5-(2-acetylaminoethyl)-2,2,4-trimethyl-2H-1,2-oxazino[2,3-a]indole

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 5-(2-acetylaminoethyl)-2,2,4-trimethyl-2H-1,2-oxazino[2,3-a]indole
• 英文别名: N-[2-(2,2,4-trimethyloxazino[2,3-a]indol-5-yl)ethyl]acetamide
• 化学式: C₁₈H₂₂N₂O₂
• 分子量: 298.385
• InChiKey: FXFOCERAMZNZPA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  43.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  Nb-acetyl-1-hydroxytryptamine 在 盐酸 、 potassium tert-butylate 作用下， 以 甲醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 73.0h， 生成 5-(2-acetylaminoethyl)-2,2,4-trimethyl-2H-1,2-oxazino[2,3-a]indole
  参考文献：
  名称：

  Reactions of 1-Hydroxyindoles with p-Toluenesulfonyl Chloride and p-Toluenesulfonic Acid

  摘要：

  1-Hydroxyindoles produced novel types of compounds such as 4-substituted indoles and 4H-1, 3-dioxolo[4,5-b]indoles upon reaction with p-toluenesulfonyl chloride in acetone. Contrastively, 5-tosyloxyindole and 2H-1,2-oxazino[2, 3-a]indole were generated upon reaction with p-toluenesulfonic acid in acetone.

  DOI：

  10.3987/com-00-9038

文献信息

• Reactions of 1-Hydroxyindoles with p-Toluenesulfonyl Chloride and p-Toluenesulfonic Acid
  作者：Masanori Somei、Fumio Yamada、Aya Goto、Masumi Hayashi、Masakazu Hasegawa

  DOI：10.3987/com-00-9038

  日期：——

  1-Hydroxyindoles produced novel types of compounds such as 4-substituted indoles and 4H-1, 3-dioxolo[4,5-b]indoles upon reaction with p-toluenesulfonyl chloride in acetone. Contrastively, 5-tosyloxyindole and 2H-1,2-oxazino[2, 3-a]indole were generated upon reaction with p-toluenesulfonic acid in acetone.