十二烷基苄基三甲基氯化铵 | 19014-05-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 十二烷基苄基三甲基氯化铵
• 中文别名: 十二烷苄基三甲基氯化铵；N,N,N-三甲基-4-十二烷基苯甲基氯化铵
• 英文名称: Dodecylbenzyltrimethylammonium chloride
• 英文别名: (4-dodecyl-benzyl)-trimethyl-ammonium; chloride；(4-Dodecyl-benzyl)-trimethyl-ammonium; Chlorid；Benzenemethanaminium, 4-dodecyl-N,N,N-trimethyl-, chloride；(4-dodecylphenyl)methyl-trimethylazanium;chloride
• CAS: 19014-05-2
• 化学式: C₂₂H₄₀N*Cl
• 分子量: 354.019
• InChiKey: YGKOYVNJPRSSRX-UHFFFAOYSA-M

物化性质

• 熔点：
  191 °C (decomp)

计算性质

• 辛醇/水分配系数(LogP)：
  3.36
• 重原子数：
  24
• 可旋转键数：
  13
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  正十二烷基苯 在 盐酸 、 zinc(II) chloride 作用下， 以 水 、 溶剂黄146 为溶剂， 生成 十二烷基苄基三甲基氯化铵
  参考文献：
  名称：

  Antimicrobial and surface-active properties of cationic surfactants based on chloroalkanes and alkylbenzenes

  摘要：

  DOI：

  10.1007/bf00779905
• 作为试剂：
  描述：

  二苯基硫氢硫化磷 、 4-溴丁腈 在 十二烷基苄基三甲基氯化铵 作用下， 生成 4-diphenylphosphinothioylsulfanylbutanenitrile
  参考文献：
  名称：

  使用二苯基亚膦二硫酸酯合成功能化不对称硫化物和二硫化物的方法

  摘要：

  制备了各种二苯基膦二硫代酸酯，并在温和的反应条件下与一些有机锂化合物反应，以良好的收率得到官能化的不对称硫化物和二硫化物。

  DOI：

  10.1246/cl.1979.723

文献信息

• [EN] CONJUGATES OF HETEROAROMATIC NITROGEN-COMPRISING COMPOUNDS<br/>[FR] CONJUGUÉS DE COMPOSÉS HÉTÉROAROMATIQUES CONTENANT DE L'AZOTE
  申请人：ASCENDIS PHARMA AS

  公开号：WO2020254606A1

  公开（公告）日：2020-12-24

  The present invention relates to conjugates of ΤΓ-electron-pair-donating heteroaromatic nitrogen-comprising drugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising said conjugates and the use of said conjugates as medicaments.

  本发明涉及ΤΓ-电子对供体杂芳氮含药物及其药用盐的结合物，包括所述结合物的药物组合物以及将所述结合物用作药物的用途。
• ANALOGS OF DEHYDROPHENYLAHISTINS AND THEIR THEAPEUTIC USE
  申请人：Palladino Michael A.

  公开号：US20080221122A1

  公开（公告）日：2008-09-11

  Compounds represented by the following structure (II) are disclosed: as are methods for making such compounds. Compositions and methods for treating various disease conditions including cancer and non-cancer diseases associated with vascular proliferation are also disclosed.

  由以下结构（II）表示的化合物已被披露：制备这种化合物的方法也已被披露。还披露了用于治疗各种疾病条件的组合物和方法，包括与血管增殖相关的癌症和非癌症疾病。
• [EN] THIOPHENE HYDROXAMIC ACID DERIVATIVES AND THEIR USE AS HDAC INHIBITORS<br/>[FR] DERIVES D'ACIDE HYDROXAMIQUE THIOPHENE ET LEUR UTILISATION COMME INHIBITEURS HDAC
  申请人：HOFFMANN LA ROCHE

  公开号：WO2005121120A1

  公开（公告）日：2005-12-22

  Objects of the present invention are the compounds of formula (I) their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above-mentioned compounds, medicaments containing them and their manufacture, as well as the use of the above-mentioned compounds in the control or prevention of illnesses such as cancer.

