他骨化醇一水物 | 93129-94-3

• 物质功能分类: 生物化工 - 生化试剂 - 激动剂抑制剂
• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 中文名称: 他骨化醇一水物
• 中文别名: 他卡西妥一水物
• 英文名称: Tacalcitol monohydrate
• 英文别名: (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(2R,5R)-5-hydroxy-6-methylheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol;hydrate
• CAS: 93129-94-3
• 化学式: C27H46O4
• 分子量: 434.7
• InChiKey: UCLYOJXQGOXQKJ-XXBHHXRKSA-N

物化性质

• 溶解度：
  溶于二甲基亚砜

计算性质

• 辛醇/水分配系数(LogP)：
  4.74
• 重原子数：
  31
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  61.7
• 氢给体数：
  4
• 氢受体数：
  4

制备方法与用途

生物活性方面，Tacalcitol一水合物能够通过调节钙离子的水平来促进骨骼发育。

文献信息

• Specific time-delayed burst profile delivery system
  申请人：Dexcel Pharma Technologies Ltd.

  公开号：EP1731142A1

  公开（公告）日：2006-12-13

  The invention provides a delivery device for the delayed release of an active agent in the gastrointestinal tract comprising a core, comprising an active agent; a first outer coating, comprising a relatively hydrophobic substantially water insoluble polymer having substantially water insoluble hydrophilic particles embedded therein; and a first inner coating layer, comprising an agent that can cause the dissolution of at least one of the water insoluble components of the outer coating, and optionally a water soluble polymer, such that the insoluble particles in the outer coating, upon absorption of liquid, form channels leading to the inner coating layer, thus enabling the dissolution thereof, whereby the agents contained therein are released to cause the dissolution and/or degradation (destruction) of the outer coating, and the release of the pharmaceutically acceptable active agent from the core of the device.

  本发明提供了一种用于在胃肠道中延迟释放活性剂的给药装置，该装置包括一个内核，内核中含有活性剂；一个第一外涂层，外涂层中含有相对疏水的基本上不溶于水的聚合物，聚合物中嵌入了基本上不溶于水的亲水颗粒；第一内涂层层，包括可导致外涂层中至少一种水不溶成分溶解的药剂，以及可选的水溶性聚合物，从而使外涂层中的不溶性颗粒在吸收液体后形成通向内涂层层的通道，从而使其溶解，其中所含的药剂由此释放出来，导致外涂层溶解和/或降解（破坏），并从装置核心释放出药学上可接受的活性剂。
• COMBINATION THERAPY COMPRISING A POLYUNSATURATED KETONE AND A SECOSTEROID
  申请人：Avexxin AS

  公开号：EP3463471A1

  公开（公告）日：2019-04-10
• COMBINATION THERAPY COMPRISING A THIAZOLE AND A SECOSTEROID TO TREAT SKIN CONDITIONS
  申请人：Avexxin AS

  公开号：EP3534956A1

  公开（公告）日：2019-09-11
• SPECIFIC TIME-DELAYED BURST PROFILE DELIVERY SYSTEM
  申请人：PENHASI Adel

  公开号：US20110287094A1

  公开（公告）日：2011-11-24

  The invention provides a delivery device for the delayed release of an active agent in the gastrointestinal tract comprising a core, comprising an active agent; a first outer coating, comprising a relatively hydrophobic substantially water insoluble polymer having substantially water insoluble hydrophilic particles embedded therein; and a first inner coating layer, comprising an agent that can cause the dissolution of at least one of the water insoluble components of the outer coating, and optionally a water soluble polymer, such that the insoluble particles in the outer coating, upon absorption of liquid, form channels leading to the inner coating layer, thus enabling the dissolution thereof, whereby the agents contained therein are released to cause the dissolution and/or degradation (destruction) of the outer coating, and the release of the pharmaceutically acceptable active agent from the core of the device.
• CALCIUM SILICATE-CONTAINING ACRYLIC ADHESIVE PATCH
  申请人：Hisamitsu Pharmaceutical Co., Inc.

  公开号：US20200405654A1

  公开（公告）日：2020-12-31

  A problem addressed by the present invention is to provide an adhesive patch, which contains an acrylic adhesive base material, is easy to handle, prevents cold flow independently of physical properties and concentrations while being kept in a packaging material or being adhered, and during storage, keeps the drug in the adhesive patch stable and maintains the suitable administration form of the drug over a long period so that the drug can provide sufficient medicinal effect for a long time. The present invention relates to an adhesive patch provided with a backing layer and an adhesive agent layer, the adhesive agent layer containing a drug, an acrylic adhesive base material, and calcium silicate. The present invention also relates to a method for producing the adhesive patch.