lauroyl ethyl arginate hydrochloride

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: lauroyl ethyl arginate hydrochloride
• 英文别名: ethyl lauroyl arginine hydrochloride；ethyl lauroyl arginine HCL；(2S)-5-(diaminomethylideneamino)-2-[dodecanoyl(ethyl)amino]pentanoic acid;hydrochloride
• 化学式: C₂₀H₄₀N₄O₃*ClH
• 分子量: 421.024
• InChiKey: DKTWBTDSEQGNFQ-LMOVPXPDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.68
• 重原子数：
  28
• 可旋转键数：
  17
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  122
• 氢给体数：
  4
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  月桂酰氯 、 L-arginine ethyl ester dihydrochloride 在 三乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 0.5h， 以94.06%的产率得到lauroyl ethyl arginate hydrochloride
  参考文献：
  名称：

  PROCESS FOR THE SYNTHESIS OF HIGHLY PURE CATIONIC SURFACTANT PRODUCTS

  摘要：

  本发明涉及通过消除或减少先前技术中困扰的杂质生成，合成高纯度阳离子表面活性剂产品。这是通过在非水解或近乎非水解反应条件下，使用脂肪酸卤化物（C4到C20）与氨基酸酯及其无机盐或有机盐（例如氨基酸或氨基酸的盐酸或硫酸盐或醋酸盐等）进行单相或两相反应体系的N-酰化反应，得到高纯度的N-酰基取代氨基酸酯，特别是乙基月桂酰精氨酸酯。本工艺通过过程策略而非测量和控制步骤实现pH控制。这种室温工艺在一定温度变化范围内稳定，消除了严格的低温控制。

  公开号：

  US20140323756A1

文献信息

• PROCESS FOR THE SYNTHESIS OF HYDROCHLORIDE SALT OF N-FATTY ACYLSUBSTITUTED AMINO ACID ETHYL ESTERS
  申请人：Ghare Vishwas Sadhu

  公开号：US20110077423A1

  公开（公告）日：2011-03-31

  The present invention relates to a process for preparing hydrochloride salt of N-fatty acyl substituted amino acid ethyl ester. Said process includes the steps of: dissolving L-arginine ethyl ester dihydrochloride in distilled water with continuous agitation for a period of about 10 to about 20 minutes to obtain a clear solution; lowering the temperature of the clear solution to about 5° C. to about 10° C. to obtain a cooled solution; adjusting the pH of the cooled solution in the range of about 7 to about 8 by adding sodium hydroxide solution; adding at least one organic solvent to the clear solution with continuous agitation to obtain an intermediate mixture; condensing the intermediate mixture by simultaneously adding an acid halide and 20% sodium hydroxide solution at a temperature of about 7° C. to about 9° C. and at a pH in the range of about 7.2 to about 7.5 for about 2 hours to obtain a mixture; raising the temperature of the mixture to about 18 to about 20° C. followed by addition of sodium hydroxide to adjust the pH of the mixture to about 7.3; warming the mixture at a temperature of about 25 to about 30° C. to obtain a resultant mixture containing organic phase and aqueous phase; separating the organic phase and aqueous phase of the resultant mixture by settling the mixture; and distilling the organic phase under vacuum at a temperature of about 70° C. to about 75° C. to obtain a hydrochloride salt of ethyl lauroyl arginate.

  本发明涉及一种制备N-脂肪酰基取代氨基酸乙酯盐酸盐的过程。该过程包括以下步骤：将L-精氨酸乙酯二盐酸盐在蒸馏水中连续搅拌约10至20分钟以获得清澈的溶液；将清澈的溶液降温至约5°C至10°C以获得冷却的溶液；通过加入氢氧化钠溶液将冷却的溶液的pH值调节在约7至8的范围内；在连续搅拌的情况下向清澈的溶液中加入至少一种有机溶剂以获得中间混合物；同时在温度约为7°C至9°C，pH值在约7.2至7.5的条件下，通过同时加入酸卤和20％氢氧化钠溶液来缩合中间混合物，反应约2小时以获得混合物；将混合物的温度升高至约18至20°C，然后加入氢氧化钠以将混合物的pH值调节至约7.3；在温度约为25°C至30°C的条件下加热混合物以获得含有有机相和水相的结果混合物；通过沉淀混合物来分离结果混合物的有机相和水相；并在约70°C至75°C的温度下在真空下蒸馏有机相以获得月桂酰乙基精氨酸盐酸盐。
• PROCESS FOR SYNTHESIS OF CATIONIC SURFACTANTS
  申请人：Sadhu Ghare Vishwas

  公开号：US20100152480A1

  公开（公告）日：2010-06-17

  The present invention relates to the methods of synthesizing hydrochloride salt of N-fatty acyl substituted amino acid ethyl ester which comprises a) condensation of aqueous solution of esterified amino acid with an acid halide to obtain an intermediate suspension and b) isolating a hydrochloride salt of N-fatty acylsubstituted amino acid ethyl ester from the intermediate suspension.

