1,1,1-trifluoro-N-(phenylmethylene)methanesulfonamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1,1,1-trifluoro-N-(phenylmethylene)methanesulfonamide
• 英文别名: N-Benzylidenetrifluoromethanesulfonamide；(NE)-N-benzylidene-1,1,1-trifluoromethanesulfonamide
• 化学式: C₈H₆F₃NO₂S
• 分子量: 237.202
• InChiKey: SSEOGPYUPJJJHO-WUXMJOGZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  54.9
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  1,1,1-trifluoro-N-(phenylmethylene)methanesulfonamide 在 (Me₅-cyclopentadienyl)(4-N-pyrrolidinyl-pyridinyl)Fe⁽²⁺⁾ 作用下， 以 二氯甲烷 、 二甲基亚砜 为溶剂， 反应 12.0h， 生成
  参考文献：
  名称：

  Catalytic Asymmetric Staudinger Reactions to Form β-Lactams:  An Unanticipated Dependence of Diastereoselectivity on the Choice of the Nitrogen Substituent

  摘要：

  There are relatively few methods for the catalytic asymmetric synthesis of beta-lactams, and those that have been reported are generally cis selective. This communication describes the first catalytic enantioselective Staudinger reactions that preferentially furnish trans beta-lactams (trans = relationship of Ph to R1). The key to this method is the use of an N-triflyl protecting group for the imine. Along with serving as interesting targets in their own right, N-triflyl beta-lactams readily react with nucleophiles to generate useful families of compounds, such as gamma-amino alcohols and beta-amino acids.

  DOI：

  10.1021/ja052058p
• 作为产物：
  描述：

  N-sulfinyltrifluoromethanesulfonamide 、 苯甲醛 以 1,2-二氯乙烷 为溶剂， 反应 16.0h， 以77%的产率得到1,1,1-trifluoro-N-(phenylmethylene)methanesulfonamide
  参考文献：
  名称：

  Catalytic Asymmetric Staudinger Reactions to Form β-Lactams:  An Unanticipated Dependence of Diastereoselectivity on the Choice of the Nitrogen Substituent

  摘要：

  There are relatively few methods for the catalytic asymmetric synthesis of beta-lactams, and those that have been reported are generally cis selective. This communication describes the first catalytic enantioselective Staudinger reactions that preferentially furnish trans beta-lactams (trans = relationship of Ph to R1). The key to this method is the use of an N-triflyl protecting group for the imine. Along with serving as interesting targets in their own right, N-triflyl beta-lactams readily react with nucleophiles to generate useful families of compounds, such as gamma-amino alcohols and beta-amino acids.

  DOI：

  10.1021/ja052058p

文献信息

• [EN] BLEACHING COMPOSITIONS CONTAINING IMINE, PEROXIDE COMPOUND AND A TRANSITION METAL CATALYST<br/>[FR] COMPOSITIONS DE BLANCHIMENT CONTENANT DE L'IMINE ET UN COMPOSE PEROXYDE AINSI QU'UN CATALYSEUR A BASE DE METAL DE TRANSITION
  申请人：UNILEVER N.V.

  公开号：WO1996040855A1

  公开（公告）日：1996-12-19

  (EN) A bleach system is described that includes a peroxygen compound which is hydrogen peroxide or an inorganic substance that generates hydrogen peroxide in water, a C1-C30 imine and a transition metal catalyst. Use of the transition metal catalyst promotes the interaction of the hydrogen peroxide and imine thereby enhancing bleach performance.(FR) La présente invention décrit un système de blanchiment comportant un composé peroxyde qui est du peroxyde d'hydrogène ou une substance inorganique qui génère du peroxyde d'hydrogène dans de l'eau, une imine C1-C30 ainsi qu'un catalyseur à base de métal de transition. L'utilisation du catalyseur à base de métal de transition accroît l'interaction du peroxyde d'hydrogène et de l'imine, ce qui a pour conséquence l'amélioration des performances du système de blanchiment.

  该发明描述一种漂白系统，包括过氧化物化合物，其中过氧化物化合物可以是双氧水或无机物，该无机物在水中生成双氧水，C1-C30胺和一种基质过渡金属催化剂。使用基质过渡金属催化剂促进过氧化物与胺的相互作用，从而提升漂白性能。
• YAGUPOLSKIJ L. M.; POPOV V. I.; PAVLENKO N. V.; MALETINA I. I.; MIRONOVA +, ZH. ORGAN. XIMII, 22,(1986) N 10, 2169-2173
  作者：YAGUPOLSKIJ L. M.、 POPOV V. I.、 PAVLENKO N. V.、 MALETINA I. I.、 MIRONOVA +

  DOI：——

  日期：——
• Low-temperature bleaching compositions
  申请人：UNILEVER N.V.

  公开号：EP0446982B1

  公开（公告）日：1994-10-26
• Bleach catalysts and compositions containing same
  申请人：UNILEVER N.V.

  公开号：EP0453003B1

  公开（公告）日：1994-10-05
• BLEACHING COMPOSITIONS CONTAINING IMINE, PEROXIDE COMPOUND AND A TRANSITION METAL CATALYST
  申请人：UNILEVER N.V.

  公开号：EP0775192A1

  公开（公告）日：1997-05-28