6-hydroxy-2-methylheptanecarboxylic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羟基酸及其衍生物
• 英文名称: 6-hydroxy-2-methylheptanecarboxylic acid
• 英文别名: 6-Hydroxy-2-methylheptanoic acid
• 化学式: C₈H₁₆O₃
• 分子量: 160.213
• InChiKey: PCPUJRVQXKYONA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  二甲基环已酮 在 双氧水 作用下， 以 水 、 叔丁醇 为溶剂， 反应 21.0h， 以72%的产率得到6-hydroxy-2-methylheptanecarboxylic acid
  参考文献：
  名称：

  二芳基二硒化物和相关化合物作为氧转移剂

  摘要：

  介绍了二芳基二硒化物及相关化合物作为转移剂的应用进展。综述仅限于具有吸电子取代基的二芳基二硒化物，如硝基、三氟甲基、氨基甲酰基苯基和聚合二硒化物 PADS 和 PPDS。描述了它们的合成方法。这些化合物被用作不同有机化合物的简单和多电子氢过氧化物氧化的有效催化剂。描述了官能团的转化、环烷酮环收缩、环缩合和富电子芳烃的降解。讨论了涉及 Se(II) 和 Se(IV) 中间体的反应机理。

  DOI：

  10.1080/10426500801900956

文献信息

• Biomarkers for diagnosing multiple sclerosis, and methods thereof
  申请人：Phenomenome Discoveries Inc.

  公开号：EP2644588A2

  公开（公告）日：2013-10-02

  The present invention describes methods for the diagnosis and differential diagnosis of the different forms of multiple sclerosis. The methods measure the intensities of specific small molecules called metabolites in samples from patients with clinically diagnosed relapsing-remitting or primary-progressive forms of multiple sclerosis and compare these intensities to the intensities observed in a population of healthy individuals, thus identifying markers of multiple sclerosis. A method is also provided for the differential diagnosis of subjects afflicted with relapsing-remitting multiple sclerosis from secondary-progressive multiple sclerosis.

  本发明描述了诊断和鉴别诊断不同形式多发性硬化症的方法。这些方法测量临床诊断为复发-缓解型或原发性进展型多发性硬化症患者样本中被称为代谢物的特定小分子的强度，并将这些强度与在健康人群中观察到的强度进行比较，从而确定多发性硬化症的标记物。此外，还提供了一种方法，用于鉴别诊断复发缓解型多发性硬化症患者和继发性进展型多发性硬化症患者。
• BIOMARKERS FOR DIAGNOSING MULTIPLE SCLEROSIS, AND METHODS THEREOF
  申请人：Cook Lisa

  公开号：US20100062472A1

  公开（公告）日：2010-03-11

  The present invention describes methods for the diagnosis and differential diagnosis of the different forms of multiple sclerosis The methods measure the intensities of specific small molecules called metabolites in samples from patients with clinically diagnosed relapsmg-remittmg or primary-progressive forms of multiple sclerosis and compare these intensities to the intensities observed in a population of healthy individuals, thus identifying markers of multiple sclerosis A method is also provided for the differential diagnosis of subjects afflicted with relapsing-renitting multiple sclerosis from secondary-progressive multiple sclerosis.
• Diaryl Diselenides and Related Compounds as Oxygen-Transfer Agents
  作者：Mirosław Giurg、Ludwik Syper

  DOI：10.1080/10426500801900956

  日期：2008.4.1

  is presented. The review is limited to the diaryl diselenides having electron-withdrawing substituents, such as nitro, trifluoromethyl, carbamoylphenyl, and polymeric diselenides PADS and PPDS. The methods of their synthesis are described. These compounds are used as effective catalyst for a simple and multi-electron hydroperoxide oxidation of different organic compounds. Transformation of functional

  介绍了二芳基二硒化物及相关化合物作为转移剂的应用进展。综述仅限于具有吸电子取代基的二芳基二硒化物，如硝基、三氟甲基、氨基甲酰基苯基和聚合二硒化物 PADS 和 PPDS。描述了它们的合成方法。这些化合物被用作不同有机化合物的简单和多电子氢过氧化物氧化的有效催化剂。描述了官能团的转化、环烷酮环收缩、环缩合和富电子芳烃的降解。讨论了涉及 Se(II) 和 Se(IV) 中间体的反应机理。