(S)-(1,11-dimethoxy-5,7-dioxa-6-phospha-dibenzo[a,c]-cyclohepten-6-yl)dimethylamine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: (S)-(1,11-dimethoxy-5,7-dioxa-6-phospha-dibenzo[a,c]-cyclohepten-6-yl)dimethylamine
• 英文别名: 1,11-dimethoxy-N,N-dimethylbenzo[d][1,3,2]benzodioxaphosphepin-6-amine
• 化学式: C₁₆H₁₈NO₄P
• 分子量: 319.297
• InChiKey: PJUDSDOCOQUISF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  48
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  三(二甲胺基)膦 、 2-(2-羟基-6-甲氧基苯基)-3-甲氧基苯酚 在 ammonium chloride 作用下， 以 苯 为溶剂， 反应 16.0h， 以85%的产率得到(S)-(1,11-dimethoxy-5,7-dioxa-6-phospha-dibenzo[a,c]-cyclohepten-6-yl)dimethylamine
  参考文献：
  名称：

  使用单齿亚磷酰胺配体，铑催化硼酸的不对称共轭加成。

  摘要：

  单齿亚磷酰胺首次用作芳基硼酸在Rh催化的对映体的对映体选择性共轭加成反应中的手性配体，所述的方法是将芳族硼酸加成至烯酮，不饱和酯，内酯和硝基烯烃。已获得高反应速率和高达89％的ee。

  DOI：

  10.1021/ol027465+

文献信息

• [EN] SYNTHESIS OF R-BIPHENYLALANINOL<br/>[FR] SYNTHÈSE DE R-BIPHÉNYLALANINOL
  申请人：DSM IP ASSETS BV

  公开号：WO2013026773A1

  公开（公告）日：2013-02-28

  This invention relates to a novel process for the synthesis of R-biphenylalaninol and to intermediate compounds that are formed in the process according to the invention, i.e. novel intermediates useful in the synthesis of R-biphenylalaninol. The invention also relates to R-biphenylalaninol, The process according to the invention, the intermediates to of R-biphenylalaninol and of R-biphenylalaninol are all useful in the synthesis of pharmaceutically active compounds.

  本发明涉及一种合成R-双苯丙氨醇的新型工艺，以及在该工艺中形成的中间化合物，即在合成R-双苯丙氨醇过程中有用的新型中间体。本发明还涉及R-双苯丙氨醇、根据本发明的工艺、R-双苯丙氨醇的中间体，以及它们在合成药用活性化合物方面的应用。
• Method of Producing Macrocyclic Ketone, and Intermediate Thereof
  申请人：Matsuda Hiroyuki

  公开号：US20070287870A1

  公开（公告）日：2007-12-13

  A process for producing muscone by methyl addition to the 1,4-conjugation of 2-cyclopentadecenone. By the process, muscone is produced in high yield not under reaction condition including an extremely low temperature and a low concentration but under practical condition. The process comprises subjecting 2-cyclopentadecenone to a 1,4-conjugation addition reaction with an organometallic methylation reagent in the presence of a copper or nickel catalyst and an enol anion scavenger to obtain a 3-methyl-1-cyclopentadecene derivative represented by General Formula (II) and then solvolyzing the enol moiety of the 3-methyl-1-cyclopentadecene derivative to obtain muscone.

  通过对2-环戊十五烯酮的1,4-共轭加成进行甲基化反应制备肉麝香的方法。该过程在实用条件下而非包括极低温度和低浓度的反应条件下高产肉麝香。该过程包括将2-环戊十五烯酮与有机金属甲基试剂在铜或镍催化剂和烯醇阴离子清除剂的存在下进行1,4-共轭加成反应，以获得由通式（II）表示的3-甲基-1-环戊十五烯衍生物，然后溶解3-甲基-1-环戊十五烯衍生物的烯醇基团以获得肉麝香。
• PROCESS FOR THE PREPARATION OF ENANTIOMERICALLY ENRICHED COMPOUNDS
  申请人：DSM IP Assets B.V.

  公开号：EP1506148B1

  公开（公告）日：2008-05-28
• SYNTHESIS OF R-BIPHENYLALANINOL
  申请人：Hermsen Petrus Johannes

  公开号：US20140296559A1

  公开（公告）日：2014-10-02

  This invention relates to a novel process for the synthesis of R-biphenylalaninol and to intermediate compounds that are formed in the process according to the invention, i.e. novel intermediates useful in the synthesis of R-biphenylalaninol. The in vention also relates to R-biphenylalaninol, The process according to the invention, the intermediates to of R-biphenylalaninol and of R-biphenylalaninol are all useful in the synthesis of pharmaceutically active compounds.
• US7479574B2
  申请人：——

  公开号：US7479574B2

  公开（公告）日：2009-01-20