十九烷酸N-甲酰胺 | 6212-93-7

• 物质功能分类: 化学试剂 - 有机试剂 - 酰胺
• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: 十九烷酸N-甲酰胺
• 中文别名: N-甲基十九酰胺
• 英文名称: Nonadecanoic acid methylamide
• 英文别名: N-methylnonadecanamide
• CAS: 6212-93-7
• 化学式: C₂₀H₄₁NO
• 分子量: 311.552
• InChiKey: JJOVCQBPDCSFDT-UHFFFAOYSA-N

物化性质

• 熔点：
  91-94 °C
• 沸点：
  451.57°C (rough estimate)
• 密度：
  0.9304 (rough estimate)

计算性质

• 辛醇/水分配系数(LogP)：
  7.7
• 重原子数：
  22
• 可旋转键数：
  17
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  29.1
• 氢给体数：
  1
• 氢受体数：
  1

安全信息

• 安全说明：
  S24/25
• 海关编码：
  2924199090

反应信息

• 作为产物：
  描述：

  十九酰氯 、 甲胺 以 氯仿 为溶剂， 生成 十九烷酸N-甲酰胺
  参考文献：
  名称：

  Infrared Study of the Amide Group Isolated in an Amorphous Hydrocarbon Matrix at Low Temperature: Aggregation and Rearrangement upon Annealing

  摘要：

  The amide group in a number of methyl N-alkyl and C-alkyl amides has been isolated at low temperature in a hydrocarbon environment. The infrared spectrum of the free amide group has been measured and its characteristic bands assigned. The amide bands for some of the hydrogen bonded n-mers have also been characterized: The isolation was achieved by the condensation of alkyl amide vapor onto the surface of a window at 8 K. Dilution with n-alkane vapor during the deposition was employed to increase the degree of isolation. The as-deposited films at 8 K were completely amorphous. A series of major structural changes occurred while the as-deposited films were annealed. These were monitored by infrared spectroscopy. With increasing temperature, the relative concentrations of the various n-mer species change to favor the higher n-mers. In addition, the hydrocarbon chains undergo conformational ordering, accompanied by a transformation of the amorphous solid to a crystalline solid. The triclinic subcell of the crystal changes to orthorhombic perpendicular with increasing temperature. The onset temperature and the chain-length dependence of the onset temperature for the various solid-solid transformations were compared to the corresponding values reported previously for similarly prepared amorphous films of the n-alkanes.

  DOI：

  10.1021/j100007a061

文献信息

• [EN] PROCESS FOR PRODUCING NITROGEN-CONTAINING COMPOUNDS<br/>[FR] PROCÉDÉ DE PRODUCTION DE COMPOSÉS AZOTÉS
  申请人：KAO CORP

  公开号：WO2009020244A1

  公开（公告）日：2009-02-12

  The present invention relates to a process for producing a tertiary amine in the presence of a catalyst containing copper and at least one element selected from the group consisting of elements belonging to Groups 2, 3, 7 and 12 of the Periodic Table (long form of the periodic table), said process including the steps of (a) reducing an amide compound in a hydrogen atmosphere; and (b) introducing a dialkyl amine containing a linear or branched alkyl group having 1 to 6 carbon atoms into a reaction product obtained in the step (a), and treating the reaction product with the dialkyl amine. The present invention provides a process for producing high-purity aliphatic tertiary amines containing a less amount of by-products by reducing aliphatic acid amides under moderate conditions using a chromium-free catalyst, as well as a process for producing amine derivatives such as amine oxide by using the aliphatic tertiary amines, with a good productivity in an economical manner.

  本发明涉及一种在含有铜和周期表长形式中属于2、3、7和12族元素之一的至少一种元素的催化剂存在下生产三级胺的方法，该方法包括以下步骤：(a) 在氢气氛中还原酰胺化合物；和(b) 将含有1至6个碳原子的线性或支链烷基基团的二烷基胺引入在步骤(a)中获得的反应产物中，并用二烷基胺处理反应产物。本发明提供了一种在中等条件下使用无铬催化剂还原脂肪酸酰胺从而生产含有较少副产物的高纯度脂肪族三级胺的方法，以及一种通过使用脂肪族三级胺生产胺氧化物等胺衍生物的方法，具有良好的经济生产能力。
• Process for preparing phthaloyl chloride
  申请人：Job Andreas

  公开号：US20050277788A1

  公开（公告）日：2005-12-15

  The invention relates to a novel process for preparing phthaloyl chloride (benzene-1,2-dicarbonyl chloride) by reacting phthalic anhydride with phosgene in the presence of a specific N,N-disubstituted formamide as a catalyst.

