ethyl 2-amino-1'-(2-ethoxy-2-oxoethyl)-7,7-di methyl-2',5-dioxo-5,6,7,8-tetrahydrospiro [chromene-4,3'-indoline]-3-carboxylate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: ethyl 2-amino-1'-(2-ethoxy-2-oxoethyl)-7,7-di methyl-2',5-dioxo-5,6,7,8-tetrahydrospiro [chromene-4,3'-indoline]-3-carboxylate
• 英文别名: ethyl 2-amino-1'-(2-ethoxy-2-oxoethyl)-7,7-dimethyl-2',5-dioxo-5,6,7,8-tetrahydrospiro[chromene-4,3'-indoline]-3-carboxylate；Ethyl 2-amino-1'-(2-ethoxy-2-oxoethyl)-7,7-dimethyl-2',5-dioxo-1',2',5,6,7,8-hexahydrospiro[chromene-4,3'-indole]-3-carboxylate；ethyl 2-amino-1'-(2-ethoxy-2-oxoethyl)-7,7-dimethyl-2',5-dioxospiro[6,8-dihydrochromene-4,3'-indole]-3-carboxylate
• 化学式: C₂₅H₂₈N₂O₇
• 分子量: 468.507
• InChiKey: MTPAVHVEBCZJBM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  34
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  125
• 氢给体数：
  1
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  2,3-二氢-2,3-二氧代-1H-吲哚-1-乙酸乙酯 、 5,5-二甲基-1,3-环己二酮 、 氰乙酸乙酯 在 zirconium(IV) oxide 作用下， 以 水 为溶剂， 以95%的产率得到ethyl 2-amino-1'-(2-ethoxy-2-oxoethyl)-7,7-di methyl-2',5-dioxo-5,6,7,8-tetrahydrospiro [chromene-4,3'-indoline]-3-carboxylate
  参考文献：
  名称：

  通过球磨机中的一锅多组分反应，单斜氧化锆纳米颗粒催化区域选择性合成一些新型取代的螺吲哚：迈向绿色和可持续化学的一步

  摘要：

  摘要 建立了一种高效、绿色且原子经济的方案，用于从 m-ZrO2 NPs 催化靛红衍生物与氰乙酸乙酯和 1,3-二羰基化合物在球磨机中的多组分反应合成取代的螺吲哚。由于取代螺环吲哚的起始原料简单易得、操作方便、生物活性高，该策略可广泛应用于药物化学。m-ZrO2 Nps 催化剂的可回收性是所提出方法的另一个重点。图形概要

  DOI：

  10.1080/00397911.2017.1336244

文献信息

• Monoclinic zirconia nanoparticle-catalyzed regioselective synthesis of some novel substituted spirooxindoles through one-pot multicomponent reaction in a ball mill: A step toward green and sustainable chemistry
  作者：Shivam Bajpai、Sundaram Singh、Vandana Srivastava

  DOI：10.1080/00397911.2017.1336244

  日期：2017.8.18

  ABSTRACT A highly efficient, green as well as atom economical protocol for the synthesis of substituted spirooxindoles from m-ZrO2 NPs catalyzed multicomponent reaction of isatin derivatives with ethyl cyanoacetate and 1,3-dicarbonyl compounds in a ball mill has been established. Because of the simple and readily available starting materials, easy operation, and high bioactivity of substituted spirooxindoles

  摘要 建立了一种高效、绿色且原子经济的方案，用于从 m-ZrO2 NPs 催化靛红衍生物与氰乙酸乙酯和 1,3-二羰基化合物在球磨机中的多组分反应合成取代的螺吲哚。由于取代螺环吲哚的起始原料简单易得、操作方便、生物活性高，该策略可广泛应用于药物化学。m-ZrO2 Nps 催化剂的可回收性是所提出方法的另一个重点。图形概要
• Immobilization of 1,4-Diazabicyclo[2.2.2]Octane (DABCO) over Mesoporous Silica SBA-15: An Efficient Approach for the Synthesis of Functionalized Spirochromenes
  作者：Robabeh Baharfar、Razieh Azimi

  DOI：10.1080/00397911.2013.789527

  日期：2014.1.2

  Immobilized 1,4-diazabicyclo[2.2.2]octane (DABCO) over mesoporous silica SBA-15 has been found to be an efficient heterogeneous base catalyst for the synthesis of biologically active functionalized spirochromene derivatives via three-component reaction of isatins/acenaphthoquinone, activated methylene reagents, and 1,3-dicarbonyl compounds in aqueous media. This ecofriendly protocol offers several advantages such as a cost-effective procedure with excellent yield, short reaction time, simple workup, recovery and reusability of catalyst, good functional group tolerance, and broad scope of usable substrates. [Supplementary materials are available for this article. Go to the publisher's online edition of Synthetic Communications (R) for the following free supplemental resource(s): Full experimental and spectral details.]
• Environmentally friendly synthesis of Ag/SiO2 nanoparticles using Thymus kotschyanus extract and its application as a green catalyst for synthesis of spirooxindoles
  作者：Razieh Azimi、Zahra Lasemi

  DOI：10.1007/s11164-022-04667-z

  日期：2022.4

  of Ag/SiO2 nanoparticles is 25–60 nm. The Ag/SiO2 nanoparticles act as an environmentally friendly heterogeneous catalyst in the synthesis of spirooxindoles via the three-component condensation reaction of isatins, activated methylene reagents, and 1,3-dicarbonyl compounds in aqueous media, and the desired products were obtained with yields ranging from 90 to 98%. The catalyst can be recovered easily

  今天，基于合成程序的植物提取物已引起人们对传统方法（如物理和化学程序）合成纳米材料的考虑。纳米材料的绿色合成因其无害、经济、可行的方法等诸多优点而成为人们关注的领域，在生物医学、纳米技术和纳米光电子学等领域具有多种应用，并可作为各种有机转化的催化剂。在这项研究中，银纳米粒子通过 Ag +的原位还原沉积在纳米二氧化硅球的表面上。使用百里香地上部分的水提取物作为天然还原剂和封端剂的离子。紫外-可见 (UV-Vis) 光谱仪、傅里叶变换红外光谱 (FT-IR)、热重分析、扫描电子显微镜与能量色散 X 射线光谱 (SEM-EDS) 和 X 射线粉末衍射记录的结果支持 Ag/SiO 2纳米粒子的生物合成和表征。结果表明Ag/SiO 2纳米粒子的平均尺寸为25-60 nm。Ag/SiO 2纳米粒子作为环境友好型多相催化剂，通过靛红、活化亚甲基试剂和 1,3-二羰基化合物在水介质中的三组分缩合反应合成螺羟吲哚，得到所需产物，产率在