4-methyl-5,6,7,8-tetrahydroisoquinoline

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 4-methyl-5,6,7,8-tetrahydroisoquinoline
• 英文别名: 4-methyl-5,6,7,8-tetrahydroquinoline；4-Methyl-5,6,7,8-tetrahydroquinolin
• 化学式: C₁₀H₁₃N
• 分子量: 147.22
• InChiKey: UMZQJLLAMXBGJG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  4-methyl-5,6,7,8-tetrahydroisoquinoline 、 香草醛 生成 [2-methoxy-4-[(E)-(4-methyl-6,7-dihydro-5H-isoquinolin-8-ylidene)methyl]phenyl] acetate
  参考文献：
  名称：

  CROSSLEY, R.

  摘要：

  DOI：
• 作为产物：
  描述：

  4-甲基喹啉 在 十六羰基六铑 氢气 作用下， 200.0 ℃ 、980.59 kPa 条件下， 反应 20.0h， 以47%的产率得到4-methyl-5,6,7,8-tetrahydroisoquinoline
  参考文献：
  名称：

  水煤气变换条件下喹啉和异喹啉的铑催化加氢

  摘要：

  在催化量的铑羰基簇的存在下，通过一氧化碳和水可以在含氮环中选择性地氢化多种喹啉和异喹啉。这些反应为制备 1,2,3,4-四氢喹啉和 1,2,3,4-四氢异喹啉提供了一种有用的方法，它们是合成异喹啉生物碱和其他生物活性氮化合物的关键中间体。

  DOI：

  10.1246/bcsj.62.2968

文献信息

• A simple, tandem approach to the construction of pyridine derivatives under metal-free conditions: a one-step synthesis of the monoterpene natural product, (−)-actinidine
  作者：Dilipkumar Uredi、Damoder Reddy Motati、E. Blake Watkins

  DOI：10.1039/c9cc01097a

  日期：——

  followed by concomitant cyclization through an allenyl intermediate to afford pyridines in excellent yields, with water as the sole by-product. This mild strategy is also suitable for functionalization of natural products or other advanced intermediates having α,β-unsaturated carbonyl functionality. The utility of the present protocol was showcased with the synthesis of the monoterpene alkaloid, (−)-actinidine

  已经开发了一种简单的模块化单步合成法，可从容易获得的α，β-不饱和羰基化合物和炔丙基胺合成各种取代的吡啶。本方案具有广泛的底物范围，并允许在温和且无金属的条件下通过选择性控制取代模式来接近多取代的吡啶。该反应涉及亚胺的形成，随后伴随通过烯基中间体的环化，以优异的收率得到吡啶，其中水是唯一的副产物。这种温和的策略也适用于天然产物或其他具有α，β-不饱和羰基官能团的高级中间体的官能化。本协议的效用通过单蚁生物碱（-）-in啶，一种与蚂蚁相关的虹彩样生物的合成得以展示。
• NOVEL METHODS FOR PREPARATION OF SUBSTITUTED PYRIDINES AND RELATED NOVEL COMPOUNDS
  申请人：Watkins Edmond Blake

  公开号：US20200095245A1

  公开（公告）日：2020-03-26

  The present invention relates to novel methods of preparation of substituted pyridines and the compounds produced therefrom. In particular, the present invention provides efficient methods for the construction of diversely substituted pyridines, with varying substitution patterns under simple and metal-free conditions with high atom- and pot-economy and excellent functional group tolerance, and which are useful for the synthesis of natural products.

  本发明涉及取代吡啶的新的制备方法及其由此产生的化合物。特别是，本发明提供了一种高效的方法，用于构建不同取代的吡啶，具有不同的取代模式，在简单和无金属条件下具有高原子经济和锅经济以及优良的功能团耐受性，并且适用于天然产物的合成。
• COMPOUND HAVING PYRIMIDINE RING STRUCTURE AND ORGANIC ELECTROLUMINESCENCE DEVICE
  申请人：HODOGAYA CHEMICAL CO., LTD.

  公开号：US20200277272A1

  公开（公告）日：2020-09-03

  [Object] It is an object of the present invention to provide, as a material for organic EL device having high efficiency and high durability, an organic compound having excellent characteristics such as excellent electron injection/transport performance, hole blocking performance, and high stability in a film state, and an organic EL device having high efficiency and high durability, which is obtained by using this compound. [Solving Means] A compound having a pyrimidine ring structure, the compound being represented by the following general formula (1). (In the formula, A 1 represents a substituted or unsubstituted aromatic heterocyclic group. Ar 1 represents a substituted or unsubstituted aromatic hydrocarbon group, a substituted or unsubstituted aromatic heterocyclic group, or a substituted or unsubstituted fused polycyclic aromatic group. Ar 2 represents a deuterium atom, a trimethylsilyl group, a triphenylsilyl group, a substituted or unsubstituted aromatic hydrocarbon group, a substituted or unsubstituted aromatic heterocyclic group, or a substituted or unsubstituted fused polycyclic aromatic group. m represents an integer of 1 to 3, n represents an integer of 0 to 2, and o represents an integer of 1 to 2. In a case where m is an integer of two or more, a plurality of Ar 1 bonded to the same pyrimidine ring may be the same or different from each other. In a case where n is an integer of two, a plurality of Ar 2 bonded to the same pyrimidine ring may be the same or different from each other. In a case where o is an integer of two, a plurality of A 1 bonded to the same pyrimidine ring may be the same or different from each other. However, the sum of the integers of m, n, and o is 4 or less. Note that in a case where n is 0 , Ar 2 represents a hydrogen atom.)

