4-methyl-1-phenyl-hexan-1-ol

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 4-methyl-1-phenyl-hexan-1-ol
• 英文别名: 4-methyl-1-phenylhexan-1-ol
• 化学式: C₁₃H₂₀O
• 分子量: 192.301
• InChiKey: RFNWDQBMIOBMGJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2-甲基丁醇 、 苯乙酮 在 tris(triphenylphosphine)ruthenium(II) chloride 氢氧化钾 作用下， 以 1,4-二氧六环 为溶剂， 反应 40.0h， 以81%的产率得到4-methyl-1-phenyl-hexan-1-ol
  参考文献：
  名称：

  An Unusual Type of Ruthenium-Catalyzed Transfer Hydrogenation of Ketones with Alcohols Accompanied by C−C Coupling

  摘要：

  DOI：

  10.1021/jo0108459

文献信息

• Diamine-Free Lithiation−Trapping of <i>N</i>-Boc Heterocycles using <i>s</i>-BuLi in THF
  作者：Graeme Barker、Peter O’Brien、Kevin R. Campos

  DOI：10.1021/ol1017799

  日期：2010.9.17

  A diamine-free protocol for the s-BuLi-mediated lithiation-trapping of N-Boc heterocycles has been developed. In the optimized procedure, lithiation is accomplished using s-BuLi in THF at 30 degrees C for only 5 or 10 min. Subsequent electrophilic trapping or transmetalation-Negishi coupling delivered a range of functionalized pyrrolidines, imidazolidines, and piperazines in 43-83% yield.
• Direct β-Alkylation of Secondary Alcohols with Primary Alcohols Catalyzed by a Cp*Ir Complex
  作者：Ken-ichi Fujita、Chiho Asai、Tetsuhiro Yamaguchi、Fumihiro Hanasaka、Ryohei Yamaguchi

  DOI：10.1021/ol051517o

  日期：2005.9.1

  A new catalytic system for beta-alkylation of secondary alcohols has been developed. In the presence of [Cp*IrCl2](2) (CP* = pentamethylcyclopentadienyl) catalyst and base, the reactions of various secondary alcohols with primary alcohols give beta-alkylated higher alcohols in good to excellent yields without any hydrogen acceptor or hydrogen donor. This reaction proceeds via successive hydrogen-transfer reactions and aldol condensation.