Cobalt-catalyzed multisubstituted allylation of the chelation-assisted C–H bond of (hetero)arenes with cyclopropenes
作者:Kuppan Ramachandran、Pazhamalai Anbarasan
DOI:10.1039/d1sc03476f
日期:——
Cp*CoIII-catalyzed ring-opening isomerization of cyclopropenes to cobalt vinylcarbene has been utilized for the synthesis of multisubstituted allylarenes via directing group-assisted functionalization of C–H bonds of arenes and heteroarenes.
Rh(III)-Catalyzed Oxidative C–2 Coupling of <i>N</i>-Pyridinylindoles with Benzo[<i>b</i>]thiophene 1,1-Dioxides via C–H Bond Activation
作者:Subramani Kumaran、Kanniyappan Parthasarathy
DOI:10.1021/acs.joc.1c00301
日期:2021.6.18
An efficient Rh(III)-catalyzedcross-dehydrogenativecoupling of N-pyridinylindoles with benzo[b]thiophene 1,1-dioxides has been developed through directing-group-assisted C–H activation. This transformation constructs a new C–C bond from two inert C–H bonds in a one-pot reaction. The present reaction is compatible with various functional groups with respect to indoles and benzothiophene[b] 1,1-dioxides
已经通过导向基团辅助的 C-H 活化开发了一种高效的 Rh(III) 催化的N-吡啶基吲哚与苯并 [ b ] 噻吩 1,1-二氧化物的交叉脱氢偶联。这种转化在一锅反应中由两个惰性 C-H 键构建了一个新的 C-C 键。本反应与关于吲哚和苯并噻吩[ b ] 1,1-二氧化物的各种官能团相容。此外,还探索了合成化合物的发射特性。
NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF
申请人:Yokotani Junichi
公开号:US20090240052A1
公开(公告)日:2009-09-24
An anthranilic acid derivative represented by the general formula (X) [wherein R
1
represents hydrogen or a carboxy-protecting group; R
2
represents optionally substituted phenyl, a heterocyclic group, etc.; R
3
represents optionally substituted phenyl, a monocyclic heterocyclic group, etc.; X
1
represents carbonyl, etc.; X
2
represents optionally substituted alkylene group, a bond, etc.; X
3
represents oxygen, a bond, etc.; and X
4
represents a group represented by the general formula -X
5
-X
6
- or -X
6
-X
5
- (wherein X
5
means oxygen, a bond, etc.; and X
6
means optionally substituted alkylene, a bond, etc.)] or a salt of the derivative. The derivative or salt has the inhibitory activity of MMP-
13
production and is hence useful as a therapeutic agent for articular rheumatism, osteoarthritis, cancer, etc.
3-Alkyl-2-pyridyl Directing Group-Enabled C2 Selective C–H Silylation of Indoles and Pyrroles via an Iridium Catalyst
作者:Hui Sun、Yi Cheng、Houyun Teng、Xiaoqi Chen、Xiaokang Niu、Hao Yang、Yu-Ming Cui、Li-Wen Xu、Lei Yang
DOI:10.1021/acs.joc.2c01385
日期:2022.10.7
An iridium-catalyzed, directing group-enabled site selective intra- and intermolecular silylation of indoles and pyrroles with hydrosilanes has been developed under ligand-free conditions. Fine-tuning of the removable 3-alkyl-2-pyridyl directing group was found to be crucial for achieving high yields for C2-silylated indole and pyrrole products. Moreover, the scalability was demonstrated, and further