  [目标] 本发明的目标是提供一种用作有高效率和高耐久性的有机EL器件材料的有机化合物，该有机化合物具有优异的特性，如优异的电子注入/输运性能、孔阻挡性能和在薄膜状态下的高稳定性，并且使用该化合物制备的有机EL器件具有高效率和高耐久性。 [解决方法] 一种具有嘧啶环结构的化合物，该化合物由以下通式（1）表示。（在公式中，A1表示取代或未取代的芳香杂环基团。Ar1表示取代或未取代的芳香烃基团、取代或未取代的芳香杂环基团或取代或未取代的融合多环芳香基团。Ar2表示氘原子、三甲基硅基团、三苯基硅基团、取代或未取代的芳香烃基团、取代或未取代的芳香杂环基团或取代或未取代的融合多环芳香基团。m表示1到3的整数，n表示0到2的整数，o表示1到2的整数。在m为2或更多的整数的情况下，与同一嘧啶环键合的多个Ar1可以相同或不同。在n为2的整数的情况下，与同一嘧啶环键合的多个Ar2可以相同或不同。在o为2的整数的情况下，与同一嘧啶环键合的多个A1可以相同或不同。但是，m、n和o的整数之和为4或更小。请注意，在n为0的情况下，Ar2表示氢原子。）
• NOVEL MODULATORS OF SPHINGOSINE PHOSPHATE RECEPTORS
  申请人：Roberts Edward

  公开号：US20100010001A1

  公开（公告）日：2010-01-14

  Compounds that activate a sphingosine-1-phosphate receptor of the subtype 1 are provided. Certain compounds selectively activate the receptor subtype 1 in relation to the sphinogosine-4-phosphate receptor subtype 3. Uses and methods of inventive compounds for treatment of malconditions wherein activation, agonism, inhibition or antagonism of the S1P1 is medically indicated are provided.

  提供了激活1型鞘氨醇-1-磷酸受体的化合物。某些化合物在与鞘氨醇-4-磷酸受体亚型3相比，选择性地激活受体亚型1。提供了用于治疗需要医学上激活、激动、抑制或拮抗S1P1的恶性疾病的创新化合物的用途和方法。
• NITROGEN-CONTAINING HETEROCYCLIC COMPOUND AND BACTERICIDE FOR AGRICULTURAL AND HORTICULTURAL USE
  申请人：Nippon Soda Co., Ltd.

  公开号：EP2223919A1

  公开（公告）日：2010-09-01

  The present invention provides a nitrogen-containing heterocyclic compound represented by the formula (I) (wherein, A-B represents any one of the formula (II): C=N, the formula (III): CH-NR9 and the formula (IV): N-C(=Y); R1, R2, R3 and R4 independently represent hydrogen atom, a halogen atom, a C1-20 alkyl group or the like; R5, R6, R7 and R8 independently represent hydrogen atom, a halogen atom, a C1-20 alkyl group or the like; X represents a halogen atom or the like; and n represents an integer of 0 to 4; in the formula (III), R9 represents hydrogen atom, a C1-20 alkyl group or the like; in the formula (IV), Y represents oxygen atom or sulfur atom.) and the salt thereof. The present invention also provides a fungicide for agricultural and horticultural use containing at least one of the said nitrogen-containing heterocyclic compound or the salt thereof as an active ingredient.

  本发明提供了一种由式(I)代表的含氮杂环化合物（其中，A-B代表式(II)中的任意一种：C=N、式(III)：CH-NR9和式(IV)中的任意一种：N-C(＝Y)；R1、R2、R3和R4独立地代表氢原子、卤素原子、C1-20烷基或类似物；R5、R6、R7和R8独立地代表氢原子、卤素原子、C1-20烷基或类似物；X代表卤素原子或类似物；n代表0至4的整数；在式(III)中，R9代表氢原子、C1-20烷基或类似物；在式(IV)中，Y代表氧原子或硫原子)及其盐。本发明还提供了一种农业和园艺用杀真菌剂，该杀真菌剂含有至少一种上述含氮杂环化合物或其盐作为活性成分。