1-(N-benzylamino)-1-cyano-3-methylcyclohexane

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(N-benzylamino)-1-cyano-3-methylcyclohexane
• 英文别名: 1-(Benzylamino)-3-methylcyclohexane-1-carbonitrile
• 化学式: C₁₅H₂₀N₂
• 分子量: 228.337
• InChiKey: SHLYDXGQRHNDKH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  35.8
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  三甲基氰硅烷 、 3-甲基环己酮 在 SiW/Al₂O₃ 作用下， 以 乙腈 为溶剂， 反应 0.5h， 以95%的产率得到1-(N-benzylamino)-1-cyano-3-methylcyclohexane
  参考文献：
  名称：

  γ-Al₂O₃-Supported 12-Tungstosilicic Acid as an Efficient Heterogeneous Catalyst for the Synthesis of α-Aminonitrile

  摘要：

  The multicomponent Strecker reaction using trimethylsilyle cyanide was performed in very short reaction times, and alpha-aminonitriles were prepared in excellent yields in the presence of a catalytic amount of alumina-supported tungstosilicic acid.

  DOI：

  10.1080/00397910802222571

文献信息

• K₅CoW₁₂O₄₀ · 3H₂O: Heterogeneous Catalyst for the Strecker‐Type Aminative Cyanation of Aldehydes and Ketones
  作者：Ezzat Rafiee、Alireza Azad

  DOI：10.1080/00397910701198914

  日期：2007.4.1

  Abstract One‐step synthesis of α‐aminonitriles was successfully carried out by a three‐component condensation of aldehydes or ketones, amines, and potassium cyanide in the presence of a catalytic amount of K5CoW12O40·3H2O as an efficient, reusable, and nontoxic catalyst.

  摘要 在催化量的 K5CoW12O40·3H2O 作为一种高效、可重复使用且无毒的催化剂存在下，通过醛或酮、胺和氰化钾的三组分缩合成功地一步合成 α-氨基腈。
• Indium trichloride catalyzed one-step synthesis of α-amino nitriles by a three-component condensation of carbonyl compounds, amines and potassium cyanide
  作者：Brindaban C Ranu、Suvendu S Dey、Alakananda Hajra

  DOI：10.1016/s0040-4020(02)00132-1

  日期：2002.3

  A simple and general method has been developed for the synthesis of α-aminonitriles by a one-pot three-component condensation of aldehydes or ketones, amines and potassium cyanide in THF in presence of a catalytic amount of indium trichloride.

  已经开发了一种简单且通用的方法，该方法是在催化量的三氯化铟存在下，在THF中通过一锅三组分缩合醛或酮，胺和氰化钾来合成α-氨基腈。
• Rafiee, Ezzat; Rashidzadeh, Solmaz; Eavani, Sara, Bulletin of the Chemical Society of Ethiopia, 2010, vol. 24, # 2, p. 209 - 215
  作者：Rafiee, Ezzat、Rashidzadeh, Solmaz、Eavani, Sara、Joshaghani, Mohammad

  DOI：——

  日期：——
• γ-Al₂O₃-Supported 12-Tungstosilicic Acid as an Efficient Heterogeneous Catalyst for the Synthesis of α-Aminonitrile
  作者：Ezzat Rafiee、Solmaz Rashidzadeh、Mohammad Joshaghani、Hadi Chalabeh、Kambiz Afza

  DOI：10.1080/00397910802222571

  日期：2008.8.19

  The multicomponent Strecker reaction using trimethylsilyle cyanide was performed in very short reaction times, and alpha-aminonitriles were prepared in excellent yields in the presence of a catalytic amount of alumina-supported tungstosilicic acid.