(3-(oxiran-2-ylmethoxy)phenyl)methanol

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: (3-(oxiran-2-ylmethoxy)phenyl)methanol
• 英文别名: 3-glycidyloxybenzyl alcohol；[3-(oxiran-2-ylmethoxy)phenyl]methanol
• 化学式: C₁₀H₁₂O₃
• 分子量: 180.203
• InChiKey: WOFJRZLKWHCFCL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  42
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (3-(oxiran-2-ylmethoxy)phenyl)methanol 、 1-(5-methyl-6-phenylthieno[2,3-d]pyrimidin-4-yl)piperidin-4-amine 以 iPrOH DMSO 为溶剂， 反应 35.0h， 以to give the title compound with 36% yield的产率得到1-(3-(hydroxymethyl)phenoxy)-3-(1-(5-methyl-6-phenylthieno[2,3-d]pyrimidin-4-yl)piperidin-4-ylamino)propan-2-ol
  参考文献：
  名称：

  ARYLOXYPROPANOLAMINES, METHODS OF PREPARATION THEROF AND USE OF ARYLOXYPROPANOLAMINES AS MEDICAMENTS

  摘要：

  本发明涉及新型芳氧基丙醇胺。该发明还涉及含有所述化合物的药学上可接受的盐和溶剂化合物，其制备方法以及相应的合成中间体。所述化合物在β3肾上腺素能受体上具有激动活性，并且可用于治疗受β3肾上腺素能受体激活影响的疾病。

  公开号：

  US20080249114A1
• 作为产物：
  描述：

  3-羟基苯甲醇 、 环氧溴丙烷 在 potassium carbonate 作用下， 以 丁酮 为溶剂， 生成 (3-(oxiran-2-ylmethoxy)phenyl)methanol
  参考文献：
  名称：

  A vHTS approach for the identification of β-adrenoceptor ligands

  摘要：

  Using a vHTS based on a pharmacophore alignment on known beta 3-adrenoceptor ligands, a set of intriguing beta-adrenoceptor ligands was identified, optimization of which resulted in a selective and potent human beta 2-AR antagonist. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.04.009

文献信息

• Epoxy resins consisting of flexible chains terminated with
  申请人：National Starch & Chemical Investment Holding Corp.

  公开号：US05717054A1

  公开（公告）日：1998-02-10

  This invention relates to flexible epoxy resins that have a structural composition comprising an oligomeric backbone of alkylene or alkyleneoxy repeat units, terminated with an aromatic moiety bearing one or more epoxy functionalities.

  这项发明涉及具有结构组成的柔性环氧树脂，其包括具有烷基或烷氧基重复单元的寡聚体骨架，末端带有一个或多个环氧功能团的芳香基团。
• Aryloxypropanolamines, methods of preparation thereof and use of aryloxypropanolamines as medicaments
  申请人：4SC AG

  公开号：EP1947103A1

  公开（公告）日：2008-07-23

  This invention relates to novel aryloxypropanolamines. The invention also relates to the pharmaceutically acceptable salts and solvates containing said compounds, methods for the preparation thereof and to respective synthesis intermediates. Said compounds have agonistic activity at β3 adrenergic receptors and are useful for treatment of ailments influenced by activation of β3 adrenergic receptors.

  本发明涉及新型芳氧基丙醇胺。该发明还涉及含有所述化合物的药学上可接受的盐和溶剂化物，其制备方法以及相应的合成中间体。所述化合物在β3肾上腺素能受体上具有激动作用，并且可用于治疗受到β3肾上腺素能受体激活影响的疾病。
• SILANE/UREA COMPOUND AS A HEAT-ACTIVATABLE CURING AGENT FOR EPOXIDE RESIN COMPOSITIONS
  申请人：Kramer Andreas

  公开号：US20110155320A1

  公开（公告）日：2011-06-30

  Silanes of formula (I), or of substrates whose surface is coated or derivatized with a silane of formula (I), as a curing agent for epoxy resins which is activatable at elevated temperature. Such thermosetting epoxy resin compositions allow a large reduction in the curing temperature without great impairment of their storage stability.

  公式（I）的硅烷，或表面涂有或衍生出公式（I）的硅烷的底物，可作为热活化的环氧树脂固化剂。这种热固性环氧树脂组合物可以在不大幅度损害其储存稳定性的情况下大幅降低固化温度。
• HEAT-CURING EPOXY RESIN COMPOSITION COMPRISING AN ACCELERATOR HAVING HETEROATOMS
  申请人：Kramer Andreas

  公开号：US20110067813A1

  公开（公告）日：2011-03-24

  A heat-curing epoxy resin composition that includes an epoxy resin, a curing agent, an accelerator, and an optional toughener. The epoxy resin compositions are suitable in particular for use as bodyshell adhesives and for preparation of structural foams. An accelerator of formula (I) results in increased impact strength the of heat-curing epoxy resin compositions.

  一种热固性环氧树脂组合物，包括环氧树脂、固化剂、促进剂和可选增韧剂。该环氧树脂组合物特别适用于用作车身胶粘剂和制备结构泡沫。式（I）的促进剂可增强热固性环氧树脂组合物的抗冲击强度。
• Aryloxypropanolamines, methods of preparation therof and use of aryloxypropanolamines as medicaments
  申请人：4SC AG

  公开号：US08207174B2

  公开（公告）日：2012-06-26

  This invention relates to novel aryloxypropanolamines. The invention also relates to the pharmaceutically acceptable salts and solvates containing said compounds, methods for the preparation thereof and to respective synthetic intermediates. Said compounds have agonistic activity at β3 adrenergic receptors and are useful for treatment of ailments influenced by activation of β3 adrenergic receptors.

  本发明涉及新颖的芳氧基丙醇胺。本发明还涉及含有该化合物的药学上可接受的盐和溶剂、其制备方法及相应的合成中间体。该化合物在β3肾上腺素能受体上具有激动作用，可用于治疗受β3肾上腺素能受体激活影响的疾病。