  本发明涉及一种新的制备邻苯二甲酰氯（苯1,2-二羧酸氯）的方法，其通过在特定的N，N-二取代甲酰胺催化剂存在下，将邻苯二甲酸酐与光气反应而得到。
• Method of calibrating ligand specificity
  申请人：Tanaka Akito

  公开号：US20070122913A1

  公开（公告）日：2007-05-31

  In a method comprising comparing a solid phase carrier extract 1 obtained by pre-treating a sample with a ligand-immobilized solid phase carrier and a solid phase carrier extract 2 obtained by treating the pretreated sample again with a ligand-immobilized solid phase carrier in terms of the proteins contained therein, and identifying a protein whose content is remarkably decreased in the extract 2 compared to the extract 1, 1) the problem of the solubility of subject ligand, 2) the problem of the non-specific protein-denaturing effect of the subject ligand added, and the like, which have been problematic in antagonism experiments in target search using an affinity resin, have been solved.

  在一种方法中，通过比较使用配体固定化固相载体预处理样品得到的固相载体提取物1和再次使用配体固定化固相载体处理预处理样品得到的固相载体提取物2中蛋白质的含量，并确定与提取物1相比提取物2中蛋白质含量明显减少的蛋白质。这种方法解决了在使用亲和树脂进行目标搜索的拮抗实验中存在的配体溶解度问题、添加的配体对非特异性蛋白质变性的影响等问题。
• METHOD OF CALIBRATING LIGAND SPECIFICITY
  申请人：Tanaka Akito

  公开号：US20090305435A1

  公开（公告）日：2009-12-10

  A method to determine specificity of ligand binding includes comparing a solid phase carrier first extract obtained by pre-treating a sample with a ligand-immobilized solid phase carrier and a solid phase carrier second extract obtained by treating the pretreated sample again with a ligand-immobilized solid phase carrier in terms of the proteins contained therein, and identifying a protein whose content is remarkably decreased in the second extract compared to the first extract, in order to solve 1 ) the problem of the solubility of subject ligand, 2 ) the problem of the non-specific protein-denaturing effect of the subject ligand added, and the like, in antagonism experiments in target search using an affinity resin.

  一种确定配体结合特异性的方法，包括比较通过用配体固定的固相载体预处理样品得到的固相载体第一提取物和再次用配体固定的固相载体处理预处理样品得到的固相载体第二提取物，其蛋白质含量，识别在第二提取物中与第一提取物相比明显减少的蛋白质，以解决在亲和树脂进行靶标搜索的拮抗实验中，目标配体的溶解度问题、添加的目标配体的非特异性蛋白变性效应等问题。
• N-alkylierte Formamide, Verfahren zu ihrer Herstellung und ihre Verwendung
  申请人：BAYER AG

  公开号：EP0050779A1

  公开（公告）日：1982-05-05

  N-alkylierte Formamide der Formel in der R' niederes Alkyl und R2 Alkyl mit mindestens 9 C-Atomen oder die Gruppe + A-NR1)̵nCHO bedeuten, wobei A geradkettiges oder verzweigtes Alkandiyl und n eine Zahl von 2 bis 6 bedeuten, werden durch Umsetzung der zugrunde liegenden sekundären Amine mit Ameisensäure bei erhöhter Temperatur. gegebenenfalls in Gegenwart eines inerten Lösungsmittels, erhalten. Sie sind nicht-toxische Beschleuniger für die Reaktion von Hydroxylgruppen in organischen Verbindungen mit anorganischen Säurehalogeniden oder Phosgen.

  式中的 N-烷基甲酰胺 其中 R' 是低级烷基，且 R2 是具有至少 9 个碳原子的烷基或基团 + A-NR1)̵nCHO，其中 A 是直链或支链烷二基，n 是 2 到 6 的数字、 它们是在高温下，必要时在惰性溶剂的存在下，通过底层仲胺与甲酸反应而得到的。 它们是有机化合物中羟基与无机酸卤化物或光气反应的无毒促进剂。