1-benzyl-4-((4-isopropylphenoxy)methyl)-1H-1,2,3-triazole

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-benzyl-4-((4-isopropylphenoxy)methyl)-1H-1,2,3-triazole
• 英文别名: 1-Benzyl-4-[(4-isopropylphenoxy)methyl]triazole；1-benzyl-4-[(4-propan-2-ylphenoxy)methyl]triazole
• 化学式: C₁₉H₂₁N₃O
• 分子量: 307.395
• InChiKey: ORUQVGKHAZGLGL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  23
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  39.9
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-benzyl-4-((4-isopropylphenoxy)methyl)-1H-1,2,3-triazole 在 双氧水 、 三氟乙酸 作用下， 以 水 为溶剂， 生成 1-苄基-4-(羟基甲基)-1H-1,2,3-噻唑
  参考文献：
  名称：

  用 H2O2–CF3CO2H 氧化 1,4-二取代-1,2,3-三唑：有效合成 1,2,3-三唑 3-氧化物

  摘要：

  摘要 通过 H2O2-CF3CO2H 系统介导的相应 1,4-二取代-1,2,3-三唑的氧化，通过简单的方案以良好的产率获得了一组 1,2,3-三唑-3-氧化物。高效率。图形概要

  DOI：

  10.1080/00397911.2019.1566473
• 作为产物：
  描述：

  4-异丙基苯酚 在 copper(ll) sulfate pentahydrate 、 potassium carbonate 、 sodium ascorbate 作用下， 以 水 、 N,N-二甲基甲酰胺 、 叔丁醇 为溶剂， 反应 18.0h， 生成 1-benzyl-4-((4-isopropylphenoxy)methyl)-1H-1,2,3-triazole
  参考文献：
  名称：

  Synthesis, QSAR and anticandidal evaluation of 1,2,3-triazoles derived from naturally bioactive scaffolds

  摘要：

  In the present study, we used eight natural precursors (1a-h) with most of them having promising antimicrobial activities and synthesised their novel 1,2,3-triazole derivatives (3a-h). In the reaction sequences, the precursor compounds (1a-h) were converted to their respective alkyne (2a-h) followed by addition of benzyl azide freshly prepared by the reaction of benzyl bromide with sodium azide using [3 + 2] azide-alkyne cycloaddition strategy. Structural elucidation of all the triazole derivatives was done using FT-IR, H-1, C-13 NMR, mass and elemental analysis techniques. The single crystal X-ray diffraction for 3d was also recorded. The result of in vitro anticandidal activity performed against three different strains of Candida showed that compound 3e was found superior/comparable to fluconazole (FLC) with IC50 values of 0.044 mu g/mL against Candida albicans (ATCC 90028), 12.022 mu g/mL against Candida glabrata (ATCC 90030), and 3.60 mu g/mL against Candida tropicalis (ATCC 750). Moreover, at their IC50 values, compounds 3e and 3h showed <5% hemolysis which indicates the non-toxic behaviour of these inhibitors. Cytotoxicity assay was also performed on VERO cell line and all the derivatives were found nontoxic up to the concentration of 10.0 mu g/mL. The in silico technique of 3D-QSAR was applied to establish structure activity relationship of the synthesized compounds. The results reveal the molecular fragments that play an essential role in improving the anticandidal activity. (C) 2015 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2015.02.007

文献信息

• Oxidation of 1,4-disubstituted-1,2,3-triazoles with H₂O₂-CF₃CO₂H: efficient synthesis of 1,2,3-triazole 3-oxides
  作者：Norberto González-Mojica、Leticia Almazán-Sánchez、Jesús G. García-Torres、Ivette Santana-Martinez、Diego Martínez-Otero、Miguel A. Sánchez-Carmona、Erick Cuevas-Yañez

  DOI：10.1080/00397911.2019.1566473

  日期：2019.3.4

  Abstract A collection of 1,2,3-triazole-3-oxides was obtained from oxidation of the corresponding 1,4-disubstituted-1,2,3-triazoles mediated by a H2O2-CF3CO2H system through a simple protocol in good yields showing high efficiency. Graphical Abstract

  摘要 通过 H2O2-CF3CO2H 系统介导的相应 1,4-二取代-1,2,3-三唑的氧化，通过简单的方案以良好的产率获得了一组 1,2,3-三唑-3-氧化物。高效率。图形概要
• Synthesis, QSAR and anticandidal evaluation of 1,2,3-triazoles derived from naturally bioactive scaffolds
  作者：Mohammad Irfan、Babita Aneja、Umesh Yadava、Shabana I. Khan、Nikhat Manzoor、Constantin G. Daniliuc、Mohammad Abid

  DOI：10.1016/j.ejmech.2015.02.007

  日期：2015.3

  In the present study, we used eight natural precursors (1a-h) with most of them having promising antimicrobial activities and synthesised their novel 1,2,3-triazole derivatives (3a-h). In the reaction sequences, the precursor compounds (1a-h) were converted to their respective alkyne (2a-h) followed by addition of benzyl azide freshly prepared by the reaction of benzyl bromide with sodium azide using [3 + 2] azide-alkyne cycloaddition strategy. Structural elucidation of all the triazole derivatives was done using FT-IR, H-1, C-13 NMR, mass and elemental analysis techniques. The single crystal X-ray diffraction for 3d was also recorded. The result of in vitro anticandidal activity performed against three different strains of Candida showed that compound 3e was found superior/comparable to fluconazole (FLC) with IC50 values of 0.044 mu g/mL against Candida albicans (ATCC 90028), 12.022 mu g/mL against Candida glabrata (ATCC 90030), and 3.60 mu g/mL against Candida tropicalis (ATCC 750). Moreover, at their IC50 values, compounds 3e and 3h showed <5% hemolysis which indicates the non-toxic behaviour of these inhibitors. Cytotoxicity assay was also performed on VERO cell line and all the derivatives were found nontoxic up to the concentration of 10.0 mu g/mL. The in silico technique of 3D-QSAR was applied to establish structure activity relationship of the synthesized compounds. The results reveal the molecular fragments that play an essential role in improving the anticandidal activity. (C) 2015 Elsevier Masson SAS. All rights reserved.