  本发明的对象是式（I）的化合物及其药学上可接受的盐、对映体形式、非对映异构体和消旋体，上述化合物的制备，含有它们的药物以及其制造，以及上述化合物在控制或预防癌症等疾病中的应用。
• Dehydrophenylahistins and analogs thereof and the synthesis of dehydrophenylahistins and analogs thereof
  申请人：Palladino A. Michael

  公开号：US20050197344A1

  公开（公告）日：2005-09-08

  Compounds represented by the following structure (I) are disclosed: as are methods for making such compounds, wherein said methods comprise reacting a diacyldiketopiperazine with a first aldehyde to produce an intermediate compound; and reacting the intermediate compound with a second aldehyde to produce the class of compounds with the generic structure, where the first aldehyde and the second aldehydes are selected from the group consisting of an oxazolecarboxaldeyhyde, imidazolecarboxaldehyde, a benzaldehyde, imidazolecarboxaldehyde derivatives, and benzaldehyde derivatives, thereby forming the above compound wherein R 1 , R 1 ′, R 1 ″, R 2 , R 3 , R 4 , R 5 , and R 6 , X 1 and X 2 , Y, Z, Z 1 , Z 2 , Z 3 , and Z 4 may each be separately defined in a manner consistent with the accompanying description. Compositions and methods for treating vascular proliferation are also disclosed.

  公开了以下结构（I）代表的化合物：制备这种化合物的方法也被公开，其中所述方法包括将二酰基二酮哌嗪与第一醛反应以产生中间化合物；然后将中间化合物与第二醛反应，以产生具有通用结构的化合物类，其中第一醛和第二醛选自氧唑羧醛，咪唑羧醛，苯甲醛，咪唑羧醛衍生物和苯甲醛衍生物组成的群体，从而形成上述化合物，其中R1、R1'、R1''、R2、R3、R4、R5和R6，X1和X2，Y，Z，Z1，Z2，Z3和Z4可以分别根据附带说明书中的描述进行定义。还公开了用于治疗血管增殖的组合物和方法。
• DEUTERATED DEHYDROPHENYLAHISTIN COMPOUNDS AND PREPARATION METHOD THEREOF AND USE THEREOF IN PREPARATION OF ANTI-TUMOR DRUGS
  申请人：MARINE BIOMEDICAL RESEARCH INSTITUTE OF QINGDAO CO., LTD.

  公开号：US20180140600A1

  公开（公告）日：2018-05-24

  Provided are a deuterium-substituted dehydrophenylahistin-like compound, preparation method thereof and use in a preparation of antitumor drugs. The deuterium-substituted dehydrophenylahistin-like compound has a structure of general formula (I), and a synthesis method thereof comprises: firstly conducting a condensation reaction of diacetyldiketopiperazine and an aldehyde intermediate a or a deuterated aldehyde compound b to form a heterocyclic compound c or a deuterium-containing heterocyclic compound d, which is then subjected to a condensation reaction with benzaldehyde and a deuterium-substituted benzaldehyde-like compound to form the deuterium-substituted dehydrophenylahistin-like compound. Also provided are a highly effective deuterated aldehyde intermediate with a high deuterium substitution rate and a deuterium-containing heterocycle intermediate, and a synthesis method thereof. An experiment shows that the deuterium-substituted dehyd-rophenylahistin-like compound provided by the present invention has an effect on tubulin depolymerization and can treat a refractory solid tumor or lymphoma. The present invention provides a method for researching and developing antitumor drugs of the related compound.

  提供了一种氘取代的类脱氢苯基组胺样化合物，其制备方法及在抗肿瘤药物制备中的用途。氘取代的类脱氢苯基组胺样化合物具有一般式(I)的结构，其合成方法包括：首先将双乙酰二酮环己二酮与醛中间体a或氘取代的醛化合物b进行缩合反应，形成杂环化合物c或含氘杂环化合物d，然后将其与苯甲醛和氘取代的苯甲醛样化合物进行缩合反应，形成氘取代的类脱氢苯基组胺样化合物。还提供了一种高效的氘取代的醛中间体，具有高氘取代率，以及含氘杂环中间体，以及其合成方法。实验证明，本发明提供的氘取代的类脱氢苯基组胺样化合物对微管去聚合具有作用，可用于治疗难治性实体肿瘤或淋巴瘤。本发明提供了一种研究和开发相关化合物抗肿瘤药物的方法。