1-(4-chlorophenyl)-6,6-dimethyl-3-phenyl-6,7-dihydro-1Hindol-4(5H)-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 1-(4-chlorophenyl)-6,6-dimethyl-3-phenyl-6,7-dihydro-1Hindol-4(5H)-one
• 英文别名: 1-(4-Chlorophenyl)-6,6-dimethyl-3-phenyl-5,7-dihydroindol-4-one；1-(4-chlorophenyl)-6,6-dimethyl-3-phenyl-5,7-dihydroindol-4-one
• 化学式: C₂₂H₂₀ClNO
• 分子量: 349.86
• InChiKey: OWLSNAPIRAIREC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  25
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  22
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2-(4-氯苯胺)-1-苯基-1-乙酮 、 5,5-二甲基-1,3-环己二酮 在 溶剂黄146 作用下， 反应 0.5h， 以81%的产率得到1-(4-chlorophenyl)-6,6-dimethyl-3-phenyl-6,7-dihydro-1Hindol-4(5H)-one
  参考文献：
  名称：

  Synthesis of substituted 1,3-diaryl-6,7-dihydro-1H-indol-4(5H)-ones from 1-aryl-2-arylaminoethanones

  摘要：

  本发明公开了一种以 1-芳基-2-芳基氨基乙酮和取代的环己烷-1,3-二酮为原料，通过醋酸介导反应合成 1,3-二芳基-6,7-二氢-1H-吲哚-4(5H)-酮的简单而新颖的方法。

  DOI：

  10.1039/c4ra03975k

文献信息

• Synthesis of tetrahydro-4H-indol-4-one derivatives catalyzed by carbonaceous material
  作者：Chunmei Li、Xuezheng Liang、Furen Zhang、Chenze Qi

  DOI：10.1016/j.catcom.2014.12.026

  日期：2015.3

  An efficient, high yielding method has been developed for the synthesis of diversity tetrahydro-4H-indol-4-one derivatives via a three component, one pot domino reaction from cyclohexane-1,3-diones, amines and nitrostyrenes using carbon functionalized with sulfonic acid group carbonaceous material as catalyst for the first time. The reaction was carried out in water, affording good to excellent yields in short time. The advantages of atom and step economy, green, and scope make this reaction a powerful tool for assembling heterocyclic scaffolds of general chemical and biomedical interest. (C) 2014 Elsevier B.V. All rights reserved.
• Synthesis of substituted 1,3-diaryl-6,7-dihydro-1H-indol-4(5H)-ones from 1-aryl-2-arylaminoethanones
  作者：Selvam Kaladevi、Jeyaraman Sridhar、Brahmanandan Abhilashamole、Shanmugam Muthusubramanian、Nattamai Bhuvanesh

  DOI：10.1039/c4ra03975k

  日期：——

  A simple and novel method for the synthesis of 1,3-diaryl-6,7-dihydro-1H-indol-4(5H)-ones from 1-aryl-2-arylaminoethanones and substituted cyclohexane-1,3-diones through acetic acid mediated reaction is disclosed.

  本发明公开了一种以 1-芳基-2-芳基氨基乙酮和取代的环己烷-1,3-二酮为原料，通过醋酸介导反应合成 1,3-二芳基-6,7-二氢-1H-吲哚-4(5H)-酮的简单而新颖的方法。