N-pentyl-2-pyridylmethanimine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: N-pentyl-2-pyridylmethanimine
• 英文别名: pentyl-[2]pyridylmethylen-amine；Pentyl-[2]pyridylmethylen-amin
• 化学式: C₁₁H₁₆N₂
• 分子量: 176.261
• InChiKey: OSPMBNNFGUOTQS-ZRDIBKRKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.69
• 重原子数：
  13.0
• 可旋转键数：
  5.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  25.25
• 氢给体数：
  0.0
• 氢受体数：
  2.0

反应信息

• 作为产物：
  描述：

  吡啶-2-甲醛 、 1-氨基戊烷 生成 N-pentyl-2-pyridylmethanimine
  参考文献：
  名称：

  �ber Schwermetallkomplexe bifunktioneller Schiffscher Basen. IV, Schwermetallkomplexe mit Pyridin-2-aldehyd-alkyliminen

  摘要：

  AbstractMit einer Reihe neuer Alkylimine des Pyridin‐2‐aldehydes werden Komplexverbindungen von Eisen, Kupfer, Quecksilber und Zink erhalten. Die permanganatfarbigen Eisen(II)‐komplexe sind innerhalb eines viel größeren pH‐Bereiches beständig als die gleichfarbigen, früher beschriebenen mit Pyridin‐2‐aldehyd‐aryliminen, ihre Bildung eignet sich zum Nachweis von Eisen(II)‐ionen. Auf optischem Wege wird gezeigt, daß die Pyridin‐2‐aldehyd‐alkylimine fähig sind, 2,2′‐Dipyridyl aus seinen Eisen(II)‐komplexen weitestgehend zu verdrängen.

  DOI：

  10.1002/zaac.19572920115
• 作为试剂：
  描述：

  4-Methyl-N-prop-2-ynyl-N-(2,2,2-trichloro-acetyl)-benzenesulfonamide 在 N-pentyl-2-pyridylmethanimine 、 copper(l) chloride 作用下， 以 二氯甲烷 为溶剂， 反应 24.0h， 以75%的产率得到3-Chloro-4-dichloromethyl-1-(toluene-4-sulfonyl)-1,5-dihydro-pyrrol-2-one
  参考文献：
  名称：

  5-exo Atom transfer cyclisation onto alkynes mediated by copper(I) complexes

  摘要：

  Multidentate amine derived copper(I) halide complexes mediate the atom transfer radical cyclisation of 1-halo-N-propargylacetamides. While cyclisation of trichloro- and dichloroacetamide derivatives leads to alpha,beta -unsaturated gamma -lactams containing the gem-dihalide functional group, monohaloacetamides give rise to either cyclised atom transfer or reduction products depending upon the solvent and catalyst used. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(01)00060-0

文献信息

• [EN] POLYMERIC NANOPARTICLES FOR ULTRASOUND IMAGING AND THERAPY<br/>[FR] NANOPARTICULES POLYMÈRES UTILISÉES POUR L'IMAGERIE ET LE TRAITEMENT PAR ULTRASONS
  申请人：UNIV MICHIGAN

  公开号：WO2013055791A1

  公开（公告）日：2013-04-18

  Provided herein are nanobubbles designed for use in ultrasound-mediated ablation of cancer cells. The nanobubbles undergo ultrasound-mediated cavitation at an ablation threshold which is significantly decreased, relative to standard ultrasound- mediated treatment of cancer cells. In exemplary embodiments, the nanobubbles comprise an amphiphilic ABC triblock copolymer, wherein block A comprises a hydrophilic polymer, block B comprises a crosslinking polymer, and block C comprises a hydrophobic copolymer comprising (i) methyl methacrylate (MMA) and (ii) a fluorinated monomer, wherein the fluorinated monomer is present in the hydrophobic copolymer of block C at 25 mole percent or less. Related treatment and diagnostic methods, as well as materials relating to the nanobubbles are provided herein. Methods of making a random copolymer are furthermore provided herein.

