4-[(2,2-dimethylpropyl)oxy]-2-[(phenylmethyl)oxy]benzene

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 4-[(2,2-dimethylpropyl)oxy]-2-[(phenylmethyl)oxy]benzene
• 英文别名: 1-(2,2-Dimethylpropoxy)-2-phenylmethoxybenzene
• 化学式: C₁₈H₂₂O₂
• 分子量: 270.371
• InChiKey: WDQIIJMPSUOGLD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  20
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  1,2-二氟苯 在 N,N-二甲基丙烯基脲 、 potassium tert-butylate 作用下， 以 甲苯 为溶剂， 反应 32.0h， 生成 4-[(2,2-dimethylpropyl)oxy]-2-[(phenylmethyl)oxy]benzene
  参考文献：
  名称：

  Novel Synthesis of Desymmetrized Resorcinol Derivatives:  Aryl Fluoride Displacement on Deactivated Substrates

  摘要：

  A short, high-yielding synthesis of differentially substituted resorcinol derivatives has been developed that utilizes 1,3difluorobenzene as the starting material and employs sequential nucleophilic aromatic substitution (SNAr) reactions to generate desymmetrized products. The scope and limitations of the second SNAr reaction on the deactivated 1-alkoxy-3-fluorobenzene intermediates have been investigated. This methodology has also been employed in the synthesis of desymmetrized catechol derivatives from 1,2difluorobenzene.

  DOI：

  10.1021/jo0523868

文献信息

• 10A-AZALIDE COMPOUND CROSSLINKED AT 10A- AND 12-POSITIONS
  申请人：Sugimoto Tomohiro

  公开号：US20110237784A1

  公开（公告）日：2011-09-29

  A novel 10a-azalide compound crosslinked at the 10a- and 12-positions, which is represented by the following formula, and is effective on even Hemophilus influenzae , or erythromycin resistant bacteria (e.g., resistant pneumococci and streptococci).

  一种新型的10a-azalide化合物，其在10a-和12-位置交联，化学式如下，并且对于Hemophilus influenzae，或者对红霉素产生耐药性的细菌（例如耐药性肺炎球菌和链球菌）具有有效性。
• US8293715B2
  申请人：——

  公开号：US8293715B2

  公开（公告）日：2012-10-23
• Novel Synthesis of Desymmetrized Resorcinol Derivatives:  Aryl Fluoride Displacement on Deactivated Substrates
  作者：Aujin Kim、Jeremiah D. Powers、Jennifer F. Toczko

  DOI：10.1021/jo0523868

  日期：2006.3.1

  A short, high-yielding synthesis of differentially substituted resorcinol derivatives has been developed that utilizes 1,3difluorobenzene as the starting material and employs sequential nucleophilic aromatic substitution (SNAr) reactions to generate desymmetrized products. The scope and limitations of the second SNAr reaction on the deactivated 1-alkoxy-3-fluorobenzene intermediates have been investigated. This methodology has also been employed in the synthesis of desymmetrized catechol derivatives from 1,2difluorobenzene.