3-((perfluorobutyl)thio)propanoic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 3-((perfluorobutyl)thio)propanoic acid
• 化学式: C₇H₅F₉O₂S
• 分子量: 324.167
• InChiKey: IQQPNYLCZFGRPF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.62
• 重原子数：
  19.0
• 可旋转键数：
  6.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  37.3
• 氢给体数：
  1.0
• 氢受体数：
  2.0

反应信息

• 作为产物：
  描述：

  sodium perfluorobutylsulfinate 、 3-巯基丙酸 在 dipotassium peroxodisulfate 、 silver nitrate 作用下， 以 水 、 乙腈 为溶剂， 反应 24.0h， 以87%的产率得到3-((perfluorobutyl)thio)propanoic acid
  参考文献：
  名称：

  Silver-catalyzed fluoroalkylation of thiols using fluoroalkanesulfinates

  摘要：

  A practical sliver-catalyzed fluoroalkylation of aryl-, heteroaryl- and allcylthiols has been developed. The reaction has a good functional-group tolerance and excellent selectivity. A variety of stable and solid fluoroalkanesulfinates including di- and perfluoroalkanesulfinates can be employed. This methodology provides a straightforward and streamlined access to perfluoroallcylthiolated organic molecules.[GRAPHICS](C) 2016 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jfluchem.2016.11.010

文献信息

• Silver-catalyzed fluoroalkylation of thiols using fluoroalkanesulfinates
  作者：Jing-jing Ma、Qi-ran Liu、Guo-ping Lu、Wen-bin Yi

  DOI：10.1016/j.jfluchem.2016.11.010

  日期：2017.1

  A practical sliver-catalyzed fluoroalkylation of aryl-, heteroaryl- and allcylthiols has been developed. The reaction has a good functional-group tolerance and excellent selectivity. A variety of stable and solid fluoroalkanesulfinates including di- and perfluoroalkanesulfinates can be employed. This methodology provides a straightforward and streamlined access to perfluoroallcylthiolated organic molecules.[GRAPHICS](C) 2016 Elsevier B.V. All rights reserved.