  本文提供了设计用于超声介导癌细胞消融的纳米气泡。这些纳米气泡在消融阈值下经历超声介导的空化作用，相对于标准的超声介导癌细胞治疗，其消融阈值显著降低。在示范性实施例中，这些纳米气泡包括一种两性ABC三嵌段共聚物，其中嵌段A包括一个亲水性聚合物，嵌段B包括一个交联聚合物，而嵌段C包括一个亲脂性共聚物，包括(i) 甲基丙烯酸甲酯（MMA）和(ii) 一种氟化单体，其中氟化单体以25摩尔%或更低的比例存在于嵌段C的亲脂性共聚物中。此外，本文还提供了与纳米气泡相关的治疗和诊断方法，以及相关材料。此外，本文还提供了制备随机共聚物的方法。
• Method for Detecting Target Substance and Target-Substance Detection Kit
  申请人：Ogawa Miki

  公开号：US20090000360A1

  公开（公告）日：2009-01-01

  The present invention provides a method for detecting a target substance by detecting the presence or concentration of a target substance in a sample solution by bringing the sample solution into contact with a detecting element including a detecting part and a non-detecting part and detecting the presence or number of a magnetic label (magnetic marker) present in the vicinity of the surface of the detecting part and provides a target-substance detection kit. The surface potential ψ 1 of the magnetic label in the sample solution, the surface potential ψ 2 of the detecting parts and the surface potential ψ 3 of the non-detecting part satisfy any one of the following relationships i) to iv): ψ 1 ψ 3 >0 and ψ 2 =0,  i) ψ 1 ψ 2 <0 and ψ 3 =0,  ii) ψ 1 ψ 2 <0, ψ 2 ψ 3 >0, and |ψ 2 |>|ψ 3 |, and  iii) ψ 1 ψ 2 <0 and ψ 2 ψ 3 <0;  iv) and the target substance borne by the magnetic label is captured by a primary capturing body borne by the detecting part, or the target substance captured by a primary capturing body borne by the detecting part is captured by a secondary capturing body borne by the magnetic label.

  本发明提供了一种通过检测样品溶液中目标物质的存在或浓度来检测目标物质的方法，该方法通过将样品溶液与包括检测部分和非检测部分的检测元件接触，并检测存在于检测部分表面附近的磁性标记（磁性标记物）的存在或数量来实现，并提供了目标物质检测工具包。磁性标记物在样品溶液中的表面电位ψ1，检测部分的表面电位ψ2和非检测部分的表面电位ψ3满足以下关系之一：i）ψ1ψ3>0且ψ2=0，ii）ψ1ψ2<0且ψ3=0，iii）ψ1ψ2<0，ψ2ψ3>0且|ψ2|>|ψ3|，以及iv）ψ1ψ2<0且ψ2ψ3<0；并且由磁性标记物携带的目标物质被检测部分携带的一次捕获体捕获，或者由检测部分携带的一次捕获体捕获的目标物质被磁性标记物携带的二次捕获体捕获。
• STRUCTURE, TARGET SUBSTANCE-DETECTING ELEMENT AND TARGET SUBSTANCE-DETECTING KIT
  申请人：Ban Kazuhiro

  公开号：US20090005495A1

  公开（公告）日：2009-01-01

  According to the present invention, there can be provided a structure preventing the nonspecific adsorption, and a target substance-detecting element and a target substance-detecting kit. A first aspect of the present invention is a structure including: a substrate; and a membrane, present on the surface of the substrate, having a polymer of a monomer represented by the following General Formula (1) or (2): (wherein R represents H or CH 3 ; x represents an integer of 2 to 5, and y represents an integer of 1 to 7, with the proviso that x+y=an integer of 3 to 10), and (wherein R 1 =H or CH 3 , and R 2 represents O or NH; a represents an integer of 2 to 5, and b represents an integer of 1 to 7, with the proviso that a+b=an integer of 3 to 10.)