  本发明涉及合成N-脂肪酰取代氨基酸乙酯盐的方法，包括a)将酯化氨基酸的水溶液与酸卤缩合，得到中间悬浮液，b)从中间悬浮液中分离出N-脂肪酰取代氨基酸乙酯的盐酸盐。
• RELOADABLE FINISHES FOR TEXTILES AND FORMULATIONS FOR LOADING SUCH FINISHES
  申请人：Gaupp Theo

  公开号：US20130102943A1

  公开（公告）日：2013-04-25

  A polymer compound according to the invention comprises an acrylic acid copolymer composed of acrylic acid derivatives and/or methacrylic acid derivatives, containing: a) at least one acrylic acid derivative and/or methacrylic acid derivative substituted with a sulfonic acid group; b) at least one hydrophilically substituted acrylic acid derivative and/or methacrylic acid derivative; c) at least one lipophilically substituted acrylic acid derivative and/or methacrylic acid derivative; and d) at least one acrylic acid derivative and/or methacrylic acid derivative which acts as a crosslinking agent. In the method according to the invention for loading textile products with a low-molecular compound, a) a textile product is provided with a finishing layer whose accessible surface has a negative charge; and b) the textile product is brought together with an emulsion or active substance solution, for example by immersing the textile product in the emulsion/solution, or by spraying the emulsion/solution on the textile product. At least one low-molecular compound is contained in the dispersed phase of the emulsion, and the surface of the particles of the dispersed phase has a positive charge.

  本发明的聚合物化合物包括丙烯酸衍生物和/或甲基丙烯酸衍生物组成的丙烯酸共聚物，其中包含：a) 至少一种丙烯酸衍生物和/或甲基丙烯酸衍生物，其被磺酸基取代; b) 至少一种亲水性取代的丙烯酸衍生物和/或甲基丙烯酸衍生物; c) 至少一种亲脂性取代的丙烯酸衍生物和/或甲基丙烯酸衍生物; 和d) 至少一种作为交联剂的丙烯酸衍生物和/或甲基丙烯酸衍生物。根据本发明用于将纺织品产品装载低分子化合物的方法，a) 提供具有负电荷的表面可接触的整理层的纺织品产品; 和b) 将纺织品产品与乳液或活性物质溶液接触，例如通过将纺织品浸入乳液/溶液中或将乳液/溶液喷洒到纺织品上。乳液的分散相中含有至少一种低分子化合物，且分散相的粒子表面具有正电荷。
• Antiplaque breath freshening consumable film
  申请人：——

  公开号：US20040258630A1

  公开（公告）日：2004-12-23

  An orally consumable film composition for delivering antiplaque and breath freshening benefits to the oral cavity which is rapidly dissolvable or dispersible in the oral cavity, the composition being comprised of a homogeneous mixture of a water soluble or dispersible film forming polymer and an antibacterial ester having the formula 1 where R 1 is an alkyl chain of 1 to 8 carbon atoms, and R 2 is an alkyl chain of 6 to 30 carbon atoms and X is an anion.

  一种口腔可口服薄膜组合物，用于向口腔提供抗菌斑和口气清新的效益，该组合物在口腔内迅速溶解或分散，该组合物由水溶性或可分散的薄膜形成聚合物和具有以下公式的抗菌酯物的均匀混合物组成：1其中R1是1到8个碳原子的烷基链，R2是6到30个碳原子的烷基链，X是阴离子。
• Antiplaque oral care compositions
  申请人：Boyd J. Thomas

  公开号：US20060193791A1

  公开（公告）日：2006-08-31

  The invention provides oral compositions including a safe and effective amount of a compound represented by the formula (I): wherein R 1 and R 2 are independently selected from a hydrogen atom and an alkyl group and X − is an anion, and n is an integer of 1 to 25; and (b) a surfactant.

  本发明提供了口腔组合物，其中包括化合物(I)的安全有效量，该化合物的化学式如下： 其中R1和R2独立地选择自氢原子和烷基，X-是阴离子，n是1到25的整数；以及(b)表面活性剂。