diethyl[pentafluorophenyl(thiophen-2-yl)methyl]amine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: diethyl[pentafluorophenyl(thiophen-2-yl)methyl]amine
• 英文别名: N-ethyl-N-[(2,3,4,5,6-pentafluorophenyl)-thiophen-2-ylmethyl]ethanamine
• 化学式: C₁₅H₁₄F₅NS
• 分子量: 335.341
• InChiKey: BWPUKCAYCQFFNQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  31.5
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  2-噻吩甲醛 、 trifluoro(pentafluorophenyl)silane 、 三甲基硅烷基二乙胺 在 lithium acetate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 2.0h， 以79%的产率得到diethyl[pentafluorophenyl(thiophen-2-yl)methyl]amine
  参考文献：
  名称：

  Pentafluorophenyltrifluorosilane in the silicon Mannich reaction

  摘要：

  The synthesis of alpha-C6F5-substituted amines by a three-component coupling reaction of C6F5SiF3, aromatic aldehydes, and N-trimethylsilylamines has been elaborated. The optimized conditions include performing the reaction in dimethylformamide in the presence of stoichiometric amounts of lithium acetate. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2006.06.164

文献信息

• Pentafluorophenyltrifluorosilane in the silicon Mannich reaction
  作者：Alexander D. Dilman、Vladimir V. Gorokhov、Pavel A. Belyakov、Marina I. Struchkova、Vladimir A. Tartakovsky

  DOI：10.1016/j.tetlet.2006.06.164

  日期：2006.8

  The synthesis of alpha-C6F5-substituted amines by a three-component coupling reaction of C6F5SiF3, aromatic aldehydes, and N-trimethylsilylamines has been elaborated. The optimized conditions include performing the reaction in dimethylformamide in the presence of stoichiometric amounts of lithium acetate. (c) 2006 Elsevier Ltd. All rights reserved.