  根据本发明，可以提供一种防止非特异性吸附的结构，以及一种目标物质检测元件和目标物质检测试剂盒。本发明的第一方面是一种结构，包括：基板；以及存在于基板表面上的膜，其具有由以下通式（1）或（2）表示的单体的聚合物：（其中R表示H或CH3；x表示2至5的整数，y表示1至7的整数，但x+y等于3至10的整数），以及（其中R1=H或CH3，R2表示O或NH；a表示2至5的整数，b表示1至7的整数，但a+b等于3至10的整数）。
• Polymer
  申请人：Haddleton David

  公开号：US20080300348A1

  公开（公告）日：2008-12-04

  The application provides a method of producing a comb polymer comprising the steps of: (a) Providing: (i) a plurality of monomers which are linear, branched or star-shaped, substituted or non-substituted, and have an olefinically unsaturated moiety, the olefinically unsaturated moiety being capable of undergoing addition polymerisation; (ii) an initiator compound; the initiator compound comprising a homolytically cleavable bond. (iii) a catalyst capable of catalysing the polymerisation of the monomer; and (b) Causing the catalyst to catalyse, in combination with the initiator, the polymerisation of a plurality of the monomers to produce the comb polymer. Catalysts and polymers obtainable by the process are also provided. Preferably, the comb polymer is capable of binding proteins and may be produced from monomers which are alkoxy polyethers, such as poly(alkyleneglycol) or polytetrahydrofuran.

  该应用程序提供了一种生产梳状聚合物的方法，包括以下步骤：(a) 提供：(i) 一种具有烯丙基不饱和基团的线性、支化或星形单体，取代或非取代，该烯丙基不饱和基团能够进行加成聚合；(ii) 一种引发剂化合物；该引发剂化合物包括一个均裂性可裂解键。(iii) 一种催化剂，能够催化单体的聚合；以及(b) 使催化剂与引发剂相结合，催化多种单体的聚合，从而产生梳状聚合物。该过程获得的催化剂和聚合物也被提供。优选地，该梳状聚合物能够结合蛋白质，并且可以由烷氧基聚醚单体制成，例如聚(烷基二醇)或聚四氢呋喃。
• METHOD FOR DETECTING TARGET SUBSTANCE AND TARGET-SUBSTANCE DETECTION KIT
  申请人：Ogawa Miki

  公开号：US20110136264A1

  公开（公告）日：2011-06-09

  The present invention provides a method for detecting a target substance by detecting the presence or concentration of a target substance in a sample solution by bringing the sample solution into contact with a detecting element including a detecting part and a non-detecting part and detecting the presence or number of a magnetic label (magnetic marker) present in the vicinity of the surface of the detecting part and provides a target-substance detection kit. The surface potential ψ 1 of the magnetic label in the sample solution, the surface potential ψ 2 of the detecting part, and the surface potential ψ 3 of the non-detecting part satisfy any one of the following relationships i) to iv): ψ 1 ψ 3 >0 and ψ 2 =0,  i) ψ 1 ψ 2 <0 and ψ 3 =0,  ii) ψ 1 ψ 2 <0, ψ 2 ψ 3 >0, and |ψ 2 |>|ψ 3 |, and  iii) ψ 1 ψ 2 <0 and ψ 2 ψ 3 <0;  iv) and the target substance borne by the magnetic label is captured by a primary capturing body borne by the detecting part, or the target substance captured by a primary capturing body borne by the detecting part is captured by a secondary capturing body borne by the magnetic label.

  本发明提供了一种检测目标物质的方法，通过将样品溶液与包括检测部分和非检测部分的检测元件接触，检测样品溶液中目标物质的存在或浓度，并检测靠近检测部分表面的磁性标记（磁性标记）的存在或数量，并提供目标物质检测工具包。磁性标记在样品溶液中的表面电位ψ1，检测部分的表面电位ψ2和非检测部分的表面电位ψ3满足以下关系之一：i）ψ1ψ3>0且ψ2=0，ii）ψ1ψ2<0且ψ3=0，iii）ψ1ψ2<0，ψ2ψ3>0且|ψ2|>|ψ3|，以及iv）ψ1ψ2<0且ψ2ψ3<0;并且由磁性标记携带的目标物质被检测部分携带的主要捕获体捕获，或者由检测部分携带的主要捕获体捕获的目标物质被磁性标记携带的次要捕获体捕获。