, -alkylcycloalkyl, -alkylalkoxy, -alkyl OH, -alkylphenyl, -alkylphenoxy, or -substituted phenyl. The invention also relates to a method of treating the above disorders by administering the compound (3S, 5R)-3-Aminomethyl-5-methyl-octanoic acid.

  本发明涉及一种通过给予化合物（1）或其药学上可接受的盐来治疗选择自强迫症、广场恐惧症、无惊恐症状的广场恐惧症、特定恐惧症、社交恐惧症、创伤后应激障碍、不宁腿综合症、经前期情感性障碍、潮热和纤维肌痛等疾病的方法；其中：a）R1为氢、1至6个碳原子的直链或支链烷基或苯基；b）R2为4至8个碳原子的直链或支链烷基、2至8个碳原子的直链或支链烯基、3至7个碳原子的环烷基、1至6个碳原子的烷氧基、-烷基环烷基、-烷基烷氧基、-烷基羟基、-烷基苯基、-烷基苯氧基或-取代苯基。本发明还涉及一种通过给予化合物（3S，5R）-3-氨甲基-5-甲基-辛酸来治疗上述疾病的方法。
• Alpha 2 Delta Ligands For Fibromyalgia and Other Disorders
  申请人：Dooley David James

  公开号：US20080207755A1

  公开（公告）日：2008-08-28

  This invention relates to a method of treating certain disorders by administering a compound of the formula 1 or a pharmaceutically acceptable salt thereof, wherein: R 1 is hydrogen, straight or branched alkyl of from 1 to 6 carbon atoms or phenyl; and R 2 is straight or branched alkyl of from 4 to 8 carbon atoms, straight or branched alkenyl of from 2 to 8 carbon atoms, cycloalkyl of from 3 to 7 carbon atoms, alkoxy of from 1 to 6 carbon atoms, -alkylcycloalkyl, -alkylalkoxy, -alkyl OH, -alkylphenyl, -alkylphenoxy, or -substituted phenyl. The invention also relates to a method of treating the above disorders by administering the compound (3S, 5R)-3-aminomethyl-5-methyl-octanoic acid.

  本发明涉及一种通过给予公式1化合物或其药学上可接受的盐来治疗某些疾病的方法，其中：R1是氢、1至6个碳原子的直链或支链烷基或苯基；R2是4至8个碳原子的直链或支链烷基、2至8个碳原子的直链或支链烯基、3至7个碳原子的环烷基、1至6个碳原子的烷氧基、-烷基环烷基、-烷基烷氧基、-烷基羟基、-烷基苯基、-烷基苯氧基或-取代苯基。本发明还涉及一种通过给予化合物(3S, 5R)-3-氨甲基-5-甲基-辛酸来治疗上述疾病的方法。