8-bromo-12-(4-methylpiperazin-1-yl)-6H-[1]benzothieno[2,3-b][1,5]benzodiazepine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯二氮卓类
• 英文名称: 8-bromo-12-(4-methylpiperazin-1-yl)-6H-[1]benzothieno[2,3-b][1,5]benzodiazepine
• 英文别名: 8-bromo-12-(4-methylpiperazin-1-yl)-6H-[1]benzothiolo[2,3-b][1,5]benzodiazepine
• 化学式: C₂₀H₁₉BrN₄S
• 分子量: 427.368
• InChiKey: JOCOPNUOFDVNPX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  26
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  59.1
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  ethyl 2-(2-amino-5-bromoanilino)benzo[b]thiophene-3-carboxylate 、 N-甲基哌嗪 、 苯甲醚 在 四氯化钛 作用下， 以8-bromo-12-(4-methylpiperazin-1-yl)-6H-[1]benzothieno[2,3-b][1,5]benzodiazepine is obtained的产率得到8-bromo-12-(4-methylpiperazin-1-yl)-6H-[1]benzothieno[2,3-b][1,5]benzodiazepine
  参考文献：
  名称：

  Condensed thiophene compounds and pharmaceutical use thereof

  摘要：

  本发明涉及一种式(I)的缩合噻吩化合物，其中每个符号如规范中所定义，其药学上可接受的盐和水合物。本发明的式(I)化合物可用作一种新型抗精神病药物，对于精神分裂症的阳性症状和阴性症状都有效，且副作用较少，如运动障碍等，并且与严重副作用如粒细胞缺乏症等较少相关。此外，该化合物还可用作阿尔茨海默病和躁郁症的治疗剂。

  公开号：

  US20020042411A1

文献信息

• Fused thiophene compounds and medicinal use thereof
  申请人：Welfide Corporation

  公开号：US06271225B1

  公开（公告）日：2001-08-07

  A condensed thiophene compound of the formula (I) wherein each symbol is as defined in the specification, a pharmaceutically acceptable salt thereof and hydrates thereof. The compound of the formula (I) of the present invention is useful as a novel antipsychotic agent which is effective for both positive symptoms and negative symptoms of schizophrenia, which is associated with less side effects such as extrapyramidal motor disorder and the like and which is less associated with serious side effects such as agranulocytosis and the like. In addition, this compound is also useful as a therapeutic agent of Alzheimer's disease and manic-depressive illness.

  公式（I）的浓缩噻吩化合物，其中每个符号如规范中所定义，其药用盐和水合物。本发明的公式（I）化合物作为一种新型抗精神病药物非常有用，对于精神分裂症的正性症状和负性症状都有效，且副作用较小，如运动障碍等，并且与严重的副作用，如粒细胞缺乏症等相关性较小。此外，该化合物还可用作阿尔茨海默病和躁郁症的治疗药物。
• FUSED THIOPHENE COMPOUNDS AND MEDICINAL USE THEREOF
  申请人：YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD.

  公开号：EP1016664A1

  公开（公告）日：2000-07-05

  A condensed thiophene compound of the formula (I) wherein each symbol is as defined in the specification, a pharmaceutically acceptable salt thereof and hydrates thereof. The compound of the formula (I) of the present invention is useful as a novel antipsychotic agent which is effective for both positive symptoms and negative symptoms of schizophrenia, which is associated with less side effects such as extrapyramidal motor disorder and the like and which is less associated with serious side effects such as agranulocytosis and the like. In addition, this compound is also useful as a therapeutic agent of Alzheimer's disease and manic-depressive illness.

  式 (I) 的缩合噻吩化合物 其中各符号如说明书中所定义，其药学上可接受的盐及其水合物。本发明的式(I)化合物可作为一种新型抗精神病药物，对精神分裂症的阳性症状和阴性症状均有效，副作用较少，如锥体外系运动障碍等，严重副作用较少，如粒细胞减少等。此外，该化合物还可用作阿尔茨海默病和躁狂抑郁症的治疗剂。
• US6271225B1
  申请人：——

  公开号：US6271225B1

  公开（公告）日：2001-08-07
• US6455521B1
  申请人：——

  公开号：US6455521B1

  公开（公告）日：2002-09-24
• Condensed thiophene compounds and pharmaceutical use thereof
  申请人：——

  公开号：US20020042411A1

  公开（公告）日：2002-04-11

  A condensed thiophene compound of the formula (I) 1 wherein each symbol is as defined in the specification, a pharmaceutically acceptable salt thereof and hydrates thereof. The compound of the formula (I) of the present invention is useful as a novel antipsychotic agent which is effective for both positive symptoms and negative symptoms of schizophrenia, which is associated with less side effects such as extrapyramidal motor disorder and the like and which is less associated with serious side effects such as agranulocytosis and the like. In addition, this compound is also useful as a therapeutic agent of Alzheimer's disease and manic-depressive illness.

  本发明涉及一种式(I)的缩合噻吩化合物，其中每个符号如规范中所定义，其药学上可接受的盐和水合物。本发明的式(I)化合物可用作一种新型抗精神病药物，对于精神分裂症的阳性症状和阴性症状都有效，且副作用较少，如运动障碍等，并且与严重副作用如粒细胞缺乏症等较少相关。此外，该化合物还可用作阿尔茨海默病和躁郁症的治疗剂。