N-[2-(1H-benzo[d]imidazol-2-yl)phenyl]-2-[4-(2-hydroxyethyl)piperazin-1-yl]acetamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: N-[2-(1H-benzo[d]imidazol-2-yl)phenyl]-2-[4-(2-hydroxyethyl)piperazin-1-yl]acetamide
• 化学式: C₂₁H₂₅N₅O₂
• 分子量: 379.462
• InChiKey: GFHFNDDZERSTJQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.78
• 重原子数：
  28.0
• 可旋转键数：
  6.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  84.49
• 氢给体数：
  3.0
• 氢受体数：
  5.0

反应信息

• 作为产物：
  描述：

  N-羟乙基哌嗪 、 N-[2-(1H-benzo[d]imidazol-2-yl)phenyl]-2-chloroacetamide 以 N,N-二甲基甲酰胺 为溶剂， 反应 12.0h， 以82%的产率得到N-[2-(1H-benzo[d]imidazol-2-yl)phenyl]-2-[4-(2-hydroxyethyl)piperazin-1-yl]acetamide
  参考文献：
  名称：

  Relay recognition of Cu2+ and S2− in water by a simple 2-(2′-aminophenyl)benzimidazole derivatized fluorescent sensor through modulating ESIPT

  摘要：

  A new 2-(2'-aminophenyl)benzimidazole (2-APBI) derivatized fluorescent sensor (L) that behaves relay recognition of Cu2+ and S2- in water solution (pH 7.4) has been developed. Sensor L displays excited-state intramolecular proton transfer (ESIPT) featured two emission bands and performs highly selective and sensitive recognition to Cu2+ through two emissions simultaneous quenching. The on-site formed L-Cu2+ complex exhibits excellent selectivity to S2- with fluorescence "off-on" response via Cu2+ displacement approach, which exerts ESIPT recovery. Thus, through modulation the ESIPT state of sensor I relay recognition of Cu2+ and S2- in water has been achieved. (C) 2013 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.saa.2013.11.091

文献信息

• Relay recognition of Cu2+ and S2− in water by a simple 2-(2′-aminophenyl)benzimidazole derivatized fluorescent sensor through modulating ESIPT
  作者：Lijun Tang、Xin Dai、Mingjun Cai、Jia Zhao、Pei Zhou、Zhenlong Huang

  DOI：10.1016/j.saa.2013.11.091

  日期：2014.3

  A new 2-(2'-aminophenyl)benzimidazole (2-APBI) derivatized fluorescent sensor (L) that behaves relay recognition of Cu2+ and S2- in water solution (pH 7.4) has been developed. Sensor L displays excited-state intramolecular proton transfer (ESIPT) featured two emission bands and performs highly selective and sensitive recognition to Cu2+ through two emissions simultaneous quenching. The on-site formed L-Cu2+ complex exhibits excellent selectivity to S2- with fluorescence "off-on" response via Cu2+ displacement approach, which exerts ESIPT recovery. Thus, through modulation the ESIPT state of sensor I relay recognition of Cu2+ and S2- in water has been achieved. (C) 2013 Elsevier B.V. All rights reserved.