O,O′-diethyl S-[1,3-bis(4-methoxyphenyl)-3-oxopropyl] phosphorothioate

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: O,O′-diethyl S-[1,3-bis(4-methoxyphenyl)-3-oxopropyl] phosphorothioate
• 英文别名: (3R)-3-diethoxyphosphorylsulfanyl-1,3-bis(4-methoxyphenyl)propan-1-one
• 化学式: C₂₁H₂₇O₆PS
• 分子量: 438.482
• InChiKey: BQXHCGCAIYQAGS-OAQYLSRUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  29
• 可旋转键数：
  12
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  96.4
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  O,O′-diethyl S-[1,3-bis(4-methoxyphenyl)-3-oxopropyl] phosphorothioate 在 N-[3,5-二(三氟甲基)苯基]-N-[(9R)-6-甲氧基-9-二奎宁基]硫脲 、 碳酸氢钠 作用下， 以 水 、 甲苯 为溶剂， 反应 24.0h， 以75%的产率得到
  参考文献：
  名称：

  Bifunctional Thiourea-Catalyzed Stereoablative Retro-Sulfa-Michael Reaction: Concise and Diastereoselective Access to Chiral 2,4-Diarylthietanes

  摘要：

  Owing to the chiral recognition capacity of bifunctional thioureas, a stereoablative retro-sulfa-Michael reaction has been developed. Utilization of a biphasic system enabled us to render the process catalytic. The usefulness of this methodology was further illustrated by the diastereoselective synthesis of all possible stereoisomers of 2,4-diarylthiethanes.

  DOI：

  10.1055/s-0036-1588612

文献信息

• Bifunctional Thiourea-Catalyzed Stereoablative Retro-Sulfa-Michael Reaction: Concise and Diastereoselective Access to Chiral 2,4-Diarylthietanes
  作者：Tibor Soós、András Bacsó、Mariann Szigeti、Szilárd Varga

  DOI：10.1055/s-0036-1588612

  日期：——

  Owing to the chiral recognition capacity of bifunctional thioureas, a stereoablative retro-sulfa-Michael reaction has been developed. Utilization of a biphasic system enabled us to render the process catalytic. The usefulness of this methodology was further illustrated by the diastereoselective synthesis of all possible stereoisomers of 2,4-diarylthiethanes.