N-(1-phenyl-1-(2-hydroxyphenyl)methyl)morpholine

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(1-phenyl-1-(2-hydroxyphenyl)methyl)morpholine
• 英文别名: N-(2-hydroxyphenyl-(phenyl)methyl)morpholine；2-[morpholin-4-yl(phenyl)methyl]phenol；2-[(4-morpholinyl)phenylmethyl]phenol；2-(morpholino(phenyl)methyl)phenol；2-[morpholino(phenyl)methyl]phenol
• 化学式: C₁₇H₁₉NO₂
• 分子量: 269.343
• InChiKey: GWSZQRCZPKHXGV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  20
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  32.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  苯胺 在 盐酸 、 sodium nitrite 作用下， 以 水 为溶剂， 反应 14.58h， 生成 N-(1-phenyl-1-(2-hydroxyphenyl)methyl)morpholine
  参考文献：
  名称：

  Sequential One-Pot Access to Molecular Diversity through Aniline Aqueous Borylation

  摘要：

  On the basis of our recently reported aniline aqueous borylation, molecular diversity was achieved in a one-pot process by combining other reactions such as esterification, Suzuki-Miyaura coupling, hydrogenolysis, or Petasis borono-Mannich.

  DOI：

  10.1021/jo501665e

文献信息

• Magnetically Retrievable Nanocomposite Based on Thiosemicarbazide–Formaldehyde Resin as a Versatile Nucleophilic Scavenger
  作者：Maomin Zhen、Danfeng Zhang、Zeyu Zhang、Yanqing Peng

  DOI：10.1021/acscombsci.6b00090

  日期：2016.12.12

  retrievable nanocomposite was prepared by in situ polycondensation and entrapment of iron oxide nanoparticles. This material was found to be efficient in trapping excess electrophilic reagents such as carbonyl compounds, acid chlorides and isothiocyanates. Advantages of the new scavenger include facile preparation, high loading capacity, low cost, satisfactory swelling properties in polar solvents, and

  通过原位缩聚和包埋氧化铁纳米颗粒制备了可磁性回收的纳米复合材料。发现该材料可有效捕集过量的亲电试剂，例如羰基化合物，酰氯和异硫氰酸酯。新型清除剂的优点包括制备简便，装载量高，成本低，在极性溶剂中具有令人满意的溶胀性能以及方便的磁回收。
• 2<i>H</i>-Chromenes from Salicylaldehydes by a Catalytic Petasis Reaction
  作者：Qian Wang、M. G. Finn

  DOI：10.1021/ol006710r

  日期：2000.12.1

  The Petasis condensation of vinylic or aromatic boronic acids, aromatic aldehydes, and amines is assisted by a hydroxy group adjacent to the aldehyde moiety. The products derived from salicylaldehydes and vinylboronic acids undergo cyclization to 2H-chromene compounds with ejection of amine upon heating. A catalytic preparation of 2H-chromenes using resin-bound amine is reported, allowing the convenient

  乙烯基或芳族硼酸，芳族醛和胺的Petasis缩合反应是通过与醛部分相邻的羟基进行的。衍生自水杨醛和乙烯基硼酸的产物在加热时经过胺的喷射而环化成2H-色烯化合物。据报道，使用树脂结合的胺催化制备2H-色烯，可以方便地掺入各种组分。
• Tetranuclear Zn₂Ln₂ coordination clusters as catalysts in the Petasis borono-Mannich multicomponent reaction
  作者：Prashant Kumar、Kieran Griffiths、Smaragda Lymperopoulou、George E. Kostakis

  DOI：10.1039/c6ra17209a

  日期：——

  We report herein for the first time the efficiency of heteronuclear Zn/Ln coordination clusters (CCs) as catalysts for the multicomponent Mannich-type condensation that involves amines, aldehydes and boronic acids, known...

  我们在此首次报道异核Zn / Ln配位簇（CC）作为涉及胺，醛和硼酸的多组分曼尼希型缩合反应的催化剂的效率，这是已知的...
• Three-component, solvent-free synthesis of Betti base catalyzed by sulfated polyborate
  作者：Manisha S. Patil、Chetan K. Khatri、Ganesh U. Chaturbhuj

  DOI：10.1007/s00706-018-2169-z

  日期：2018.8

  this work, efficient, mild, and eco-friendly procedure of 1-aminoalkyl-2-phenol/Betti base from one-pot three-component condensations of aldehyde, phenol, and morpholine in the presence of sulfated polyborate catalyst, under a solvent-free condition at 100 °C, is described. The key advantages of the present method are short reaction time, high yields, aqueous work-up procedure, low cost, stable, reusable

  摘要在这项工作中，在溶剂化硫酸多硼酸盐催化剂存在下，由一锅三元乙醛，苯酚和吗啉的缩合反应制得的1-氨基烷基-2-苯酚/贝蒂碱的高效，温和和环保的方法描述了100°C时的无条件状态。本方法的主要优点是反应时间短，产率高，水后处理程序，成本低，稳定，可重复使用的催化剂和无溶剂的反应条件。 图形概要
• Microwave-assisted nanocatalysis: A CuO NPs/rGO composite as an efficient and recyclable catalyst for the Petasis-borono–Mannich reaction
  作者：Anshu Dandia、Sarika Bansal、Ruchi Sharma、Kuldeep S. Rathore、Vijay Parewa

  DOI：10.1039/c8ra05203d

  日期：——

  CuO NPs/rGO composite was synthesized and characterized by various analytical techniques an used as a recyclable catalyst for Petasis-borono–Mannich reaction under microwave irradiation.

  CuO NPs/rGO复合材料通过各种分析技术合成和表征，并作为可回收催化剂应用于微波辐射下的Petasis-硼酸曼尼希反应。